Protein Alignment Rgl and Rapgefl1

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001074394.1
• Gene: Rapgefl1 / 268480
• MGIID: 3611446
• Length: 662
• Species: Mus musculus
• Alignment Length: 635
• Identity: 128/635 - (20%)
• Similarity: 226/635 - (35%)
• Gaps: 176/635 - (27%)

  Fly   166 TGATLRNLSKKTKDLHAKNYTYTKPTWRLWG----EEHEKNAIFTVYLKKVRYHRPTPTASNDSD 226
            :|..||:.|..:.|..:.......|.|...|    .||..|.:..      |....|...|:.||
Mouse   116 SGVPLRSPSSYSSDELSPGEPLASPPWAPLGAPERPEHLLNRVLE------RLAGGTTRDSSASD 174

  Fly   227 ---DEI--------------SHLEWETVRVRFV--------KAATLARLVEALATDDGEL--EST 264
               |:|              ..|....|:.|.|        |.|.||.|:..|.|..|.|  |..
Mouse   175 ILLDDIVLTHSLFLPTEKFLQELHQYFVQSRNVEGPEGLGRKQACLALLLHFLDTYQGLLQEEEG 239

  Fly   265 FINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEEL------EQAQQNGQVMDPAYDPHASIHE 323
            ..::....|......:.:...|  |.|.|....|.|.      |::|...:.:.|.:
Mouse   240 AGHIIKELYLLIMKDESLYQDL--REDTLRLHQLVETVELKIPEESQPPSKQVKPLF-------- 294

  Fly   324 QHKKTLVSAL--HVWLDGFPEDW-------H---------EDNLQQILAFATKRLKRSD------ 364
            :|.:.:.|.|  .|...|..|.:       |         ..::|.||...|::|:.|:
Mouse   295 RHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAERE 359

  Fly   365 ---LHIKVLNRLERLIKQSLYGNGGGSGGSEN--------NGHSWLSAARSQQMQQFMIPTHYGS 418
               :.:.|.:..|:::.|.          :|:        |.|.:   |.::...:.::|
Mouse   360 DALILVAVASSGEKVLLQP----------TEDCVFTTLGINSHLF---ACTRDSYEALVP----- 406

  Fly   419 SYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGH 483
               |.::   :.:|| |...|:|             |.....|..||....|||:.:...:.:.:
Mouse   407 ---LPEE---VQVSP-GDTEIHR-------------VEPEDVANHLTAFHWELFRCVHELEFVDY 451

  Fly   484 TW----ARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNF 544
            .:    .||::...|.:   :.:.:.|...|.:.:|:.. .|.:|...:.::|.||...:..::.
Mouse   452 VFHGERGRRETANLELL---LQRCSEVTHWVATEVLLCE-APGKRVQLLKKFIKIAAICKQNQDL 512

  Fly   545 SSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPG 609
            .|..|::..|::.::.||...||.||.:...:|.:...:.....|..:.|||:.:   .|.|
Mouse   513 LSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISK---MKPP--- 571

  Fly   610 SDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQ 674
                                  .||::...|.|||.:|..:...:  :.|:|.:|.....|.:..
Mouse   572 ----------------------LIPFVPLILKDLTFLHEGSKTLV--DGLVNIEKLHSVAEKVRT 612

  Fly   675 IK-------LLQGAANTYNLQADALFDHWFNSMPVFD-EREAFELSCRLE 716
            |:       .|...|:.::||..|    :.....|.| :...||||.:||
Mouse   613 IRKYRSRPLCLDMEASPHHLQTKA----YVRQFQVIDNQNHLFELSYKLE 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	33/166 (20%)
		RasGEF	454..719	CDD:214539	59/275 (21%)
		RalGDS_RA	858..946	CDD:176351
Rapgefl1	NP_001074394.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..149		8/32 (25%)
		RasGEF	420..658	CDD:214539	59/288 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900