DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and sos2

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_002938172.3	Gene:	sos2 / 100497015	XenbaseID:	XB-GENE-1006170	Length:	1333	Species:	Xenopus tropicalis

Alignment Length:	936	Identity:	191/936 - (20%)
Similarity:	343/936 - (36%)	Gaps:	268/936 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 WRQVNNNTTSQSCAYHQQRQQQQ--QQQDAKD-----------------SKRHYHH--------H 93
            ||..|....|:..|..:..:.|:  ...:.||                 ..:|..|        .
Frog   404 WRLYNRQMRSKHVAIKKMNEIQKNIDSWEGKDIGQCCNEFIMEGSLTRVGAKHERHIFLFDGLMI 468

  Fly    94 TCPRQRKKSMTPVEPTHLCQKHQEAKQRRSRSASAKPRRNSSYH-------SYDDLDVSSAVLNA 151
            :|.....:|..|...|   .:::..::...|......:.::|.:       |.|:..:..|...|
Frog   469 SCKMNHGQSRIPGYNT---AEYRLKEKLIMRKVQINDKEDTSEYKNAFELLSKDENSIVFAAKTA 530

  Fly   152 ERK-----VVASLKYLCACTGATLRNLSKKTKDLHAKNYTYTKP-------TWRLWGEEHEKNAI 204
            |.|     .:.||:|         |::..:..|.........:|       .:|...|:.|:|.:
Frog   531 EEKNNWMAALISLQY---------RSMLDRMLDTVLIQEENEQPLRLPSPDVYRFVEEDSEENIV 586

  Fly   205 FTVYLKKVRYHRPTPTASNDSDDEISHLEWETVRVRFVKAATLARLVEALATDDGELESTFINVF 269
            |                    :|.:.    ....:..:|..|:.:|:|.| |.....:..|:..|
Frog   587 F--------------------EDSVQ----SRSGIPIIKGGTVVKLIERL-TYHMYADPNFVRTF 626

  Fly   270 LSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALH 334
            |:|||:|..|:::|:||.:|::      :.:.|..:.:...::....|.::..::.:|..|..:.
Frog   627 LTTYRSFCKPQELLNLLIERFE------IPDPEPTESDKMAIEKGEQPISANLKRFRKEYVQPVQ 685

  Fly   335 V--------WLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGS 391
            :        |::....|:..|                   :::|:|||..|             |
Frog   686 LRVLNVFRHWVEHHFYDFERD-------------------LELLDRLESFI-------------S 718

  Fly   392 ENNGHS---WLSA-----ARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQ 448
            ...|.|   |:.:     .|.:|.|.      .|.|:::|      :.||......:...|...:
Frog   719 NVRGKSMKKWVESIAKIIRRKKQAQA------NGVSHNIT------FESPFPPIEWHISRTGQCE 771

  Fly   449 AFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSETVVATINQFNAV-LFRVVS 512
            .|....:.....|.|||.|:::|::.:.|.:.:|..|.:.|.        .||..|.: :.|..:
Frog   772 TFDLMTLHPIEIARQLTLMESDLYRAVQPSELVGSVWTKEDK--------EINSPNLLKMIRHTT 828

  Fly   513 SI-------LIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLP 570
            ::       |::....:||....||.|:|.|..:.|.||:.:..|:||:||..:|||...:|.|.
Frog   829 NLTLWFEKCLVETENFEERVAVFSRIIEILQVFQELNNFNGVLEIVSAVNSVPVYRLDHTFEALQ 893

  Fly   571 KERMEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPY 635
            :.:.::..|...:                         ..||..::|.||     ...:...:|:
Frog   894 ERKKKILDEAVEL-------------------------SQDHFKKYLAKL-----KSINPPCVPF 928

  Fly   636 LGTFLTDLTMIHTANPDYLTE--NKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWFN 698
            .|.:||::......|||:|..  .:||||.|:||..|:..:|:..|.  ..|.|:.:|....:|.
Frog   929 FGIYLTNILKTEEGNPDFLKRQGKELINFSKRRKVAEITGEIQQYQN--QPYCLRTEADIQRFFE 991

  Fly   699 SM-PV--FDERE----AFELSCRLEP-----PPPAPRKSVVSTNTSLTNTTA----SSTASIMGH 747
            :: |:  |.|:|    .|..|..:||     ||...||:..|..:......:    ||:.::.||
Frog   992 NLNPIGNFGEKEFTDYLFNKSQEIEPRNCKQPPRFSRKTTYSLKSPGIRPNSGRHLSSSGTLRGH 1056

  Fly   748 --------------RKTDSIHSNSSSGAGSQFYCELNSSTSSRHNS--LDRDVHHQHASLMSASS 796
                          |.|:|.|.::.|...|........:::|...|  :|.|:|    |...:|:
Frog  1057 PMPLEREPYKISFSRITESDHESTISPPISPNTPSTPPASASSELSVFVDLDLH----SSFGSST 1117

  Fly   797 SVSNLSLDSSNSGGRQSGKLTHSQS-----------------MGNGLKSHGNGTTNGGSPHINAQ 844
            .:|:..|.:|.|.....|.| |..|                 .|:.|..|..  .:...|.|..:
Frog  1118 MLSHGFLPNSKSFFSSCGSL-HRLSEEPLLPPPLPPRRKVDPEGSNLVGHSK--LDDDPPAIPPR 1179

  Fly   845 L-----VQPS--------SGTPHSAP 857
            |     :||.        .|..||.|
Frog  1180 LPPPPKIQPRVPAYTGPFDGPLHSPP 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	28/139 (20%)
		RasGEF	454..719	CDD:214539	71/286 (25%)
		RalGDS_RA	858..946	CDD:176351	191/936 (20%)
sos2	XP_002938172.3	Histone	70..169	CDD:333859
		RhoGEF	200..382	CDD:238091
		PH_SOS	438..544	CDD:269963	15/108 (14%)
		RasGEFN	596..740	CDD:214571	35/182 (19%)
		RasGEF	775..1014	CDD:238087	69/278 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910