DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and LOC101885008

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_009301754.2	Gene:	LOC101885008 / 101885008	-ID:	-	Length:	716	Species:	Danio rerio

Alignment Length:	763	Identity:	246/763 - (32%)
Similarity:	359/763 - (47%)	Gaps:	164/763 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 ESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHK 326
            :||::.:||.|||||:|.||||.||..||..|         |.|....|.....|....:    :
Zfish     9 DSTYVTIFLCTYRTFATTKQVLDLLLNRYAKL---------QQQPGPDVRRMTSDERTEL----R 60

  Fly   327 KTLVSALHVWLDGFPED-WHEDN---LQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGG 387
            .|:.|.|..|||.:.|| |....   |::::.:.......|||..:..|.|...
Zfish    61 NTISSILGAWLDQYSEDFWKPPEYSCLRRLILYLQINFPGSDLERRACNLLSHF----------- 114

  Fly   388 SGGSENNGHSWLSAARSQQMQQ----FMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQ 448
                    |..|..|....::|    |.:....|...:..|     :||
Zfish   115 --------HRRLQHAEPDLLEQGCCAFSLLEENGFEEERPD-----FLS---------------- 150

  Fly   449 AFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATINQFNAVLFR 509
               |....|   |||.|.||.|||||::|:.|||..|::||..|.|    |:.||::|||.|...
Zfish   151 ---FDPTVV---AEQFTLMDAELFKRVVPYHCLGSIWSQRDKKGKEHLAPTIRATVSQFNRVTNC 209

  Fly   510 VVSSILIDR-LKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKER 573
            .:::.|.|| ||...||..:..||.:|:|.|:|||||||:||:|||..|.::||.|.|:.:.:|.
Zfish   210 AIATCLSDRTLKHTHRARILEHWIQVARECRILKNFSSLRAILSALQCNPVHRLKKTWDEVSREN 274

  Fly   574 MEVFTELANICSEDNNAWTLREVLKREGTAK------NPDPGSDHSDRHLQKLILNLGTQTSHGT 632
            :.:|.||:.|.|::||....||:|.:|||:|      ||........|.|..:         .||
Zfish   275 LRIFQELSEIFSDENNHSLSRELLIKEGTSKFATLEINPKRAQKRQQRDLTVM---------QGT 330

  Fly   633 IPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWF 697
            |||||||||||.|:.||..||| :..||||:|:||||||:|||||||.|.|.||.|..:.|..|.
Zfish   331 IPYLGTFLTDLVMMDTAMKDYL-DGGLINFEKRRKEFEVIAQIKLLQLACNNYNFQRVSGFSAWL 394

  Fly   698 NSMPVFDEREAFELSCRLEPPPPAPRKSVVSTNTS------------LTNTTASSTASIMGHRKT 750
            .|:....|.|::..||.:||...:...::.:..:|            .......|::|...|.|:
Zfish   395 CSVEKLSEAESYSQSCEIEPLSESASNTLRAKKSSGIMKRWSDRQPVCVGEAGCSSSSGSSHSKS 459

  Fly   751 -------------------DSIHSNSSSGAGSQFYCELN-SSTSSRHNSLDRD-----VHHQHAS 790
                               ||: |.:|:|:.|....|:| |.||...::.:|.     |.|.:::
Zfish   460 FDQLRFPVCVSGGSVCDGGDSV-SVTSAGSSSSDVEEVNISYTSESPDAPERKTSTPFVKHSNST 523

  Fly   791 LMSA------------SSSVSNLSLDSSNSGGRQSGKLTHS-----QSMGNGLKSHGNGTTNGGS 838
            |...            |:|:|:|...:..||...|...:.|     .|:....|...:|.::..|
Zfish   524 LGKCGPSGDLIPTFWESTSLSSLDASALGSGSGSSSASSSSVSSTPVSVSRSHKRSASGVSSYSS 588

  Fly   839 ---PHINAQLVQPSSGTPHSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLK 900
               |..|.|:           .|..||||:.:.||..     :||||::.:.::||.|:|.||:|
Zfish   589 LSLPLYNQQV-----------DDCCIIRVSLDVDNGN-----MYKSILVTSQDKTPAVVRKAMVK 637

  Fly   901 LGLE-DDPDRFTLAQ-VLPDKELVMPKNANVYYAVNTNYNLNFILRPR 946
            ..|: :..:.:.|.| :..:|||.:|.||||:||:|:..|.:|:|:.|
Zfish   638 HNLDRERAEDYELVQKISEEKELKIPDNANVFYAMNSTANYDFVLKKR 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	38/119 (32%)
		RasGEF	454..719	CDD:214539	127/275 (46%)
		RalGDS_RA	858..946	CDD:176351	35/89 (39%)
LOC101885008	XP_009301754.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010