Protein Alignment Rgl and RAPGEF3

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_011536054.1
• Gene: RAPGEF3 / 10411
• HGNCID: 16629
• Length: 938
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 163/738 - (22%)
• Similarity: 251/738 - (34%)
• Gaps: 271/738 - (36%)

  Fly   134 SSYHSYDDLDVSSAVLNAERKVVASLKY-LCACTGATLRNLSKKTKDLHAKNYTYTKPTWRLWGE 197
            ::.|..||....:.|.:|.|.....|:. .|.......::.::..||:.||       |.||  |
Human   317 TTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAK-------TMRL--E 372

  Fly   198 EHEKNAIFTVYLKKVRY-----HRPTP-----TASNDSDDEISHLEWETVRVRFVKAATLARLVE 252
            ||.|   ..:.|::...     ..|||     |..:.:.::|..|                 |:|
Human   373 EHGK---VVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILEL-----------------LLE 417

  Fly   253 ALATDDG--ELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAY 315
            |:..|..  :...||::.||.|:|.|....|:.:.|      ||..|:|....::|....
Human   418 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAAL------LHHFHVEPAGGSEQERST----- 471

  Fly   316 DPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRL-KRSDLHIKVLNRLERLIKQ 379
              :.....|....|||.   |:..:....|.|.:      ||..| |.||| :....||..|:::
Human   472 --YVCNKRQQILRLVSQ---WVALYGSMLHTDPV------ATSFLQKLSDL-VGRDTRLSNLLRE 524

  Fly   380 S--------LYGNGGGSGGSENNGHS---WLSAARSQQMQQFMIPTHYGSS----------YD-- 421
            .        ...||.|:...:....:   ||      ..|...:|   |||          ||
Human   525 QWPERRRCHRLENGCGNASPQMKARNLPVWL------PNQDEPLP---GSSCAIQVGDKVPYDIC 580

  Fly   422 ------LTDQF--------------------NGMYL-------SPMGHGPIYRG----------- 442
                  ||.|.                    .|..|       ..:|..|..||
Human   581 RPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERL 645

  Fly   443 ------PTHFLQAFRFPH----------------VPVRHFAEQLTRMDTELFKRL----IPHQCL 481
                  ..|.|    .||                |..:..|.|||..|..||..:    :.|..|
Human   646 FVVNPQEVHEL----IPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVL 706

  Fly   482 G--HTWARRDSGGSETVVATIN------QFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQEL 538
            |  |.   ||       |.|.|      :||.:.:.|.:.:.:..: |..||..:.::|.:|..|
Human   707 GPQHL---RD-------VTTANLERFMRRFNELQYWVATELCLCPV-PGPRAQLLRKFIKLAAHL 760

  Fly   539 RMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTA 603
            :..||.:|..|::..|::::|.||:..||.||.:..::::.|..:.
Human   761 KEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLL------------------- 806

  Fly   604 KNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKE 668
               ||..:|   .:.:|.|   .:.|...||::...|.|:|.||..| ..|.|| ||||:|.|
Human   807 ---DPSWNH---RVYRLAL---AKLSPPVIPFMPLLLKDMTFIHEGN-HTLVEN-LINFEKMR-- 858

  Fly   669 FEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPPPP-APRKSVVS---- 728
              ::|              :|..:..|                 ||...|.| :|.:|.||
Human   859 --MMA--------------RAARMLHH-----------------CRSHNPVPLSPLRSRVSHLHE 890

  Fly   729 ----------TNTSLTNTTASST 741
                      :..||:..:.:||
Human   891 DSQVARISTCSEQSLSTRSPAST 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	35/134 (26%)
		RasGEF	454..719	CDD:214539	68/292 (23%)
		RA_RalGDS_like	858..946	CDD:340449
RAPGEF3	XP_011536054.1	DEP_Epac	100..238	CDD:239884
		CAP_ED	262..371	CDD:237999	13/60 (22%)
		REM	407..526	CDD:100121	37/158 (23%)
		RasGEF	673..905	CDD:238087	73/307 (24%)