DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and RIPK1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	692	Identity:	149/692 - (21%)
Similarity:	246/692 - (35%)	Gaps:	248/692 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENI 188
            :|..|||      ||||.||...::..:.:.|......|.:.::. .:.:|:|||:...|:|..:
Human    18 LESAELD------SGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEH-NEALLEEAKMMNRLRHSRV 75

  Fly   189 AALRGVCLNT-KLCLVMEYARGGSLNRILAGKI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHR 250
            ..|.||.:.. |..|||||...|:|..:|..::  |..|.....::|..||.|||.:   .:||:
Human    76 VKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGK---GVIHK 137

  Fly   251 DLKSSNVLIYEAIEGNHLQQKTLKITDFGLA----------------REMYNTQRMSAAGTYAWM 299
            |||..|:|:.....        :||.|.|||                ||:..|.:.: .||..:|
Human   138 DLKPENILVDNDFH--------IKIADLGLASFKMWSKLNNEEHNELREVDGTAKKN-GGTLYYM 193

  Fly   300 PPEVIS--VSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTL----------- 351
            .||.::  .:..::.|||:|:.|:||.:...:.||:.        .:....|.:
Human   194 APEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEN--------AICEQQLIMCIKSGNRPDVD 250

  Fly   352 PIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFH--YMQECWRKEIA 414
            .|.:.||....:|||.||:.:|..||.|..|                :|.|.  |:.:
Human   251 DITEYCPREIISLMKLCWEANPEARPTFPGI----------------EEKFRPFYLSQ------- 292

  Fly   415 GVLHDLREK-EKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQ 478
                 |.|. |:..:::::|..|:...:.|:|:.|.:                          ..
Human   293 -----LEESVEEDVKSLKKEYSNENAVVKRMQSLQLD--------------------------CV 326

  Fly   479 PVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGS-PSFSGLRIVALTDGHKGKTW-GP 541
            .|||.|.:                         ...||||| .|..||.:     |...::| .|
Human   327 AVPSSRSN-------------------------SATEQPGSLHSSQGLGM-----GPVEESWFAP 361

  Fly   542 STMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVA------------- 593
            |..|.:|.:         :|...::....:::......:|::.:||.:|.||
Human   362 SLEHPQEEN---------EPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSH 417

  Fly   594 ------------------------------SLTPPPGL----------GILGGSGGAGGTPATP- 617
                                          ::..|.||          ..|..|.|.|..|..|
Human   418 DPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPG 482

  Fly   618 -----LLYPGIPIILTR------PNNNNIGNCKAITTTITTTTTTTTNNN------NNNNNSISA 665
                 :.|..||..:..      |..|.:||    |.|:..::...|:.:      |:....|.|
Human   483 TAGPRVWYRPIPSHMPSLHNIPVPETNYLGN----TPTMPFSSLPPTDESIKYTIYNSTGIQIGA 543

  Fly   666 NNNNQLNNIST--INSNNNN--------------NQTNLTSQ 691
            .|..::...|:  ::|.|.|              |.|:||.:
Human   544 YNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDK 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	80/288 (28%)
		STKc_MLK	134..389	CDD:270963	78/286 (27%)
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	82/309 (27%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582		62/372 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458		9/68 (13%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547		4/15 (27%)
		Death_RIP1	583..668	CDD:260048	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810