DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and rgl-1

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001123140.1	Gene:	rgl-1 / 180611	WormBaseID:	WBGene00017891	Length:	880	Species:	Caenorhabditis elegans

Alignment Length:	947	Identity:	291/947 - (30%)
Similarity:	417/947 - (44%)	Gaps:	241/947 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 RLWGEEHEKNAIFTVYLKKVRYHRP--------------------------------TPTASNDS 225
            |.||:|...:||:.|||:||||..|                                .|......
Worm     4 RYWGDEKHPDAIYAVYLRKVRYVPPQGYEGVPQYHMQYFTFDKITRNFSRLPRYRAIDPDRPKTE 68

  Fly   226 DDEIS---HLEWETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLT 287
            ..|:|   |||||:|:.:.:||.|:.||||.|...|..::|...|||.:|||:|:....||..|.
Worm    69 SSEMSGADHLEWESVKEKLIKAGTVERLVECLVGSDDMMDSRHFNVFFATYRSFTDSAIVLDCLL 133

  Fly   288 QRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDN---- 348
            :||:.|         :.:.||..       .|.:.:...:.:|..   ||:.:|||:::.:
Worm   134 RRYETL---------ENEVNGST-------SALLVQNSIRQIVMC---WLETYPEDFYDSDKDFA 179

  Fly   349 -LQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMI 412
             |..:|.|. .|.|.::|..|.  |.:|.:.:.:|..||                     .|..:
Worm   180 MLSSLLDFG-GRNKLTELRAKA--RKQREVFKRIYDEGG---------------------MQAAL 220

  Fly   413 PTHYGSSYDLTDQFNGMYLSPMGHGPI-YRGPTHFLQAFRFPHVPVRH---FAEQLTRMDTELFK 473
            |:            .|.|::.||..|. |  |.:..:..:...|...:   .|||||..|..|||
Worm   221 PS------------LGQYVADMGFDPSDY--PNNIKERVKMFDVGKENCVQIAEQLTFWDAALFK 271

  Fly   474 RLIPHQCLGHTWARRDSGGSE--TVVATINQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQ 536
            .|:.|||.|..|::|.:.|..  ||.|||.|||:|..||::||::...:|:.||..||:|||||:
Worm   272 ELLIHQCQGCVWSKRRTAGERVYTVKATIEQFNSVSQRVMTSIVLPDCRPEYRAKIISKWIDIAR 336

  Fly   537 ELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANI--CSEDNNAWTLREVLKR 599
            |||.|||||||||::|:|.|..::||...|..:|...:..|.||::|  ..||.:....|::|::
Worm   337 ELRALKNFSSLKAVLSSLQSEPVHRLKSAWNSVPNRSISQFRELSSIYETDEDGDQGNARKILEQ 401

  Fly   600 EGTAKNPDPGSDHSDRHLQKLILNLGTQTS-------HGTIPYLGTFLTDLTMIHTANPDYLTEN 657
            |||||:       |.....:||.|.....|       .||:||||.|||||.|:..:.|||..||
Worm   402 EGTAKS-------SPLRRPQLIQNCRRTKSDVNLAECQGTVPYLGNFLTDLAMVDESTPDYTPEN 459

  Fly   658 KLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPP--P 720
             ||||:|:||||||||:::|.|.||..||:..|.:|..||..:|..||.|.|..|..:|.||  .
Worm   460 -LINFEKRRKEFEVLAKLRLFQSAARAYNIPMDRMFCAWFFFLPCLDENECFNRSLEIEKPPMHS 523

  Fly   721 APRKSVVSTNTS-LTNTTAS-----STASIMGHRKTDSIHSNSSSGAGS--QFYCELNSSTSSRH 777
            .|..|....|:| |:|.:.|     ||.|.:.:....|..|.|.:|.|:  |.....:|||:|:.
Worm   524 TPDLSSSRINSSMLSNGSQSTPVKNSTLSRLFNSSRTSEDSGSHNGNGTWHQHSHSYSSSTNSQI 588

  Fly   778 NSLDRDVHHQHASLMSASSSVSNLSLDSS----------NSGGRQ-----SGKLTHSQSMGNGLK 827
            .|::..     :||..:...|...|.||.          ..||..     ||..|..:.......
Worm   589 PSINTG-----SSLNISDGGVPQHSRDSGLQCEDWIDGRLDGGPPGPVPLSGTSTLPRGSNTNTP 648

  Fly   828 SHGNGTTNGGS--------PHINA---------QLVQPSSGTPHSAP------------------ 857
            |..|.:..|||        |:.::         |.|:.|..|..||.
Worm   649 SSANASWTGGSEFTPSSLFPYSHSRSKSGESSLQEVKTSMSTRASADGTSGTQSLSRSATPIRTR 713

  Fly   858 --------------------------------------DFYIIRVTYETDNIELDGIVLYKSIML 884
                                                  .||:.||..:.|....|| ..||.|.:
Worm   714 LAEVFDSKVFSHQKKGSDASSCSSSSSLSANGNSQAQNSFYLARVGLDDDLQNTDG-ANYKCIKI 777

  Fly   885 GNNERTPQVIRNAMLKLGLEDDPDRFTLAQVLP-DKELVMPKNANVYYAV---NTNYNLNFILRP 945
            .|.:|.||::..|:.|..:|||.:.:.|.|:|| ..|.|:|.|.|.:||:   .|:..||.:||.
Worm   778 ENGDRMPQLVARALEKHLIEDDKNTYLLVQLLPRGGEFVLPDNCNPFYAMAPDPTSPMLNLLLRK 842

  Fly   946 RKEEG-VAGSXS-----TAVPLSQL-------WCLGY 969
            |...| :.|..|     :|..|:::       |..||
Worm   843 RDGNGTIEGGASPQLGPSAKKLNRMKRTNLLRWSSGY 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	39/136 (29%)
		RasGEF	454..719	CDD:214539	125/278 (45%)
		RalGDS_RA	858..946	CDD:176351	35/91 (38%)
rgl-1	NP_001123140.1	RasGEFN	84..211	CDD:214571	41/148 (28%)
		RasGEF	254..515	CDD:238087	123/268 (46%)
		UBQ	752..843	CDD:294102	35/91 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166922
Domainoid	1	1.000	175	1.000	Domainoid score	I2189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9039
Inparanoid	1	1.050	302	1.000	Inparanoid score	I1611
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45636
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	1	1.000	-	-		FOG0003345
OrthoInspector	1	1.000	-	-		oto20190
orthoMCL	1	0.900	-	-		OOG6_106137
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3106
SonicParanoid	1	1.000	-	-		X1296
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940