Protein Alignment Rgl and Rapgef5

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001360918.1
• Gene: Rapgef5 / 217944
• MGIID: 2444365
• Length: 879
• Species: Mus musculus
• Alignment Length: 608
• Identity: 122/608 - (20%)
• Similarity: 218/608 - (35%)
• Gaps: 176/608 - (28%)

  Fly   209 LKKVRYHRPTPTASNDSDDEISHLEWETVRVRF-VKAATLARLVEALATD-------DGELESTF 265
            ||||....|.||:.:..:|           .|: |.:.|..:::|.|..|       ..|.| |.
Mouse   347 LKKVASCGPAPTSGSAEND-----------ARYVVVSGTPEKILEHLLNDLHLAEVQHKETE-TL 399

  Fly   266 INVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLV 330
            ::.||.||..|.|...:...|.:.|.|      ::.:..::|..|  |.          .|:.::
Mouse   400 LDDFLLTYTVFMTTDDLCQALLRHYSA------KKYQGEEENSDV--PC----------RKRKVL 446

  Fly   331 SALHVWLDGFPEDW-HEDNLQQILAFATKRLKRSDLH-----IKVLNRLERL------------- 376
            ..:..|:..: :|| |||...::......|....|::     .|.|...:::
Mouse   447 HLVSQWISLY-KDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGVYRRHTVDEYS 510

  Fly   377 -------------IKQSLYGNGGGSGGSEN-------NGHSWLSA-------------------A 402
                         :|::...:.|....:|.       ..||::|.                   .
Mouse   511 PQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYITEHSYISVKAKVSSTAQEILKVVAEKLQ 575

  Fly   403 RSQQMQQFMIPTHYGSSY------------------------DLTDQFNGMYLSPMGHGPIYRGP 443
            |:::....:..|..|..:                        ||.|..|          |:....
Mouse   576 RAEEDLALVAITFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLN----------PLAENE 630

  Fly   444 THFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQ-FNAVL 507
            ....::.|...:.....|.:|...|..||..:...:.:..|::|:.:|.:...::.:.| .|.|.
Mouse   631 ESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGNGENTVNLSLLLQRCNEVQ 695

  Fly   508 FRVVSSILI-DRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPK 571
            ..|.:.||: .:|  .:|...:.::|.||...:..:|.:|..||:..||:.|:.|||:.||.:|.
Mouse   696 LWVATEILLCSQL--GKRVQLVKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPG 758

  Fly   572 ERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYL 636
            :..::|:||.::.....|....|:..|:....|                            ||::
Mouse   759 KFKKLFSELESLTDPSLNHKAYRDAFKKMKPPK----------------------------IPFM 795

  Fly   637 GTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADAL------FDH 695
            ...|.|:|.||..|..:|  :.|:||:|    ..::|..........|....:|..      ...
Mouse   796 PLLLKDVTFIHEGNKTFL--DNLVNFEK----LHMIADTVRTLRHCRTNQFGSDVSPKEQQELKS 854

  Fly   696 WFNSMPVFDEREA-FELSCRLEP 717
            :.|.:.|.|.::| ||||.||||
Mouse   855 YVNHLYVIDSQQALFELSHRLEP 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	30/170 (18%)
		RasGEF	454..719	CDD:214539	67/273 (25%)
		RalGDS_RA	858..946	CDD:176351
Rapgef5	NP_001360918.1	DEP_Epac	98..221	CDD:239884
		RasGEFN	367..498	CDD:214571	32/150 (21%)
		RasGEF	639..878	CDD:214539	67/275 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810