DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and CG7369

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_649415.2	Gene:	CG7369 / 2768961	FlyBaseID:	FBgn0037188	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	153/760 - (20%)
Similarity:	252/760 - (33%)	Gaps:	262/760 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 HHHT---CPRQRKKSMTPVEPTHLCQKHQEAKQRRSRSASAKPRRNSSYHSYDDLDVSSAVLNAE 152
            |..|   .|.....|.|....||  :...:.|.:||         ||:.|:::.       |:|.
  Fly    31 HERTIVGVPGTGASSATTTSITH--KTLPDLKTQRS---------NSACHAHES-------LSAL 77

  Fly   153 RKVVASLKYLCACTGATLRNLSKKTKDLHAKNYTYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRP 217
            |::.                |.:|..:   |..:|.....|:.|:|..::  |.|| .:.|.|
  Fly    78 RRIA----------------LLEKPPE---KLLSYGAAQSRILGQEARED--FLVY-SEGRLH-- 118

  Fly   218 TPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQV 282
                |......|:|:                     :.|.:...:..||..||.:.|.|..|.::
  Fly   119 ----SGPLQSLIAHM---------------------VPTHEYYPDEGFIFAFLLSARLFVRPHEL 158

  Fly   283 LSLLTQRYDALHEKHLEELEQAQQNGQVMD-----PAYDPHASIH-------------------- 322
            |:.::|.::  |::     :.....|.|:|     |......||:
  Fly   159 LAQISQTWE--HQQ-----QDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAAASHSSE 216

  Fly   323 -----EQHKKTLVSALHV------WLDGFPEDWHEDNLQQ----------------------ILA 354
                 :|...|..||.|.      |::.||.|:.::.|.|                      ||.
  Fly   217 LEPRLQQRTNTQRSAQHCIRLLSEWIEIFPYDFRDERLMQQVRILARKCVYIDNSLGKQVSRILQ 281

  Fly   355 FATKRLKRSDLHIKVL--------------------------NRLERLIKQSLYGNGGGSGG--- 390
            ....||...:.:.:.|                          |..:..:..|.:.||...||
  Fly   282 LLVSRLTTLEQYEEFLQTISSEEAQSQQQQHHHHHGHHNHLHNAFQTFLGSSSHANGASGGGGSA 346

  Fly   391 -----SENNGHSWLSAARSQQMQQ-------FMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGP 443
                 |.::||: .||:.|..:..       |.|.....|...|..|...:.|..:.|    .||
  Fly   347 SGTSNSSSSGHT-SSASTSNSISTTPQPDDVFGIMDMCPSCAHLAHQLTAIELERLSH----IGP 406

  Fly   444 THFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGS-------ETVVATIN 501
            ..|:|||      .:.:.:|......|...    .:|.|      ..|||       ..:.:.:.
  Fly   407 EEFVQAF------AKDYQQQAKDGSREANN----SKCSG------GGGGSLNDMKKTRNLESYVQ 455

  Fly   502 QFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIW 566
            .||.:.:...|.| :...|.::|...|..||:.|:|...:.||:||.|||:.||...|.||.|.|
  Fly   456 WFNRLSYLTASEI-VKYPKKKQRVRIIEYWIETARECFNIGNFNSLMAIIAGLNLAPIGRLKKTW 519

  Fly   567 EVLPKERMEVFTELANICSEDNN-AWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSH 630
            ..:...:..|.....:..|..|: ..||:..:.|          |:.:....:::|
  Fly   520 AKVQSAKFSVLEHQMDPTSNFNSYRSTLKAAMWR----------SEGATEERERII--------- 565

  Fly   631 GTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDH 695
              ||:...|:.||..::....:.|..|. |||:|..:    ||: ::::             |:.
  Fly   566 --IPFFSLFVKDLYFLNEGCSNRLPNNH-INFEKCSQ----LAK-QVME-------------FNE 609

  Fly   696 W------FNSMP----------VFDEREAFELSCRLEPPPPAPRK 724
            |      |..:|          |.:|......|...|||.....|
  Fly   610 WKKVNCPFERLPNVIAYLQNSAVLNENTLSMASFECEPPENTEEK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	34/215 (16%)
		RasGEF	454..719	CDD:214539	62/288 (22%)
		RalGDS_RA	858..946	CDD:176351
CG7369	NP_649415.2	RasGEF_N	116..261	CDD:279012	33/178 (19%)
CG7369	NP_649415.2	RasGEF	388..649	CDD:214539	72/321 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940