DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rgl and Rasgrf2

DIOPT Version :10

Sequence 1:NP_001261814.1 Gene:Rgl / 44115 FlyBaseID:FBgn0026376 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_446173.2 Gene:Rasgrf2 / 114513 RGDID:69413 Length:1189 Species:Rattus norvegicus


Alignment Length:658 Identity:143/658 - (21%)
Similarity:226/658 - (34%) Gaps:202/658 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   197 EEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGEL 261
            ||:.|..:..:.....|.|:       |..|........:.:|..::.|::.||:|.| ||...|
  Rat   601 EENSKVTVPHMIKSDARLHK-------DDTDICFSKTLNSCKVPQIRYASVERLLERL-TDLRFL 657

  Fly   262 ESTFINVFLSTYRTFSTPKQVLSLLTQRY----DALHEKHLEELEQAQQNGQ------------- 309
            ...|:|.||.|||.|:|...||..|:..|    .::..:.||......||.:             
  Rat   658 SIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCR 722

  Fly   310 ------------------------------------------------VMDPAYD--PHASIHE- 323
                                                            |..||..  ||.::.| 
  Rat   723 KFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTTSSSSSSPTTVHSPAASPPPHTAVPES 787

  Fly   324 ----------------------QHKK------------------------TLVSALHVWLDGFPE 342
                                  :|.:                        ...:|.|....||..
  Rat   788 APADRAGDSTDMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNN 852

  Fly   343 DWHEDNLQQILAFATKRL----------------KRSDLHIKVLNRLERLIKQ-SLYGNGGGSGG 390
            :...|....|...||.|:                ..::|.:.|||.||.:::. .|.       .
  Rat   853 ERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLL-------P 910

  Fly   391 SENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHV 455
            .|....:.:..|.||. .|..|.........:||       .|              :|..|..:
  Rat   911 QERKATANILRALSQD-DQDDIHLKLEDIIQMTD-------CP--------------KAECFETL 953

  Fly   456 PVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSG-GSETVVATINQFNAVLFRVVSSILIDRL 519
            .....|||:|.:|..:|:.:...:.||..|.:.|.. .:..::.|...||. :..:|:|.:::..
  Rat   954 SAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNE-MSNLVASQIMNYA 1017

  Fly   520 KPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANIC 584
            ....||..|.:|:.:|...|.|.|::.:..|.||||.::||||.|.|..:.|:...:..:|....
  Rat  1018 DISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTV 1082

  Fly   585 SEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTA 649
            |.:.....|||      |.||.:|.:                      :||||.:||||..|...
  Rat  1083 SSEGRFKNLRE------TLKNCNPPA----------------------VPYLGMYLTDLAFIEEG 1119

  Fly   650 NPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNL-QADALFDHWFNSMPVFDEREAFELSC 713
            .|:: ||..|:||.|.|....::.:|:..|..|  |.: |...:..:..:...|.||...:|||.
  Rat  1120 TPNF-TEEGLVNFSKMRMISHIIREIRQFQQTA--YRIDQQPKVIQYLLDKALVIDEDTLYELSL 1181

  Fly   714 RLEPPPPA 721
            ::||..||
  Rat  1182 KIEPRLPA 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RglNP_001261814.1 REM 246..378 CDD:100121 46/261 (18%)
RasGEF 454..719 CDD:214539 74/266 (28%)
RA_RalGDS_like 858..946 CDD:340449
Rasgrf2NP_446173.2 PH_RasGRF1_2 19..158 CDD:270081
RhoGEF 247..428 CDD:214619
PH 480..587 CDD:459697
RasGEF_N 638..>686 CDD:459873 20/48 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..744 0/30 (0%)
Regulates proteasomal degradation. /evidence=ECO:0000250 743..751 0/7 (0%)
REM <852..924 CDD:470601 14/78 (18%)
RasGEF 950..1186 CDD:214539 74/267 (28%)
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 1051..1080 11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

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