Protein Alignment Rgl and ralgds

DIOPT Version :9

• Sequence 1: NP_001261814.1
• Gene: Rgl / 44115
• FlyBaseID: FBgn0026376
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_012823402.1
• Gene: ralgds / 100135084
• XenbaseID: XB-GENE-987988
• Length: 856
• Species: Xenopus tropicalis
• Alignment Length: 927
• Identity: 296/927 - (31%)
• Similarity: 444/927 - (47%)
• Gaps: 231/927 - (24%)

  Fly   165 CTGATLRNL--------SKKTKDLHAKNYTYTKP--------TWRLWGEEHEKNAIFTVYLKKVR 213
            ||...:|:|        :.::..:...::|...|        |..: |||.:...|:::.|:||:
 Frog    23 CTARKMRSLWDGVRLEVAGESSPVVLSSFTQLDPDLPPLESSTQEI-GEEVDDGVIYSISLRKVQ 86

  Fly   214 YHR--------------PTP--------------TASNDSDDEISHLEWETVRVRFVKAATLARL 250
            .|.              |:|              |..|||...:    :||.:||.:||.||.:|
 Frog    87 LHHTANKGQRWLGVSRVPSPMGCADGGLAGLRDTTVENDSGLSL----YETCKVRSIKAGTLEKL 147

  Fly   251 VEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHLEELEQAQQNGQVMDPAY 315
            ||.|.:.....:||::.:||.|||.|:|.||||.||..|:..||         .|.||:
 Frog   148 VEYLVSAFKGNDSTYVTIFLCTYRAFATTKQVLDLLLNRFGRLH---------PQINGE------ 197

  Fly   316 DPHASIHE--QHKKTLVSALHVWLDGFPEDWHE----DNLQQILAFATKRLKRSDLHIKVLNRLE 374
            ..|.|:.:  :.|.|:.|.|..|||.:.||:.:    ..|:|::.:....:..|||..:..|.|.
 Frog   198 HSHNSVDDRLELKNTISSILGAWLDQYSEDFRQAPDYTCLKQLITYVRHNIPGSDLERRACNLLT 262

  Fly   375 RLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMIPTHYGSSYDLTDQFNGMYLSPMGHGPI 439
            :..:|.                  :||....      :..|...:..|.::       |:    :
 Frog   263 QFKRQQ------------------ISALEPD------VVDHTSCTLRLVEE-------PL----L 292

  Fly   440 YRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRLIPHQCLGHTWARRDSGGSE----TVVATI 500
            ..|...|| :||...:     |||.|.||.||||:::|:.|||..|::||..|.|    |:.||:
 Frog   293 SDGKPDFL-SFRQDML-----AEQFTVMDAELFKKVVPYHCLGCIWSQRDKKGKEHLAPTIRATV 351

  Fly   501 NQFNAVLFRVVSSILIDR-LKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSK 564
            :|||:|...|:|:.|.|| ||||:||..|.|||::|:|.|:|||||||:||:|||..|:|:||.|
 Frog   352 SQFNSVTNCVISTCLCDRSLKPQQRAKVIERWIEVARECRILKNFSSLRAILSALQCNAIHRLKK 416

  Fly   565 IWEVLPKERMEVFTELANICSEDNNAWTLREVLKREGTAK------NPDPGSDHSDRHLQKLILN 623
            .|:.:.:|...:|.||:.|.|::||....||:|.:|||:|      ||........:..:..::
 Frog   417 TWDEVSRESYRIFMELSEIFSDENNHSLSRELLIKEGTSKFATLDINPKRAQKRQQQQREMGVM- 480

  Fly   624 LGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQ 688
                  .|||||||||||||.|:.||..||| |:.||||:|:||||||:|||||||.|.|.|:..
 Frog   481 ------QGTIPYLGTFLTDLVMLDTAMKDYL-ESGLINFEKRRKEFEVIAQIKLLQSACNNYSFL 538

  Fly   689 ADALFDHWFNSMPVFDEREAFELSCRLEP-------------------------PPPA-PRKSVV 727
            .|..|..||:|:....|.|::.|||.:||                         ||.: |..||.
 Frog   539 PDESFVEWFHSVERLTEAESYSLSCEIEPLSESASNTLKAKKNTGIIKRWSDRQPPSSEPCPSVS 603

  Fly   728 STNTSLTNTTASSTASIMGHRKTDSIHSNSSSGAGSQFYCELNSS-------------------- 772
            |.:.|......|  ..:.|...|||: |.:|:|:.|....|:|.|
 Frog   604 SHSKSFDQLKCS--PHLCGGDTTDSL-SVTSAGSSSSDVDEINISFVPESPDCQEKKVREGPSQA 665

  Fly   773 ---------------TSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSGGRQSGKLTHSQSM 822
                           .|:..:|||.      :.:.|.|||.|:.|:.|:    ..|...||.:|:
 Frog   666 RPIQPAEPCVPEGFWESTSLSSLDT------SGIGSGSSSASSSSVSST----PVSASRTHKRSV 720

  Fly   823 GNGLKSHGNGTTNGGSPHINAQLVQPSSGTPHSAPDFYIIRVTYETDNIELDGIVLYKSIMLGNN 887
             :|:.|:.:.:.    |..|.|:           .|..||||:.:.||..     :||||::.:.
 Frog   721 -SGISSYSSLSL----PLYNQQI-----------DDCCIIRVSLDVDNGN-----MYKSILVTSQ 764

  Fly   888 ERTPQVIRNAMLKLGLEDD-PDRFTLAQVL-PDKELVMPKNANVYYAVNTNYNLNFILRPRK-EE 949
            ::||.|||.||.|..::.: .:.:.|.|:: .::||.:|.||||:||:|:..|.:|:|:.|. .:
 Frog   765 DKTPVVIRKAMAKHNIDGERAEDYELVQIISEERELKIPDNANVFYAMNSGANYDFVLKKRGFSK 829

  Fly   950 GV---AGSXSTAVPLSQ 963
            ||   .||.||...:.|
 Frog   830 GVKIKQGSSSTLPRMKQ 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121	45/137 (33%)
		RasGEF	454..719	CDD:214539	132/300 (44%)
		RalGDS_RA	858..946	CDD:176351	34/89 (38%)
ralgds	XP_012823402.1	RasGEFN	135..265	CDD:214571	49/144 (34%)
		RasGEF	299..564	CDD:238087	133/278 (48%)
		RA_RalGDS	740..825	CDD:340729	34/89 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3248
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2256
OMA	1	1.010	-	-		QHG45636
OrthoDB	1	1.010	-	-		D116220at33208
OrthoFinder	1	1.000	-	-		FOG0003345
OrthoInspector	1	1.000	-	-		otm48328
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1296
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080