DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and Sos

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	165/747 - (22%)
Similarity:	282/747 - (37%)	Gaps:	219/747 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 PTPT----ASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFS 277
            |:|.    |..||.|.|...|.|:..|..:|.|||.:|:|.| |.....:.||:..||:|||.|.
  Fly   612 PSPEIYKFAVPDSGDNIVLEERESAGVPMIKGATLCKLIERL-TYHIYADPTFVRTFLTTYRYFC 675

  Fly   278 TPKQVLSLLTQRYDALHEKHL--EELEQAQQNGQVMDPAYDPHASIHEQHKK------------T 328
            :|:|:|.||.:|:: :.:..|  ::...|...|.........|.:.|.:..|            .
  Fly   676 SPQQLLQLLVERFN-IPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFR 739

  Fly   329 LVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSEN 393
            :::.|..|:|....|:.:|.:               |..|:||.||.:
  Fly   740 VLNVLRHWVDHHFYDFEKDPM---------------LLEKLLNFLEHV----------------- 772

  Fly   394 NGHS---WLSAA------RSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQA 449
            ||.|   |:.:.      :::|                 ::.|...:...||.|
  Fly   773 NGKSMRKWVDSVLKIVQRKNEQ-----------------EKSNKKIVYAYGHDP----------- 809

  Fly   450 FRFPHVPVRH------------------FAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETV 496
                 .|:.|                  .|.|||.::.|::|.:.|.:.:|..|.::|.......
  Fly   810 -----PPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPN 869

  Fly   497 VATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYR 561
            :..|.:....:.|.:...:.:....:||...:.|.|::...:..|.||:.:.:|::|:.:.|:||
  Fly   870 LLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYR 934

  Fly   562 LSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGT 626
            |...::.|| ||...|.|            ..||:                ||.||:|....| .
  Fly   935 LRWTFQGLP-ERYRKFLE------------ECREL----------------SDDHLKKYQERL-R 969

  Fly   627 QTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADA 691
            ..:...:|:.|.:||::..:...|||.|...:||||.|:||..|::.:|:..|.  ..|.|..::
  Fly   970 SINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQN--QPYCLNEES 1032

  Fly   692 LFDHWFNSMPVF----DEREA---FELSCRLEP-----PPPAPRK----------------SVVS 728
            ....:|..:..|    |::.:   :..|.|:||     .|..|||                :..:
  Fly  1033 TIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTN 1097

  Fly   729 TNTSLTNTT--------ASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVH 785
            :::.|:|:|        |||||:.:......|:|::|...|.:.......|.|.:...|   ..|
  Fly  1098 SSSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMDAPTAAAANAGSGTLAGEQS---PQH 1159

  Fly   786 HQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHI--------- 841
            :.||..:.|...:...:..|      .||...|:::..|      ||..:..:||:
  Fly  1160 NPHAFSVFAPVIIPERNTSS------WSGTPQHTRTDQN------NGEVSVPAPHLPKKPGAHVW 1212

  Fly   842 ---NAQLVQ------------PSSGTPHSAPD 858
               |:.|..            |....|.|.||
  Fly  1213 ANNNSTLASASAMDVVFSPALPEHLPPQSLPD 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	37/145 (26%)
		RasGEF	454..719	CDD:214539	68/294 (23%)
		RalGDS_RA	858..946	CDD:176351	1/1 (100%)
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	44/187 (24%)
		RasGEF	825..1062	CDD:238087	63/268 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940