DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and Rgl2

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_038954434.1	Gene:	Rgl2 / 294283	RGDID:	1302985	Length:	823	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	241/874 - (27%)
Similarity:	349/874 - (39%)	Gaps:	244/874 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LWGEEHEKNAIFTVYLKKVRYHRPT----PTASNDSDDEISHLEWETVRVRFVKAATLARLVEAL 254
            :|.|| |..|.|||..::.|...|:    |..|:                |.::|.||..||..|
  Rat    57 IWDEE-EDGATFTVTSRQYRPLDPSAPLPPPRSS----------------RRLRAGTLEALVRHL 104

  Fly   255 --ATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDP 317
              |...| .:.||....|:|:|.|::...:..|:..|.:||......|||:.
  Rat   105 LDARTSG-ADMTFTPALLATHRAFTSTPALFGLVADRLEALESHPPGELERT------------- 155

  Fly   318 HASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLY 382
                    ....:|.|..||...|||:..:...|                  |:|||..:.::.|
  Rat   156 --------TGVAISVLSTWLASHPEDFGSEVKGQ------------------LDRLESFLLRTGY 194

  Fly   383 ----GNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGP 443
                |..|||.....|..:.:........:...:|.  .|..|.||..  ::|:.
  Rat   195 AAREGVVGGSADLIRNLRARVDPRAPDLPKPLALPD--DSPADPTDVL--VFLAD---------- 245

  Fly   444 THFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATINQFN 504
                           |.|||||.:|.|||..|||.||||..|..||..|..    :|.||:.|||
  Rat   246 ---------------HLAEQLTLLDAELFLSLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFN 295

  Fly   505 AVLFRVVSSIL-------------IDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNS 556
            .|...||||:|             :..|:|.:||..:.:||.:|:|.|:|:||||:.|::|||.|
  Rat   296 KVAGAVVSSVLGATPTGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQS 360

  Fly   557 NSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNP-DPGSDHSDRHLQKL 620
            :.|:||...|....::.:.:|:.|..|.||::|....||:|.:|...:.| :|.|..:.|.
  Rat   361 SPIHRLRAAWGETTRDSLRIFSSLCQIFSEEDNYSQSRELLMQEVKLQPPVEPHSKKAPRS---- 421

  Fly   621 ILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRK------------------ 667
                |:: ..|.:|||||||.||.|:..|:.|.| ||..|||||:||
  Rat   422 ----GSR-GGGVVPYLGTFLKDLVMLDAASKDEL-ENGYINFDKRRKVRRMWGLRAGWWICVCVC 480

  Fly   668 ---------------------------EFEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFDE 705
                                       ||.||:::..||.....|:|:.:.....|...:....|
  Rat   481 PGDGVWVRVVKSGALSFGSCSLRPPSQEFAVLSELLRLQNECRGYDLRPNPDIQQWLQGLQPLTE 545

  Fly   706 REAFELSCRLEP----PPPAP---RKSVVSTN-----------TSLTN-------------TTAS 739
            .::..:||.:||    ..||.   |.::|.|.           |.|.:             |.|.
  Rat   546 AQSHRVSCEVEPSGTIDSPAARTLRPALVITQWTEVLGSVGGPTPLVSWDRPTVGGDEVPGTPAP 610

  Fly   740 STASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLD 804
            ....:..|.|..|:.|..|:         |.|| .|.|:..|..    |.|..::|...|.....
  Rat   611 LLTRLAQHMKWPSVSSLDSA---------LESS-PSLHSPADPG----HLSPPASSPRPSRGHRR 661

  Fly   805 SSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTPHSAPDFYIIRVTYETD 869
            |::.|...||......|...|.   |.|.:..||                  .|..||||..|..
  Rat   662 SASCGSPLSGGTGEGASRSAGC---GGGVSGPGS------------------SDCRIIRVQMELG 705

  Fly   870 NIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDD--PDRFTLAQVLP-DKELVMPKNANVYY 931
            .   ||.| ||||::.:.::.|.|| :.:||....|.  ...|.|.|:|| |:||.:|.:|||:|
  Rat   706 E---DGSV-YKSILVTSQDKAPSVI-SRVLKKNNRDSAVASEFELVQLLPGDRELTIPHSANVFY 765

  Fly   932 AVNTNYNLNFILRPRKEEGVAGSXSTAVP 960
            |:: ..:.:|:||.|:....|.| |.:.|
  Rat   766 AMD-GASHDFLLRQRRRPSAATSGSHSGP 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/133 (24%)
		RasGEF	454..719	CDD:214539	108/331 (33%)
		RalGDS_RA	858..946	CDD:176351	36/90 (40%)
Rgl2	XP_038954434.1	RasGEFN	90..212	CDD:214571	40/161 (25%)
		RasGEF	239..554	CDD:238087	106/351 (30%)
		RA_RGL2	694..779	CDD:340731	36/90 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8893
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880