DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and Rapgef6

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_006532623.1	Gene:	Rapgef6 / 192786	MGIID:	2384761	Length:	1614	Species:	Mus musculus

Alignment Length:	1058	Identity:	196/1058 - (18%)
Similarity:	310/1058 - (29%)	Gaps:	463/1058 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 KVRYHRPTPTASNDSDDEI----SHLEWE---TVRVRFVKAATLARLVEALATDDGELESTFINV 268
            ::..|....|...:.:.||    .|.|.:   |.:...|..||..||:..|..:...::.|:|..
Mouse   378 RILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIED 442

  Fly   269 FLSTYRTF-STPKQV-LSLLTQ-RYDALHEK------------------------HLEE----LE 302
            ||.||||| .||..| :.||.. :.|.|.:|                        .|||    ||
Mouse   443 FLLTYRTFLETPLDVGIKLLEWFKIDNLRDKVTRIVLLWVNNHFNDFEGDPAMTQFLEEFERNLE 507

  Fly   303 QAQQNG--QVMDPAYDPHASIHE--QHKKTLVSALHVWLDGFPE--------------------- 342
            ..:.||  ::::.|....|...:  ..|.:..|.||..|.|..|
Mouse   508 DTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLHFCLTGGSEKGFGVFVEEVESGSKAADAGL 572

  Fly   343 -------DWHEDNLQQILAFATKRLKRSDLHI------------KVLNRLER------------- 375
                   :.:..|.:.|.......:.|::.|:            ::|:|.|:
Mouse   573 KRGDQVMEVNGQNFENITLAKALEILRNNTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAE 637

  Fly   376 -------------------------------------------------LIKQSLYGNGGGSG-- 389
                                                             ::...|:.:||.|.
Mouse   638 KKSNRHSIQDVPGDMEQAPQEKGNKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQ 702

  Fly   390 -----GSENNGHS--------WLSAARSQQMQ------QFMIPTHYGSSYDLTDQFNGMY----- 430
                 |:.:..||        .||::....:|      .|..|:..|..| :.||...::
Mouse   703 DDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSAVGFYY-IPDQVIRVFKADQQ 766

  Fly   431 --------------------------------------LSPMGHGPIYRGPTHF----------- 446
                                                  ::|.|.....|.|..|
Mouse   767 SCYIIISKDTTAKEVVCQAVQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNG 831

  Fly   447 ---------------------------LQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHT 484
                                       |...:...:.|   |.||:..|.:||:.:.|.:.:...
Mouse   832 RYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEV---ATQLSMRDFDLFRNIEPTEYIDDL 893

  Fly   485 WARRDSGGSETVVATINQF----NAVLFRVVSSILID--RLKPQERALNISRWIDIAQELRMLKN 543
            : :.||....|   .:.||    |...|.|.|.||.:  :||   |...|..:|.||...|..||
Mouse   894 F-KLDSKTGNT---HLKQFEDIVNQETFWVASEILSESNQLK---RMKIIKHFIKIALHCRECKN 951

  Fly   544 FSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDP 608
            |:|:.||||.||...:.||...||.||.:..:...:|.::.....|....|.:|
Mouse   952 FNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNIL----------- 1005

  Fly   609 GSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKR---KEFE 670
                |.:.:|..|           ||.......|:|.:|..|...:  :.|:||:|.|   ||..
Mouse  1006 ----SSQSMQPPI-----------IPLFPVVKKDMTFLHEGNDSKV--DGLVNFEKLRMIAKEIR 1053

  Fly   671 VLAQI----------------------KLLQGAANTYN-----------------LQADALFD-- 694
            .:.::                      .|.||:.|:..                 |.|..|::
Mouse  1054 HIIRMTSANMDPAMMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDA 1118

  Fly   695 -------HWFNSMPVFDEREAFE-LSCRLEPP-------------------PPAPRKSVVST--- 729
                   .:.:|:.:..:.|.|: :|.:.||.                   .|.|.:||..|
Mouse  1119 QMARKVKQYLSSLDIDTDEEKFQMMSLQWEPAYGTLTKNLTEKRSAKSSEMSPVPLRSVGQTAKV 1183

  Fly   730 ---------------------------------NTSLTNTTASSTASIMGHRKTDSIHSNSSSGA 761
                                             :|||.......|..:...:.|:...|.:||..
Mouse  1184 HLHQPHRVSQVLQVPAVNLHPIRKKGQAKDHVLSTSLPQKGLGPTEEVSVKKHTEDTISVASSLH 1248

  Fly   762 GSQFYCELNS-------STSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSGGRQ------- 812
            .|......||       :.||:.::|.   ...|:.:.|.||.|||.|:||.::.|:.
Mouse  1249 SSPPASPQNSPRKGYTLTPSSKCDNLS---DSSHSEISSRSSIVSNGSVDSMSAAGQDERCSSHS 1310

  Fly   813 ----------------SGKLTHSQ--------------------SMGNGLKSH------------ 829
                            ||...|||                    |:.:...||
Mouse  1311 LAVPEPTGALEKTDHPSGISDHSQLAHGWMLSKPCLIKGVAVSSSLSSEEMSHEHVVLEAADSGR 1375

  Fly   830 GNGTTNGGSPHINAQLVQ 847
            |:.|:...|.|.|.|.:|
Mouse  1376 GSWTSCSSSSHDNFQSLQ 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	44/268 (16%)
		RasGEF	454..719	CDD:214539	76/341 (22%)
		RalGDS_RA	858..946	CDD:176351
Rapgef6	XP_006532623.1	CAP_ED	37..>82	CDD:381773
		CAP_ED	280..380	CDD:237999	0/1 (0%)
		RasGEFN	412..525	CDD:214571	31/112 (28%)
		PDZ_signaling	529..609	CDD:238492	11/79 (14%)
		RA_PDZ-GEF1	756..838	CDD:340483	6/81 (7%)
		RasGEF	862..1086	CDD:238087	65/261 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900