DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and tnni3k

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001191752.1	Gene:	tnni3k / 799621	ZFINID:	ZDB-GENE-081104-399	Length:	835	Species:	Danio rerio

Alignment Length:	547	Identity:	138/547 - (25%)
Similarity:	220/547 - (40%)	Gaps:	135/547 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DLEQVETQVGDGSLWTALYDYDAQGEDELT----------LR--------RGEIVVVLSTDSEVS 80
            :||.|:..:|..::     ..:.||.|..|          :|        .|::.:|....|..|
Zfish   318 NLEMVKYLLGQNAM-----SINHQGRDGHTGLHSACFHGHIRLVQFLLDNGGDMNLVACDPSRSS 377

  Fly    81 GD------VGWWTGKIGDKVGVFPKDFVTDEDPLQLN-------------VSSAIGDIQP----- 121
            |:      :.|...|..|.:....|.:...:|....|             |.|.:|.|:.
Zfish   378 GEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDDSPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEK 442

  Fly   122 -------------HEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNV 173
                         ..::.:||:..|:||||.|.||::|....:.||||           |.|.|.
Zfish   443 ADVLLLRASLPSNFHLQLSELEFNEIIGSGSFGKVYKGKCRNKIVAIK-----------RYRPNT 496

  Fly   174 ----------LQEAKLFWALKHENIAALRGVCLN--TKLCLVMEYARGGSLNRILAGK-----IP 221
                      .:|..:...|.|..:....|.||:  ::..:|.:|..||||..:|..:     :.
Zfish   497 YCSKSDTDMFCREVSILCRLNHPCVIQFVGACLDDPSQFAIVTQYVSGGSLFSLLHEQKRIIDLQ 561

  Fly   222 PDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYN 286
            ..:::  ||.:|:||.|||| ....||||||.|.|:|:||  :|:.:      :.|||.:|.:.:
Zfish   562 SKLII--AIDVAKGMEYLHN-LTQPIIHRDLNSHNILLYE--DGHAV------VADFGESRFLLS 615

  Fly   287 TQR---MSAAGTYAWMPPEVISVST-YSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVN 347
            ...   ....|...||.|||.:..| |:..:|::||.:.||||:|||.|:....|.:.|..:|.:
Zfish   616 VDEDNMTKQPGNLRWMAPEVFTQCTRYTVKADMFSYALCLWELLTGEIPFAHLKPAAAAADMAYH 680

  Fly   348 TLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIAC-----------SKFTLTPQES 401
            .:..||..:.|:...||:...|...|.:||.|.|::.:||...|           |..:|:|..|
Zfish   681 HVRPPIGYSIPKPISALLMRGWNVCPEERPEFSEVVAKLEECLCNVELMSPASSNSSGSLSPSSS 745

  Fly   402 FHYMQEC-------WRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIRE 459
                .:|       .|..:|.:       ..||:.  |...|........||..|..:..|.:.|
Zfish   746 ----TDCLAARGSPGRSHVAAL-------RSRFEL--EYALNARAYAFWTQNSARRSSQGLSLDE 797

  Fly   460 QNLRERERVLIERELVMLQPVPSKRKH 486
            .. |..:...|:|...:..|:.:.|.|
Zfish   798 MR-RNMQFPPIDRNGYVSDPMSTMRFH 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	14/80 (18%)
		TyrKc	129..386	CDD:197581	88/277 (32%)
		STKc_MLK	134..389	CDD:270963	88/275 (32%)
tnni3k	NP_001191752.1	ANK	<56..121	CDD:238125
		Ank_4	67..121	CDD:290365
		ANK repeat	67..98	CDD:293786
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		Ank_2	105..195	CDD:289560
		ANK repeat	136..164	CDD:293786
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		Ank_2	171..261	CDD:289560
		ANK repeat	199..232	CDD:293786
		ANK	229..360	CDD:238125	9/46 (20%)
		ANK repeat	269..302	CDD:293786
		Ank_2	274..369	CDD:289560	10/55 (18%)
		ANK repeat	304..337	CDD:293786	4/23 (17%)
		ANK	334..>401	CDD:238125	13/66 (20%)
		ANK repeat	339..369	CDD:293786	4/29 (14%)
		Ank_2	344..>411	CDD:289560	11/66 (17%)
		TyrKc	463..719	CDD:197581	88/277 (32%)
		PKc_TNNI3K	469..722	CDD:270966	88/274 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810