DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and Rapgef6

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_017452748.1	Gene:	Rapgef6 / 303141	RGDID:	1307645	Length:	1619	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	183/979 - (18%)
Similarity:	296/979 - (30%)	Gaps:	416/979 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 KVRYHRPTPTASNDSDDEI----SHLEWE---TVRVRFVKAATLARLVEALATDDGELESTFINV 268
            ::..|....|...:.:.||    .|.|.:   |.:...|..||..||:..|..:...::.|:|..
  Rat   378 RILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIED 442

  Fly   269 FLSTYRTF-STPKQV-LSLLTQ-RYDALHEK------------------------HLEE----LE 302
            ||.||||| .||..| :.||.. :.|:|.:|                        .|||    ||
  Rat   443 FLLTYRTFLETPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLE 507

  Fly   303 QAQQNG--QVMDPAYDPHASIHE--QHKKTLVSALHVWLDGFPE--------------------- 342
            ..:.||  ::::.|....|...:  ..|.:..|.||..|.|..|
  Rat   508 DTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLHFSLTGGSEKGFGVFVEVVEPGTKAADAGL 572

  Fly   343 -------DWHEDNLQQILAFATKRLKRSDLHI------------KVLNRLER------------- 375
                   :.:..|.:.|.......:.|::.|:            ::|:|.|:
  Rat   573 KRGDQIMEVNGQNFENITFAKALEILRNNTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAE 637

  Fly   376 -------------------------------------------------LIKQSLYGNGGGSG-- 389
                                                             ::...|:.:||.|.
  Rat   638 KKSNRHSIQDVPGDIEQVPQEKGNKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQ 702

  Fly   390 -----GSENNGHS--------WLSAARSQQMQ------QFMIPTHYGSSYDLTDQFNGMY----- 430
                 |:.:..||        .||::....:|      .|..|:..|..| :.||...::
  Rat   703 DDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSAVGFYY-IPDQVIRVFKADQQ 766

  Fly   431 --------------------------------------LSPMGHGPIYRGPTHF----------- 446
                                                  ::|.|.....|.|..|
  Rat   767 SCYIIISKDTTAKEVVCQAVQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNG 831

  Fly   447 ---------------------------LQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHT 484
                                       |...:...:.|   |.||:..|.:||:.:.|.:.:...
  Rat   832 RYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEV---ATQLSMRDFDLFRNIEPTEYIDDL 893

  Fly   485 WARRDSGGSETVVATINQF----NAVLFRVVSSILID--RLKPQERALNISRWIDIAQELRMLKN 543
            : :.||....|   .:.||    |...|.|.:.||.:  :||   |...|..:|.||...|..||
  Rat   894 F-KLDSKTGNT---HLKQFEDIVNQETFWVATEILSESNQLK---RMKIIKHFIKIALHCRECKN 951

  Fly   544 FSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDP 608
            |:|:.||||.||...:.||...||.||.:..:...:|.::.....|....|.:|
  Rat   952 FNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNIL----------- 1005

  Fly   609 GSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKR---KEFE 670
                |.:.:|..|           ||.......|:|.:|..|...:  :.|:||:|.|   ||..
  Rat  1006 ----SSQSMQPPI-----------IPLFPVVKKDMTFLHEGNDSKV--DGLVNFEKLRMIAKEIR 1053

  Fly   671 VLAQI----------------------KLLQGAANTYN-----------------LQADALFD-- 694
            .:.::                      .|.||:.|:..                 |.|..|::
  Rat  1054 HIIRMTSANMDPAMMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDA 1118

  Fly   695 -------HWFNSMPVFDEREAFEL--------------------SCRLEPPPPAPRKS------- 725
                   .:.:|:.:..|.|.|::                    |.|.....|.|.:|
  Rat  1119 QMARKVKQYLSSLDIDTEEEKFQMMSLQWEPAYGTLTKSLTEKKSARSSEMSPVPLRSAGHTAKV 1183

  Fly   726 -------------------------------VVSTNTSLTNTTASSTASIMGHRKTD-------S 752
                                           |:|||  |.......|..:.|.:.|:       |
  Rat  1184 HLHQPHRVSQVLQVPAVNLHPIRKKGQTRDHVLSTN--LPQKGLGPTEEVSGKKHTEDTISVASS 1246

  Fly   753 IHSN--SSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSGGRQSGK 815
            :||:  :|..:..:..|.|  :.||:.::|.   ...|:.:.|.||.|||.|:||.::.|:....
  Rat  1247 LHSSPPASPQSSPRKGCTL--TPSSKCDNLS---DSSHSEISSRSSIVSNGSVDSMSAAGQDERC 1306

  Fly   816 LTHS 819
            ..||
  Rat  1307 SAHS 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	44/268 (16%)
		RasGEF	454..719	CDD:214539	75/341 (22%)
		RalGDS_RA	858..946	CDD:176351
Rapgef6	XP_017452748.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900