DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and zbtb22

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_002938727.2	Gene:	zbtb22 / 100488727	XenbaseID:	XB-GENE-6458515	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	166	Identity:	36/166 - (21%)
Similarity:	55/166 - (33%)	Gaps:	47/166 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSA---LH--VWLDG-----FPEDWHEDNLQQI 352
            ||.|.|.:..|::.|.:......:...|:..|.::   .|  |.|.|     .|........:.:
Frog    20 LESLNQQRMEGKLCDVSIHAQGRVFRAHRAVLAASSPYFHDQVLLKGMSSVSLPGVVDPGAFEAV 84

  Fly   353 LAFA-TKRLKR------------SDLHI-KVLNRLERLIKQSLYGNGGG--SGGSENNGHSWLSA 401
            |..| |.||..            |.|.: .|:::...|:|:|..||..|  .|.....|
Frog    85 LCAAYTGRLTMLADEIVNYLTVGSVLQMWHVVDKCSELLKESRGGNSCGIVEGAGSTTG------ 143

  Fly   402 ARSQQMQQFMIPT----HYGSSYDLTDQFNGMYLSP 433
                       ||    |.|.:.:.....:..|.||
Frog   144 -----------PTPQRPHSGRASENQSPSSSNYFSP 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	22/103 (21%)
		RasGEF	454..719	CDD:214539
		RalGDS_RA	858..946	CDD:176351
zbtb22	XP_002938727.2	BTB_POZ_ZBTB22_BING1	12..123	CDD:349519	21/102 (21%)
		C2H2 Zn finger	339..358	CDD:275368
		zf-H2C2_2	352..374	CDD:372612
		zf-C2H2	364..386	CDD:333835
		C2H2 Zn finger	366..386	CDD:275368
		zf-H2C2_2	378..401	CDD:372612
		C2H2 Zn finger	394..418	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3248
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48328
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.040