DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and efc25

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_596123.1	Gene:	efc25 / 2540248	PomBaseID:	SPBC336.03	Length:	987	Species:	Schizosaccharomyces pombe

Alignment Length:	498	Identity:	115/498 - (23%)
Similarity:	201/498 - (40%)	Gaps:	129/498 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 VKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQ 306
            ||..||..||..| ..:..|...|.:.||.||:||:||:::.:||...:   ||
pombe   594 VKGGTLPALVHYL-VQNVHLNKDFRHSFLLTYKTFTTPQELFTLLVILF---HE----------- 643

  Fly   307 NGQVMDPAYDPHA-SIHEQ-----HKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDL 365
               :..|..|..| |..|:     .||.:.:.:::|:..:   :.||
pombe   644 ---LPPPGLDATAYSSWEKGDNFVTKKNVCTVMNLWVQKY---FFED------------------ 684

  Fly   366 HIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFN--- 427
             :|..|.|                        :|.:.....::..::|:.:..|..|::..|
pombe   685 -LKARNTL------------------------YLISEMRTFLRDHVVPSFHIGSVILSEIDNLWT 724

  Fly   428 ---------GMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGH 483
                     .:..|||         ..|:....:.:.| ..||.|:|.::.:..|::...:.:..
pombe   725 EEPPDSLTQRLLSSPM---------ATFISLNVYAYTP-EEFASQMTLLEFDYLKQIPSREWIFR 779

  Fly   484 TWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLK 548
            :|..|||  ...|...||..|...:.:::.|| ::...:.|...||.:|..|.:...|:|||:|.
pombe   780 SWVSRDS--RSAVRNYINFSNCFTYWIINCIL-EKKNTKARTAVISFFIQTAYKCLSLQNFSTLM 841

  Fly   549 AIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHS 613
            :|:|||||..||||...::::..|.:...:.|..|.....|..|.|.:|::   |:.|
pombe   842 SIVSALNSAPIYRLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRK---AELP------- 896

  Fly   614 DRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTEN-KLINFDKKRKEFEVLAQIKL 677
                              .:|:||..|:|||.|...|||.|..: .|::|:|:.:..:|:|.:..
pombe   897 ------------------CVPFLGVILSDLTFIDEGNPDVLDSSPHLLSFNKRHRLADVVADVCR 943

  Fly   678 LQGAANTYNLQADALFDHWFNSMPVF---DEREAFELSCRLEP 717
            .|  :::|.:|::.....:......|   |....|:.|..|||
pombe   944 FQ--SSSYEMQSNTDLQSYILHRCRFVNQDLSYLFDKSLSLEP 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	32/137 (23%)
		RasGEF	454..719	CDD:214539	72/268 (27%)
		RalGDS_RA	858..946	CDD:176351
efc25	NP_596123.1	RasGEF_N	593..700	CDD:279012	35/169 (21%)
efc25	NP_596123.1	RasGEF	755..932	CDD:279011	59/207 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010