Protein Alignment Rgl and RASGRP2

DIOPT Version :10

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_011543020.1
• Gene: RASGRP2 / 10235
• HGNCID: 9879
• Length: 715
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 123/562 - (21%)
• Similarity: 196/562 - (34%)
• Gaps: 167/562 - (29%)

  Fly   321 IHEQHKKTLVSALHV--------WLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLI 377
            |::|.:|...::|.|        |:..||.::   :|...||...|.||             .|:
Human   164 IYQQSRKDNSNSLQVKTCHLVRYWISAFPAEF---DLNPELAEQIKELK-------------ALL 212

  Fly   378 KQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRG 442
            .|           ..|..||.|....|       :|| |.....:|.:           .|:  |
Human   213 DQ-----------EGNRRHSSLIDIDS-------VPT-YKWKRQVTQR-----------NPV--G 245

  Fly   443 PTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRL--------IPHQCLGHTWARRDSGGSETVVAT 499
            ......:..|.|:.....||.||.::...|.::        :.|.|         :..:..:...
Human   246 QKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGC---------TVDNPVLERF 301

  Fly   500 INQFNAVLFRVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLS- 563
            |:.||:|...|...||.....|| |||.|:.::.:|::|..|:||::|.|::..|:.:||.||.
Human   302 ISLFNSVSQWVQLMILSKPTAPQ-RALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKE 365

  Fly   564 ----------KIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQ 618
                      |:||.|        |||........|                          :.:
Human   366 THSHVSPETIKLWEGL--------TELVTATGNYGN--------------------------YRR 396

  Fly   619 KLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKL-INFDKKRKEFEVLAQIKLLQGAA 682
            :|...:|.:     .|.||..|.||..:..|.||:|...:. :|..|.::.|.:|.::.::....
Human   397 RLAACVGFR-----FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLR 456

  Fly   683 NTYNLQADAL------FDHWFNSMPVFDEREAFELSCRLEP-------------PPPAPRKSVVS 728
            .......|.|      .|.:..      |.|.::||.:.||             |||.|  .|:.
Human   457 PPVQANPDLLSLLTVSLDQYQT------EDELYQLSLQREPRSKSSPTSPTSCTPPPRP--PVLE 513

  Fly   729 TNTSLTNTTASSTASIMGH--RKTDSIHSN---SSSGAGSQFYCEL---NSSTSSRHNSLDRDVH 785
            ..||........ |.::.|  :..:|:..|   ...|..||...::   |....|....||::
Human   514 EWTSAAKPKLDQ-ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQN-- 575

  Fly   786 HQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSMGNGLK 827
              ....:|....||.....||..|||..  ..|:....|.|:
Human   576 --QDGCISREEMVSYFLRSSSVLGGRMG--FVHNFQESNSLR 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	15/64 (23%)
		RasGEF	454..719	CDD:214539	66/303 (22%)
		RA_RalGDS_like	858..946	CDD:340449
RASGRP2	XP_011543020.1	RasGEF	255..492	CDD:214539	66/291 (23%)
		FRQ1	<512..589	CDD:444056	16/81 (20%)
		C1	601..656	CDD:412127	3/15 (20%)