DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgl and rasgrp1

DIOPT Version :9

Sequence 1:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001093748.2	Gene:	rasgrp1 / 100101791	XenbaseID:	XB-GENE-489811	Length:	811	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	94/377 - (24%)
Similarity:	152/377 - (40%)	Gaps:	64/377 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 FPHVPVRHFAEQLTRMDTELFKRL--------IPHQCLGHTWARRDSGGSETVVATINQFNAVLF 508
            |.|:..:..||.||.::.:.|:|:        |...|:      :::...|..:|..|..:
Frog   217 FDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCV------KENPTMERSIALCNGIS---- 271

  Fly   509 RVVSSILIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKER 573
            :.|..:::.|..||.||..::::|.:||:|..|:||::|.|:|..|..:||.||......:..:.
Frog   272 QWVQLMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDV 336

  Fly   574 MEVFTELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGT 638
            .:|..|:..:.|...|....|.|.                            .:.::..||.||.
Frog   337 NKVLNEMTELLSSCRNYDNYRRVY----------------------------NECTNFKIPILGV 373

  Fly   639 FLTDLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWFNSMPVF 703
            .|.||..:|.|.||:|.::| ||..|....:..:.::..||..|.......|.:.....:....:
Frog   374 HLKDLIALHEAMPDFLEDSK-INVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYY 437

  Fly   704 DEREAFELSCRLEP-----PPPAPRKSVVSTNTSLTNTTASSTASIMGH--RKTDSIHSN---SS 758
            .|.|.:|||...||     ||..|.|..|..:.:...:......:|..|  |..||:..|   ..
Frog   438 TEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQ 502

  Fly   759 SGAGSQFYCE-LNSSTSSRHNSLDRD----VHHQH--ASLMSASSSVSNLSL 803
            .|..||...| :.:|.......:|:|    :..|.  |..|.|||..|.|.|
Frog   503 DGYISQEEFEKIAASFPFSFCVMDKDREGLISRQEITAYFMRASSICSKLGL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgl	NP_001261814.1	REM	246..378	CDD:100121
		RasGEF	454..719	CDD:214539	66/277 (24%)
		RalGDS_RA	858..946	CDD:176351
rasgrp1	NP_001093748.2	REM	77..193	CDD:100121
		RasGEF	217..453	CDD:214539	67/274 (24%)
		EF-hand_7	494..543	CDD:372618	10/48 (21%)
		C1_1	558..607	CDD:365894
		BRLZ	744..799	CDD:197664
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910