DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and RIPK2

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_003812.1	Gene:	RIPK2 / 8767	HGNCID:	10020	Length:	540	Species:	Homo sapiens

Alignment Length:	343	Identity:	101/343 - (29%)
Similarity:	170/343 - (49%)	Gaps:	49/343 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 VSSAIGDIQPHEIEYNELDIKEVI-GSGGFCKVHRGYYDGEEVAIKIAH-QTGEDDMQRMRDNVL 174
            :.||:..|..|::    .|::.:. |:.|.....|......:||:|..| .|...|.:  |.:||
Human     6 ICSALPTIPYHKL----ADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSE--RKDVL 64

  Fly   175 QEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRILAGKIP-PDVLVNWAI------Q 231
            :||::....:...|..:.|:|...: |.:|.||...||||.:|..|.. |||.  |.:      :
Human    65 REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVA--WPLRFRILHE 127

  Fly   232 IARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA--REMYNTQRMSA-- 292
            ||.|:|||||..| .::|.|||:.|:|:.....        :||.||||:  |.|..:|..|:
Human   128 IALGVNYLHNMTP-PLLHHDLKTQNILLDNEFH--------VKIADFGLSKWRMMSLSQSRSSKS 183

  Fly   293 ---AGTYAWMPPEVISVSTYSKFS---DVWSYGVLLWELITGETPYKGF-DPLSVAYGVA----- 345
               .||..:||||.......|:.|   |::||.|:.||:::.:.|::.. :||.:.|.|:
Human   184 APEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRP 248

  Fly   346 -VNTLTLP--IPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQE 407
             :|..:||  ||......  :|::|.|..:|.:||.|.:.|.:||.:..:...:|..|:...:::
Human   249 VINEESLPYDIPHRARMI--SLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKK 311

  Fly   408 CWRKEIAGVLHDLREKEK 425
            ...:.::..:| |.:|:|
Human   312 TKLQSVSSAIH-LCDKKK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	89/285 (31%)
		STKc_MLK	134..389	CDD:270963	90/283 (32%)
RIPK2	NP_003812.1	STKc_RIP2	20..303	CDD:270928	92/297 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369
		CARD_RIP2_CARD3	438..524	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910