Protein Alignment Rgl and Rgl1

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001333046.1
• Gene: Rgl1 / 19731
• MGIID: 107484
• Length: 803
• Species: Mus musculus
• Alignment Length: 822
• Identity: 295/822 - (35%)
• Similarity: 425/822 - (51%)
• Gaps: 141/822 - (17%)

  Fly   195 WGEEHEKNAIFTVYLKKVRYHRPTPTASND-------SDDEI--SHL--EWETVRVRFVKAATLA 248
            ||||.|:.|::.|.||:|:..:    |:|.       ..|::  .|.  ::||.::|.:||.||.
Mouse    50 WGEEVEEGAVYHVTLKRVQIQQ----AANKGARWLGVEGDQLPPGHTVSQYETCKIRTIKAGTLE 110

  Fly   249 RLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDP 313
            :|||.|.|..|:.:.|:|::||||||.|::.|:||.||..||..|...:.|:      :|....|
Mouse   111 KLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTGPNCED------DGSQSSP 169

  Fly   314 AYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDN----LQQILAFATKRLKRSDLHIKVLNRLE 374
              :..|.|    :..:.|.|..|||...||:.|..    ||::|.:..:.:..||...:..|.||
Mouse   170 --ESKAVI----RNAIASILRAWLDQCAEDFREPPHFPCLQKLLEYLKQMMPGSDPERRAQNLLE 228

  Fly   375 RLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPI 439
            :..||.:..:.|....|.      .|....::::.       |.|.:.|:....:
Mouse   229 QFQKQDVDSDNGLLNTSS------FSLEEEEELES-------GGSAEFTNFSEDL---------- 270

  Fly   440 YRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATI 500
                                .|||||.||.:|||:::||.|||..|::||...::    |:.|||
Mouse   271 --------------------VAEQLTYMDAQLFKKVVPHHCLGCIWSQRDKKENKHLAPTIRATI 315

  Fly   501 NQFNAVLFRVVSSILIDR-LKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSK 564
            :|||.:...|||::|..: ||.|:||..|.:||:||.|.|:|||||||:||:|||.|||||||.|
Mouse   316 SQFNTLTKCVVSTVLGSKELKTQQRARVIEKWINIAHECRILKNFSSLRAIVSALQSNSIYRLKK 380

  Fly   565 IWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAK--NPDPG-SDHSDRHLQKLILNLGT 626
            .|..:||:||.:|.||::|.|:.||..|.||:|.:|||:|  |.|.. .::..|..::|.|....
Mouse   381 AWAAVPKDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDM 445

  Fly   627 QTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADA 691
            ....||:||||||||||||:.||..||: |..||||:|:|:||||:|||||||.|.|:|.:..|.
Mouse   446 GVMQGTVPYLGTFLTDLTMLDTALQDYI-EGGLINFEKRRREFEVIAQIKLLQSACNSYCMGPDQ 509

  Fly   692 LFDHWFNSMPVFDEREAFELSCRLE------PPPPAPRKSVVSTNTSL------------TNTTA 738
            .|..||....:..|.|::.|||.:|      ...|.||||:|...:.|            |....
Mouse   510 KFIQWFQRQQLLSEEESYALSCEIEAAADANTTSPKPRKSMVKRLSLLFLGSDIIPGSTPTKEQP 574

  Fly   739 SSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQ-HASLMSASSSVSNL- 801
            .|.||.......||:..:|         ||.|.|.:........|...: ...|..:|||.|::
Mouse   575 KSAASGSSGESMDSVSVSS---------CESNHSEAEEGPVTPMDTPDEPQKKLSESSSSCSSIH 630

  Fly   802 SLDSSNSGGRQSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSSGTPHSAPDFY------ 860
            |:|:::||         ..|:.|.|.|   ..|...:|.|:.:.|..:|.|....|..|
Mouse   631 SMDTNSSG---------MSSLINPLSS---PPTCNNNPKIHKRSVSVTSITSTVLPPVYNQQNED 683

  Fly   861 --IIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDDP-DRFTLAQVL-PDKEL 921
              |||::.|.:|..     :||||||.:.::||.||:.||.|..||.|| :.:.|.||: .||||
Mouse   684 TCIIRISVEDNNGN-----MYKSIMLTSQDKTPAVIQRAMSKHNLESDPAEEYELVQVISEDKEL 743

  Fly   922 VMPKNANVYYAVNTNYNLNFILRPRK--EEGVAGSXSTAVPL 961
            |:|.:|||:||:|:..|.:||||.:.  ||.|... .|::.|
Mouse   744 VIPDSANVFYAMNSQVNFDFILRKKNSVEEQVKLRSRTSLTL 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	46/135 (34%)
		RasGEF	454..719	CDD:214539	135/278 (49%)
		RA_RalGDS_like	858..946	CDD:340449	43/97 (44%)
Rgl1	NP_001333046.1	RasGEFN	100..231	CDD:214571	49/142 (35%)
		RasGEF	263..532	CDD:238087	134/299 (45%)
		RA_RGL	682..768	CDD:340730	42/90 (47%)