DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and RASGEF1A

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001269791.1	Gene:	RASGEF1A / 221002	HGNCID:	24246	Length:	489	Species:	Homo sapiens

Alignment Length:	521	Identity:	113/521 - (21%)
Similarity:	197/521 - (37%)	Gaps:	117/521 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 AATLARLVEALA-TDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQN 307
            :.:|..|:|.|. |.|...:.|:|..||.:.|.|..|..:|:    |...:..:..::||...:.
Human    55 SGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLA----RVGQICVEQKQQLEAGPEK 115

  Fly   308 GQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNR 372
            .::            :.....:|..|..|.:.||.|:.::.....|...|.|:.:.|.....:.:
Human   116 AKL------------KSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKK 168

  Fly   373 LERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSP--MG 435
            ....:.|||.                ||.|...|:|            :|.::     |.|  :.
Human   169 AIAQMTQSLL----------------LSLAARSQLQ------------ELREK-----LRPPAVD 200

  Fly   436 HGPIYR-----GPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIP---------------HQC 480
            .|||.:     .....|.....|.|    .|:|||.::.:....:.|               |:|
Human   201 KGPILKTKPPAAQKDILGVCCDPLV----LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRC 261

  Fly   481 LGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFS 545
            .|      |...:.::.|..|.||. |..:|::.:...:|.:.|...:..:||:|:|...:.||:
Human   262 RG------DLTKTYSLEAYDNWFNC-LSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFN 319

  Fly   546 SLKAIISALNSNSIYRLSKIWEVLPKERMEVFTE----LANICSEDNNAWTLREVLKREGTAKNP 606
            |:.||||.:|.:.:.||.|.|..:...:.:|...    .:|.|   |....|:...:|...|
Human   320 SMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFC---NYRTALQGATQRSQMA--- 378

  Fly   607 DPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEV 671
                 :|.|  :|::           ||....|:.|:..:|..:.::| .|..|||   :|.:|:
Human   379 -----NSSR--EKIV-----------IPVFNLFVKDIYFLHKIHTNHL-PNGHINF---KKFWEI 421

  Fly   672 LAQI-KLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKSVVST-NTSLT 734
            ..|| :.:.........:.|.....:..:.|::.|...|..|...|.|.....|....| .|:|.
Human   422 SRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLL 486

  Fly   735 N 735
            |
Human   487 N 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	27/132 (20%)
		RasGEF	454..719	CDD:214539	64/284 (23%)
		RalGDS_RA	858..946	CDD:176351
RASGEF1A	NP_001269791.1	REM	57..184	CDD:100121	33/158 (21%)
RASGEF1A	NP_001269791.1	RasGEF	222..470	CDD:214539	65/286 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910