DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and Ralgds

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_006233812.1	Gene:	Ralgds / 29622	RGDID:	3533	Length:	907	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	299/961 - (31%)
Similarity:	437/961 - (45%)	Gaps:	212/961 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 RRSRSASAKPRRNSS--------YHSYDDLDVSSAVLNAERKVVASLKYLCACTGATLRNLSKKT 177
            |||||.....|....        .||:..||                        ..|..|...|
  Rat    24 RRSRSVWDAVRLEVGVPDSCPVVLHSFTQLD------------------------PDLPRLESST 64

  Fly   178 KDLHAKNYTYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPTASNDS-----DDEISHLEWETV 237
            :::               |||.....|:::.|:||:.|   |.|:...     ::|.:...:||.
  Rat    65 QEI---------------GEELINGVIYSISLRKVQLH---PGATKGQRWLGCENESALNLYETC 111

  Fly   238 RVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELE 302
            :||.|||.||.:|||.|.......:.:::.|||.|||.|:|.:|||.||.:||.     ..:.|.
  Rat   112 KVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYG-----RCDALT 171

  Fly   303 QAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDN----LQQILAFATKRLKRS 363
            .:.:.|.:: |.........:|.|..:.|.|..|||.:.||:.:..    |:|::|:....:..|
  Rat   172 ASSRYGCIL-PYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS 235

  Fly   364 DL----HIKVLNRLERLIKQSLYGNGGGSGGSENNGHS---WLSAARSQQMQQ----FMIPTHYG 417
            ||    |: :|.:||.|....:          |....|   .||...:.|::.    .:.|:...
  Rat   236 DLERRAHL-LLAQLEDLEPSEV----------EPEALSPAPVLSLKPASQLEPAPALLLTPSRAV 289

  Fly   418 SSYDLTDQ------------FNGMYLSPMGHGPIYRGPT---------------HFLQA------ 449
            :|..:.:.            .....|.|....|:...||               |...|
  Rat   290 ASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPA 354

  Fly   450 ---------------FRFPHV---PVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE-- 494
                           ...||:   |....|||.|.||.||||:::|:.|||..|::||..|.|
  Rat   355 LEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHL 419

  Fly   495 --TVVATINQFNAVLFRVVSSILIDR-LKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNS 556
              |:.||:.|||.|...|:::.|.|: :|..:||..:..||::|:|.|:|||||||.||:|||.|
  Rat   420 APTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQS 484

  Fly   557 NSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAK------NPDPGSDHSDR 615
            |:|:||.|.||.:.:....||.:|:.|.|::||....||:|.:|||:|      ||        |
  Rat   485 NAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNP--------R 541

  Fly   616 HLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQG 680
            ..|:.....|  ...||:||||||||||.|:.||..||| ..:||||:|:||||||:|||||||.
  Rat   542 RTQRRQKETG--VIQGTVPYLGTFLTDLVMLDTAMKDYL-YGRLINFEKRRKEFEVIAQIKLLQS 603

  Fly   681 AANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKSVVSTNTSLTNTTASSTASI- 744
            |.|.|::..:..|..||.:|....|.|::.|||.||||         |.:.|.|..:..|||.:
  Rat   604 ACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPP---------SESASNTLRSKKSTAIVK 659

  Fly   745 -MGHRKTDSIHSNSSSGAGS----QFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVS--NLS 802
             ...|:..|...::||.|.|    |..|....|:....::|  .||    |..|:||.|.  |:|
  Rat   660 RWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDAL--SVH----SAGSSSSDVEEINMS 718

  Fly   803 LDSSNSGGRQSGKLTHSQSMG----NGLKSHGNGTTNGGSPHINAQLVQP-----------SSGT 852
            ....:..| |..|...|.|..    :|:.|..:.|::..:........:.           ||..
  Rat   719 FVPESPDG-QEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSL 782

  Fly   853 P---HSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGL-EDDPDRFTLA 913
            |   ....|..||||:.:.||..     :||||::.:.::.|.|||.||.|..| ||:|:.:.|.
  Rat   783 PLYNQQVGDCCIIRVSLDVDNGN-----MYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELL 842

  Fly   914 QVL-PDKELVMPKNANVYYAVNTNYNLNFILRPR---KEEGVAGSXSTAVP 960
            |:: .|.:|.:|:||||:||:|:..|.:|||:.|   |...|....|:.:|
  Rat   843 QIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLP 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	44/139 (32%)
		RasGEF	454..719	CDD:214539	129/278 (46%)
		RalGDS_RA	858..946	CDD:176351	38/89 (43%)
Ralgds	XP_006233812.1	RasGEFN	112..248	CDD:214571	46/142 (32%)
		DUF3275	205..344	CDD:288521	27/149 (18%)
		RasGEF	375..637	CDD:238087	124/272 (46%)
		RalGDS_RA	791..876	CDD:176351	38/89 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2941
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1959
OMA	1	1.010	-	-		QHG45636
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	1	1.000	-	-		FOG0003345
OrthoInspector	1	1.000	-	-		otm45262
orthoMCL	1	0.900	-	-		OOG6_106137
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1296
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880