DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rgl and Rgl2

DIOPT Version :9

Sequence 1:NP_001261814.1 Gene:Rgl / 44115 FlyBaseID:FBgn0026376 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_033085.2 Gene:Rgl2 / 19732 MGIID:107483 Length:778 Species:Mus musculus


Alignment Length:838 Identity:243/838 - (28%)
Similarity:346/838 - (41%) Gaps:205/838 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 LWGEEHEKNAIFTVYLKKVR-----YHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEA 253
            :|.|| |..|.|||..::.|     ...|.|.:|                 |.::|.||..||..
Mouse    57 VWDEE-EDGATFTVTSRQYRPLDPLAPLPPPRSS-----------------RRLRAGTLEALVRH 103

  Fly   254 L--ATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYD 316
            |  |...| .:..|....|:|:|.|::...:..|:..|.:||......|||:.            
Mouse   104 LLDARTAG-ADMMFTPALLATHRAFTSTPALFGLVADRLEALESHPPGELERT------------ 155

  Fly   317 PHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSL 381
                     ....:|.|..||...|||:..:...|                  |:|||..:.::.
Mouse   156 ---------TGVAISVLSTWLASHPEDFGSEVKGQ------------------LDRLESFLLRTG 193

  Fly   382 Y----GNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRG 442
            |    |..|||.....|..:.:........:...:|                     |..|  ..
Mouse   194 YAAREGVVGGSADLIRNLRARVDPRAPDLPKPLALP---------------------GDSP--AD 235

  Fly   443 PTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATINQF 503
            ||..|...      ..|.|||||.:|.|||..|||.||||..|..||..|..    :|.||:.||
Mouse   236 PTDVLVFL------ADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQF 294

  Fly   504 NAVLFRVVSSIL-------------IDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALN 555
            |.|...||||:|             :..|:|.:||..:.:||.:|:|.|:|:||||:.|::|||.
Mouse   295 NKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQ 359

  Fly   556 SNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKL 620
            |:.|:||...|....::.:.||:.|..|.||::|....||:|.:|  .|...|...||     |.
Mouse   360 SSPIHRLRAAWGETTRDSLRVFSSLCQIFSEEDNYSQSRELLMQE--VKPQPPVEPHS-----KK 417

  Fly   621 ILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTY 685
            ....|.: ..|.:|||||||.||.|:..|:.|.| ||..|||||:||||.:|:::..||.....|
Mouse   418 APRSGFR-GGGVVPYLGTFLKDLVMLDAASKDEL-ENGYINFDKRRKEFAILSELLRLQKECRGY 480

  Fly   686 NLQADALFDHWFNSMPVFDEREAFELSCRLEPP-----PPA--PRKSVVSTN-----------TS 732
            :|:.::....|...:....|.::..:||.:|||     |.|  ||.::|.|.           |.
Mouse   481 DLRPNSDIQQWLQGLQPLTEAQSHRVSCEVEPPGTSDSPAARTPRPTLVITQWTEVLGSVGGPTP 545

  Fly   733 LTN-------------TTASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDV 784
            |.:             |.|.....:..|.|..|:.|..|:         |.|| .|.|:..|.. 
Mouse   546 LVSWDRPSVGGDEVPGTPAPLLTRLAQHMKWPSVSSLDSA---------LESS-PSLHSPADPG- 599

  Fly   785 HHQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPS 849
               |.|..::|...|.....|::.|...||......|...|.   |.|.:..||           
Mouse   600 ---HLSPPASSPRPSRGHRRSASCGSPLSGNTGEGTSRSAGC---GGGVSGPGS----------- 647

  Fly   850 SGTPHSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDD--PDRFTL 912
                   .|..||||..|...   ||.| ||||::.:.::.|.|| :.:||....|.  ...|.|
Mouse   648 -------SDCRIIRVQMELGE---DGSV-YKSILVTSQDKAPSVI-SRVLKKNNRDSAVASEFEL 700

  Fly   913 AQVLP-DKELVMPKNANVYYAVNTNYNLNFILRPRKEEGVA------GSXSTAVPLSQ 963
            .|:|| |:||.:|.:|||:||:: ..:.:|:||.|:....|      |. ::..|.|:
Mouse   701 VQLLPGDRELTIPHSANVFYAMD-GASHDFLLRQRRRPSAATPGSHSGPSASGTPPSE 757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RglNP_001261814.1 REM 246..378 CDD:100121 31/133 (23%)
RasGEF 454..719 CDD:214539 110/286 (38%)
RalGDS_RA 858..946 CDD:176351 36/90 (40%)
Rgl2NP_033085.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 0/1 (0%)
RasGEFN 90..212 CDD:214571 39/161 (24%)
RasGEF 239..513 CDD:214539 109/288 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..524 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..564 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 581..647 20/82 (24%)
RalGDS_RA 649..734 CDD:176351 36/90 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..769 4/23 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 74 1.000 Domainoid score I9083
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D116220at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3106
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
87.910

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