DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and Rapgef3

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_036015267.1	Gene:	Rapgef3 / 223864	MGIID:	2441741	Length:	963	Species:	Mus musculus

Alignment Length:	739	Identity:	161/739 - (21%)
Similarity:	259/739 - (35%)	Gaps:	266/739 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 SSYHSYDDLDVSSAVLNAERKVVASLK-YLCACTGATLRNLSKKTKDLHAKNYTYTKPTWRLWGE 197
            ::.|..||....:.|.:|.|.....|: ..|.......::.::..||:.||       |.||  |
Mouse   336 TTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAK-------TMRL--E 391

  Fly   198 EHEKNAIFTVYLKKVRY-----HRPTP-----TASNDSDDEISHLEWETVRVRFVKAATLARLVE 252
            ||.|   ..:.|::...     ..|||     |..:.:.::|..|                 |:|
Mouse   392 EHGK---VVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILEL-----------------LLE 436

  Fly   253 ALATDDG--ELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAY 315
            |:..|..  :...||::.||.|:..|....|:.:.|      ||..|:|             ||
Mouse   437 AMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLFTAL------LHHFHVE-------------PA- 481

  Fly   316 DPHASIHEQH-------KKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRL-KRSDLHIKVLNR 372
            ||.....::|       ::.::..:..|:..:....|.|.:      ||..| |.||| :....|
Mouse   482 DPAGGSEQEHSTYICNKRQQILRLVGRWVALYSPMLHSDPV------ATSFLQKLSDL-VSRDAR 539

  Fly   373 LERLIKQSL--------YGNGGGSGGSE---NNGHSWLSAARSQQMQQFMIPTHYGS-------S 419
            |..|:::..        ..||.|:...:   .|...||      ..|:..:|:..|:       .
Mouse   540 LSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWL------PNQEEPLPSSAGAIRVGDKVP 598

  Fly   420 YDL---------------------------TDQF-NGMYL-------SPMGHGPIYRG------- 442
            ||:                           .|.: .|..|       ..:|..|..||
Mouse   599 YDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGL 663

  Fly   443 ----------PTHFLQAFRFPH----------------VPVRHFAEQLTRMDTELFKRL------ 475
                      ..|.|.    ||                |..:..|.|||..|..||.|:
Mouse   664 NERLFVVDPQEVHELT----PHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQEV 724

  Fly   476 -IPHQCLG--HTWARRDSGGSETVVATIN------QFNAVLFRVVSSILIDRLKPQERALNISRW 531
             :.|..||  |.   ||       |.|.|      :||.:.:.|.:.:.:..: |..||..:.::
Mouse   725 ELIHYVLGPQHL---RD-------VTTANLERFMRRFNELQYWVATELCLCPV-PGSRAQLLRKF 778

  Fly   532 IDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREV 596
            |.:|..|:..||.:|..|::..|::::|.||:..||.||.:..::::.|..:.
Mouse   779 IKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLL------------ 831

  Fly   597 LKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLIN 661
                      ||..:|   .:.:|.|   |:.|...||::...|.|:|.||..| ..|.|| |||
Mouse   832 ----------DPSWNH---RVYRLAL---TKLSPPVIPFMPLLLKDVTFIHEGN-HTLVEN-LIN 878

  Fly   662 FDKKRKEFEVLAQ-IKLL-------------------------QGA----ANTYNLQADALFDHW 696
            |:|.|    ::|: :::|                         ||:    .:..:|...:....|
Mouse   879 FEKMR----MMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPASTW 939

  Fly   697 --FNSMPVFD-EREAFELSCRLEP 717
              ...:.|.| :||...||..|||
Mouse   940 AYVQQLKVIDNQRELSRLSRELEP 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	34/141 (24%)
		RasGEF	454..719	CDD:214539	80/328 (24%)
		RalGDS_RA	858..946	CDD:176351
Rapgef3	XP_036015267.1	DEP_Epac	131..257	CDD:239884
		CAP_ED	281..390	CDD:237999	13/60 (22%)
		RasGEF_N	421..530	CDD:395493	30/151 (20%)
		RasGEF	695..963	CDD:214539	77/312 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810