DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and MAP3K13

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001229243.1	Gene:	MAP3K13 / 9175	HGNCID:	6852	Length:	966	Species:	Homo sapiens

Alignment Length:	1067	Identity:	278/1067 - (26%)
Similarity:	412/1067 - (38%)	Gaps:	306/1067 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EEQQLQQQQQQQQLEQLHHP-------QIPE----------IPIPDLEQVETQVGDGSLWTALYD 53
            |:||.:...:.:.:|.:|.|       .:.|          :.:.:.::.||.|..|:..|.
Human    44 EDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTV--- 105

  Fly    54 YDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIG---DKVGVFPKDFVTDEDPLQLNVSSA 115
                 :.|.|....:|.:..|...  ||..|:..|..|   ....:..|.:.||....|.:.
Human   106 -----DGESTSGTEDIKIQFSRSG--SGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDT--- 160

  Fly   116 IGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLF 180
                  .|:.:.|:...:.:|||....|..|.:..||||||...:..|.|::.:|
Human   161 ------WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLR---------- 209

  Fly   181 WALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRIL-AG-KIPPDVLVNWAIQIARGMNYLHNE 242
             .|||.||.|.:|||.... .|::|||...|.|..:| || ||.|.:||:|:..||.||||||..
Human   210 -KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLH 273

  Fly   243 APMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISV 306
               .||||||||.|||:      .|..  .:||:|||.::|:.: :.:||.|||.|||.||||..
Human   274 ---KIIHRDLKSPNVLV------THTD--AVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN 327

  Fly   307 STYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQT 371
            ...|:..|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.|||:.:..|||..||:
Human   328 EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQS 392

  Fly   372 DPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEE--- 433
            .|..||.|::.|..|: ||.:....||||::...|..||:|:          :|.|:.|:.|
Human   393 KPRNRPSFRQTLMHLD-IASADVLATPQETYFKSQAEWREEV----------KKHFEKIKSEGTC 446

  Fly   434 LRNKEEQLLRVQNEQREKANLLKIREQ--------------------NLRERERVLIERELVMLQ 478
            :...:|:|:|.:.|:...|  |.|||.                    .|..||:.||:||..:.:
Human   447 IHRLDEELIRRRREELRHA--LDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEK 509

  Fly   479 PVPS--------------------KRK---HKKGKKNKPLQI----SLPTGFRHTITAVRDKAEQ 516
            ..|.                    |||   ||.|.:.|...:    .:||      |.|...|..
Human   510 KYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPT------TEVAPTASP 568

  Fly   517 -PGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERS---------LLPSQLSGGQPEWPAQ-TSTH 570
             .|||..|       |...|.: :.....|:|..|         :|.:|        ||| .|.|
Human   569 LSGSPKMS-------TSSSKSR-YRSKPRHRRGNSRGSHSDFAAILKNQ--------PAQENSPH 617

  Fly   571 SSFSKSA----PNL--DKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTR 629
            .::...|    |:|  ....|||.||      |||.:              :...:|.:.:
Human   618 PTYLHQAQSQYPSLHHHNSLQQQYQQ------PPPAM--------------SQSHHPRLNM---- 658

  Fly   630 PNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSN-NNNNQTNLTSQPN 693
             :..:|..|                          |||.......:.:.|. :|:.|..|.....
Human   659 -HGQDIATC--------------------------ANNLRYFGPAAALRSPLSNHAQRQLPGSSP 696

  Fly   694 TIIVLQNGRNNSNSSTTSQSPAKIYH-----------RARSQEYG-LDHPLAYQP----PPL--- 739
            .:|......:...||...:..|..:.           :.|.::|| ||.|.| :|    |.|
Human   697 DLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSA-EPVGRSPDLSKS 760

  Fly   740 -----YLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSL--- 796
                 .|....|||.......:||       .|.::.|..|       ||..||:.||...|
Human   761 PAHNPLLENAQSSEKTEENEFSGC-------RSESSLGTSH-------LGTPPALPRKTRPLQKS 811

  Fly   797 ------------DSSSHHP----------PANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKM 839
                        ||....|          .....::|:..|......|:.||.||:...|.:
Human   812 GDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDEL--- 873

  Fly   840 SMASSERVNSKSSGDLTMYNSSTPLTARD-------CDDAEEAFEGGRFQRNFSGSQFPRHCFFT 897
                ::::..:.:..|....|.||....|       ..|.|.|....:.|.:..     :.|.
Human   874 ----ADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLG-----KLCV-- 927

  Fly   898 RQEEEGEAEDEDAVAAEVDTADADADD 924
              ||.|.........::.|::|.:..|
Human   928 --EERGYENPMQFEESDCDSSDGECSD 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	11/59 (19%)
		TyrKc	129..386	CDD:197581	113/260 (43%)
		STKc_MLK	134..389	CDD:270963	114/258 (44%)
MAP3K13	NP_001229243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..114		7/31 (23%)
		STYKc	168..402	CDD:214568	112/255 (44%)
		STKc_MAP3K12_13	174..410	CDD:270961	114/258 (44%)
		Leucine-zipper 1	433..454		5/30 (17%)
		Leucine-zipper 2	486..507		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..599		21/78 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..655		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..834		25/104 (24%)
		Acidic. /evidence=ECO:0000305	815..828		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..908		13/68 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010