DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rgl and Rasgrf1

DIOPT Version :9

Sequence 1:NP_001261814.1 Gene:Rgl / 44115 FlyBaseID:FBgn0026376 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_035375.1 Gene:Rasgrf1 / 19417 MGIID:99694 Length:1262 Species:Mus musculus


Alignment Length:713 Identity:147/713 - (20%)
Similarity:233/713 - (32%) Gaps:244/713 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   200 EKNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRF-----------VKAATLARLVEA 253
            |:|:..||         |....|:.|      |..:.|.:||           ::.|::.||:|.
Mouse   601 EENSKVTV---------PQMIKSDAS------LYCDDVDIRFSKTMNSCKVLQIRYASVERLLER 650

  Fly   254 LATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRY----DALHEKHLEELEQAQQNGQVM--- 311
            | ||...|...|:|.||.:||.|:....||..|...|    .|:..:.||.|..:..|.:::   
Mouse   651 L-TDLRFLSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLELLFSSSHNAKLLYGD 714

  Fly   312 ----------------------DP--------------------------AYDPHASIHEQ---- 324
                                  .|                          :.|.:|:||..    
Mouse   715 APKSPRASRKFSSPPPLAIGTSSPSRRRKLSLNIPIITGGKALELASLGCSSDSYANIHSPISPF 779

  Fly   325 HKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLH----------------------- 366
            .|.||.:.........|:...|.::...:......|..|..|                       
Mouse   780 GKTTLDTGKLCMASSLPKTPEEIDVPATIPEKPGELSASRKHSSDVLKEESEDDQNHSDEDNTEV 844

  Fly   367 --IK-------VLNRLERLIKQSLYGNG----------------------------GGSGGSENN 394
              :|       .|||.........|.||                            |.:.|..|.
Mouse   845 SPVKSPPTPKSFLNRTITEFPFFNYNNGILMTTCRDLVDNNRSTLSATSAFAIATAGANEGPSNK 909

  Fly   395 --------GHSWLSAARSQQMQQFMI---------------PTHYGSSYDLTDQFNG---MYLSP 433
                    .::..|:.:....::|:|               .|.:...:|..|....   .:|..
Mouse   910 EVFRRMSLANTGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQDFDTDDTLKYRVICFLEE 974

  Fly   434 MGHGP------------IYRG------------------PTHFLQAFRFPHVPVRHFAEQLTRMD 468
            :.|.|            |.|.                  .|..::...|.:.|....|||||.:|
Mouse   975 VMHDPDLLTQERKAAANIIRTLTLEETTEQHSMLEEVILMTEGVKTEPFENHPALEIAEQLTLLD 1039

  Fly   469 TELFKRLIPHQCLGHTWARRDS-GGSETVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWI 532
            ..:||.:...:..|..|.:.:. ..:..::.|...||.| ...::|.:|.......||..|.:|:
Mouse  1040 HLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHV-SNFIASEIIRNEDISARASAIEKWV 1103

  Fly   533 DIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVL 597
            .:|...|.|.|::::..|.|::|.::|:||.|.|..:.|:...:..:|..:.|.|.....|||.|
Mouse  1104 AVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESL 1168

  Fly   598 KREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINF 662
                  :|.||                      ..:||||.:||||..|....|:| ||:.|:||
Mouse  1169 ------RNCDP----------------------PCVPYLGMYLTDLVFIEEGTPNY-TEDGLVNF 1204

  Fly   663 DKKRKEFEVLAQIKLLQGAANTYNLQADA-----LFDHWFNSMPVFDEREAFELSCRLEPPPP 720
            .|.|....::.:|:..|  ..||.:....     |.|..|    :.||...:|.|..:||..|
Mouse  1205 SKMRMISHIIREIRQFQ--QTTYKIDPQPKVIQYLLDESF----MLDEESLYESSLLIEPKLP 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RglNP_001261814.1 REM 246..378 CDD:100121 40/222 (18%)
RasGEF 454..719 CDD:214539 75/270 (28%)
RalGDS_RA 858..946 CDD:176351
Rasgrf1NP_035375.1 PH-like 19..155 CDD:302622
PH 24..130 CDD:278594
RhoGEF 248..429 CDD:214619
PH-like 435..586 CDD:302622
PH 482..587 CDD:278594
RasGEF_N 638..>687 CDD:279012 18/49 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 714..738 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..854 5/53 (9%)
REM <927..996 CDD:295342 10/68 (15%)
RasGEF 1023..1259 CDD:214539 75/271 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.