DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgl and rgl3a

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_005165808.1	Gene:	rgl3a / 100149956	ZFINID:	ZDB-GENE-101130-1	Length:	785	Species:	Danio rerio

Alignment Length:	813	Identity:	252/813 - (30%)
Similarity:	373/813 - (45%)	Gaps:	156/813 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YTKPTWRLWGEEHEKNAIFTVYLKKVRYHR----PTPTASNDSDDEISHLEWETVRVRFVKAATL 247
            :|:...:.||||.|..||:.|.|     ||    |.|.|| :||.....:::.|::||.:|||||
Zfish    54 HTEDPVQEWGEEVEDGAIYGVTL-----HREPIQPPPDAS-ESDAAFGFMQYRTLKVRRLKAATL 112

  Fly   248 ARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMD 312
            .|||..|...:.. :..::::||||||.|:....::.||.||.|.:          ...|..|.
Zfish   113 DRLVTELVNPECP-DPDYMHIFLSTYRAFTCTNALIELLFQREDMV----------TNLNNSVC- 165

  Fly   313 PAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRSDLHIKVLNRLERLI 377
                        .|.:|...:.:|||.|.||..:....|.|......|:......:::|:.:.|:
Zfish   166 ------------VKSSLPRLIRLWLDEFHEDLRDSPDHQALRLLCVHLRHRLCCRRLVNQADALL 218

  Fly   378 KQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRG 442
            ::....:......:|.|.    ||..:...:               |..:|..:..:|
Zfish   219 RKFQTEDKQICTSAEVNA----SAVENPATE---------------DNLDGQEVQEIG------- 257

  Fly   443 PTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATINQF 503
                 ....|   |.:..|||||.:|.|||.:::|..|||..|::||...::    ||.|||.||
Zfish   258 -----DVLDF---PAQDIAEQLTILDAELFSKVVPFHCLGCIWSQRDKKENQNLVSTVRATIAQF 314

  Fly   504 NAVLFRVVSSIL------------IDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNS 556
            |.|...|::|:|            ..|..|..||..|.:||.:|||...|:|||||:||:|||.|
Zfish   315 NVVTNCVITSLLCPPATSPPGSPSCHRSSPTYRAKIIEKWISVAQECHQLRNFSSLRAILSALQS 379

  Fly   557 NSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLREVLKREG-------TAKNP-DPGSDHS 613
            |::|||.|.|.|:.:|.|.||..|.:...::|.....||:|..||       |...| .|....:
Zfish   380 NAVYRLKKTWAVISRESMAVFEHLCDTFPDENCVLINREILVEEGNQAADVETHSAPKSPRLSPT 444

  Fly   614 DRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLL 678
            .:|:|        .:|.|.:|||||:||.|||:.||..|.: |..||||:|:|||||:|:.|:.|
Zfish   445 CKHMQ--------SSSSGEVPYLGTYLTVLTMLDTALTDNV-EGGLINFEKRRKEFEILSLIRQL 500

  Fly   679 QGAANTYNLQADALFDHWFNSMPVFDEREAFELSCRLEPP----PPAPRKSVVSTNTSLTNTTAS 739
            |.:...|.||:......|.||.....:::::|||..||||    |.:|............|...|
Zfish   501 QASCAHYTLQSHPRIISWINSSMSLSDQKSYELSRELEPPVDPCPSSPNSWSHRLIAKKLNLLLS 565

  Fly   740 STASIMGHRKTDSIHSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHAS-----LMSASSSVS 799
            :|.:.......|.|..:||..:||..            ..|.||:...:.|     :.|.|.|..
Zfish   566 ATENFSRKTLADQISVSSSGSSGSDM------------EDLGRDLSSPNTSPLVYKVWSPSVSCQ 618

  Fly   800 NLSLDSSNSGGR--------------QSGKLTHSQSMGNGLKSHGNGTTNGGSPHINAQLVQPSS 850
            ::|:|:..|...              :|...|.|.|..:....|.....:   |..|.|:.
Zfish   619 DISVDTPTSSPTPPPSCQRSLQADLPESPSSTSSSSSSSSPSLHQRCALH---PMYNKQVA---- 676

  Fly   851 GTPHSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLED-DPDRFTLAQ 914
                   |..|:||:.|..|   :|.| ||||::.:.::|.||::.|:.|..||: :...|||.|
Zfish   677 -------DSCIVRVSVEFGN---NGNV-YKSILITSQDKTAQVVQRALEKHNLEEMNCQDFTLTQ 730

  Fly   915 VLP-DKELVMPKNANVYYAVNTNYNLNFILRPR 946
            ||. ||||::|..|||:||:.|..|.:|:||.|
Zfish   731 VLSNDKELLIPDKANVFYAMCTTANYDFVLRQR 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	33/131 (25%)
		RasGEF	454..719	CDD:214539	117/292 (40%)
		RalGDS_RA	858..946	CDD:176351	40/89 (45%)
rgl3a	XP_005165808.1	RasGEF_N	106..189	CDD:279012	31/106 (29%)
		RasGEF	259..541	CDD:214539	117/293 (40%)
		RalGDS_RA	677..763	CDD:176351	40/89 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3097
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1971
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	1	1.000	-	-		FOG0003345
OrthoInspector	1	1.000	-	-		otm25546
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1296
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.930