Protein Alignment Rgl and Ralgdsl2

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_997712.1
• Gene: Ralgdsl2 / 294283
• RGDID: 1302985
• Length: 778
• Species: Rattus norvegicus
• Alignment Length: 829
• Identity: 241/829 - (29%)
• Similarity: 349/829 - (42%)
• Gaps: 199/829 - (24%)

  Fly   194 LWGEEHEKNAIFTVYLKKVRYHRPT----PTASNDSDDEISHLEWETVRVRFVKAATLARLVEAL 254
            :|.|| |..|.|||..::.|...|:    |..|:                |.::|.||..||..|
  Rat    57 IWDEE-EDGATFTVTSRQYRPLDPSAPLPPPRSS----------------RRLRAGTLEALVRHL 104

  Fly   255 --ATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDP 317
              |...| .:.||....|:|:|.|::...:..|:..|.:||......|||:.
  Rat   105 LDARTSG-ADMTFTPALLATHRAFTSTPALFGLVADRLEALESHPPGELERT------------- 155

  Fly   318 HASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLY 382
                    ....:|.|..||...|||:..:...|                  |:|||..:.::.|
  Rat   156 --------TGVAISVLSTWLASHPEDFGSEVKGQ------------------LDRLESFLLRTGY 194

  Fly   383 ----GNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGP 443
                |..|||.....|..:.:........:...:|.  .|..|.||..  ::|:.
  Rat   195 AAREGVVGGSADLIRNLRARVDPRAPDLPKPLALPD--DSPADPTDVL--VFLAD---------- 245

  Fly   444 THFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATINQFN 504
                           |.|||||.:|.|||..|||.||||..|..||..|..    :|.||:.|||
  Rat   246 ---------------HLAEQLTLLDAELFLSLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFN 295

  Fly   505 AVLFRVVSSIL-------------IDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNS 556
            .|...||||:|             :..|:|.:||..:.:||.:|:|.|:|:||||:.|::|||.|
  Rat   296 KVAGAVVSSVLGATPTGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQS 360

  Fly   557 NSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNP-DPGSDHSDRHLQKL 620
            :.|:||...|....::.:.:|:.|..|.||::|....||:|.:|...:.| :|.|..:.|.
  Rat   361 SPIHRLRAAWGETTRDSLRIFSSLCQIFSEEDNYSQSRELLMQEVKLQPPVEPHSKKAPRS---- 421

  Fly   621 ILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTY 685
                |:: ..|.:|||||||.||.|:..|:.|.| ||..|||||:||||.||:::..||.....|
  Rat   422 ----GSR-GGGVVPYLGTFLKDLVMLDAASKDEL-ENGYINFDKRRKEFAVLSELLRLQNECRGY 480

  Fly   686 NLQADALFDHWFNSMPVFDEREAFELSCRLEP----PPPAP---RKSVVSTN-----------TS 732
            :|:.:.....|...:....|.::..:||.:||    ..||.   |.::|.|.           |.
  Rat   481 DLRPNPDIQQWLQGLQPLTEAQSHRVSCEVEPSGTIDSPAARTLRPALVITQWTEVLGSVGGPTP 545

  Fly   733 LTN-------------TTASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDV 784
            |.:             |.|.....:..|.|..|:.|..|:         |.|| .|.|:..|..
  Rat   546 LVSWDRPTVGGDEVPGTPAPLLTRLAQHMKWPSVSSLDSA---------LESS-PSLHSPADPG- 599

  Fly   785 HHQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPS 849
               |.|..::|...|.....|::.|...||......|...|.   |.|.:..||
  Rat   600 ---HLSPPASSPRPSRGHRRSASCGSPLSGGTGEGASRSAGC---GGGVSGPGS----------- 647

  Fly   850 SGTPHSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDD--PDRFTL 912
                   .|..||||..|...   ||.| ||||::.:.::.|.|| :.:||....|.  ...|.|
  Rat   648 -------SDCRIIRVQMELGE---DGSV-YKSILVTSQDKAPSVI-SRVLKKNNRDSAVASEFEL 700

  Fly   913 AQVLP-DKELVMPKNANVYYAVNTNYNLNFILRPRKEEGVAGSXSTAVP 960
            .|:|| |:||.:|.:|||:||:: ..:.:|:||.|:....|.|.|.:.|
  Rat   701 VQLLPGDRELTIPHSANVFYAMD-GASHDFLLRQRRRPSAATSGSHSGP 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/133 (24%)
		RasGEF	454..719	CDD:214539	108/286 (38%)
		RA_RalGDS_like	858..946	CDD:340449	36/90 (40%)
Ralgdsl2	NP_997712.1	RasGEFN	90..212	CDD:214571	40/161 (25%)
		RasGEF	239..509	CDD:238087	106/306 (35%)
		RA_RGL2	649..734	CDD:340731	36/90 (40%)