Protein Alignment Rgl and Rasgrp2

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_035372.2
• Gene: Rasgrp2 / 19395
• MGIID: 1333849
• Length: 608
• Species: Mus musculus
• Alignment Length: 608
• Identity: 126/608 - (20%)
• Similarity: 212/608 - (34%)
• Gaps: 190/608 - (31%)

  Fly   298 LEEL-----EQAQQNGQVMDPA-----------YDPHASI-------HEQHKKTLVSALHV---- 335
            :|||     |....:|:|.||.           |.|.:.:       ::|.:|...::|.:
Mouse    13 VEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQQSRKDNSNSLQMKTCH 77

  Fly   336 ----WLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGH 396
                |:..||.::   :|...||...|.||             .|:.|           ..|..|
Mouse    78 LVRYWISAFPAEF---DLNPELAEQIKELK-------------ALLDQ-----------EGNRRH 115

  Fly   397 SWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFA 461
            |.|....|       :|| |.....:|.:           .|:.:....  .:..|.|:.....|
Mouse   116 SSLIDIES-------VPT-YKWKRQVTQR-----------NPVEQKKRK--MSLLFDHLEPMELA 159

  Fly   462 EQLTRMDTELFKRL--------IPHQCLGHTWARRDSGGSETVVATINQFNAVLFRVVSSILIDR 518
            |.||.::...|.::        :.|.|         :..:..:...|:.||:| .:.|..:::.:
Mouse   160 EHLTYLEYRSFCKILFQDYHSFVTHGC---------TVDNPVLERFISLFNSV-SQWVQLMILSK 214

  Fly   519 LKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLS-----------KIWEVLPKE 572
            ....:|||.|:.::.:|:.|..|:||::|.|::..|:.:||.||.           |:||.|
Mouse   215 PTATQRALVITHFVHVAERLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGL--- 276

  Fly   573 RMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLG 637
                 |||.......:|                          :.::|...:|.:     .|.||
Mouse   277 -----TELVTATGNYSN--------------------------YRRRLAACVGFR-----FPILG 305

  Fly   638 TFLTDLTMIHTANPDYLTENKL-INFDKKRKEFEVLAQIKLLQGAANTYNLQADAL------FDH 695
            ..|.||..:..|.||:|...:. :|..|.|:.|.:|.::.::...........|.|      .|.
Mouse   306 VHLKDLVALQLALPDWLDPGRTRLNGAKMRQLFCILEELAMVTSLRPPVQANPDLLSLLTVSLDQ 370

  Fly   696 WFNSMPVFDEREAFELSCRLEP-------------PPPAPRKSVVSTNTSLTNTTASSTASIMGH 747
            :..      |.|.::||.:.||             |||.|  .|:...||:....... |.:..|
Mouse   371 YQT------EDELYQLSLQREPRSKSSPTSPTSCTPPPRP--PVLEEWTSVAKPKLDQ-ALVAEH 426

  Fly   748 --RKTDSIHSN---SSSGAGSQFYCEL---NSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLD 804
              :..:|:..|   ...|..||...::   |....|....||::    ....:|....:|.....
Mouse   427 IEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQN----QDGCISREEMISYFLRS 487

  Fly   805 SSNSGGRQSGKLTHSQSMGNGLK 827
            ||..|||..  ..|:....|.|:
Mouse   488 SSVLGGRMG--FVHNFQESNSLR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	23/110 (21%)
		RasGEF	454..719	CDD:214539	63/303 (21%)
		RalGDS_RA	858..946	CDD:176351
Rasgrp2	NP_035372.2	RasGEFN	7..121	CDD:214571	28/134 (21%)
		RasGEF	150..387	CDD:214539	63/291 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..405		6/24 (25%)
		EFh	430..481	CDD:238008	10/54 (19%)
		C1	499..548	CDD:237996	3/10 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..596

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910