DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and LRRK1

DIOPT Version :9

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_078928.3 Gene:LRRK1 / 79705 HGNCID:18608 Length:2015 Species:Homo sapiens


Alignment Length:391 Identity:109/391 - (27%)
Similarity:181/391 - (46%) Gaps:78/391 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 PKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGF-CKVHRGYYDGEEVAIK----- 156
            |:.|:|| .|.:|.:.::       ::|::| |...|:|.||. ..::|..|.|:.||:|     
Human  1220 PELFMTD-FPARLFLENS-------KLEHSE-DEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK 1275

  Fly   157 -------------IAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYAR 208
                         :.|....|.|:...: ..|||.:..||:|..|.||.|:.:: .||..:|.|.
Human  1276 KFKNFANVPADTMLRHLRATDAMKNFSE-FRQEASMLHALQHPCIVALIGISIH-PLCFALELAP 1338

  Fly   209 GGSLNRILAGK------IPPDVLVNW--AIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEG 265
            ..|||.:|:..      ||...::..  |.|||.|:.|||.:   :||..||||.|:|::.....
Human  1339 LSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK---NIIFCDLKSDNILVWSLDVK 1400

  Fly   266 NHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGET 330
            .|:   .:|::|:|::|:.::...:...||..:..||:.....|.:..|::|||::|:||::|:.
Human  1401 EHI---NIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQR 1462

  Fly   331 PYKGFDPLSVAYGVAVNTLTLPIPKTC--PE-----TWGALMKSCWQTDPHKRPGFKEILKQLE- 387
            |..|...|.:|     ..|:..|....  ||     ...|||..||.|.|.|||....::.|:: 
Human  1463 PALGHHQLQIA-----KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKD 1522

  Fly   388 --------SIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRV 444
                    .:.|.|     |.:|...|   .:|...|..|.:|:.:.:..:     |.|:.|:.|
Human  1523 PTFATFMYELCCGK-----QTAFFSSQ---GQEYTVVFWDGKEESRNYTVV-----NTEKGLMEV 1574

  Fly   445 Q 445
            |
Human  1575 Q 1575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809 2/5 (40%)
TyrKc 129..386 CDD:197581 86/290 (30%)
STKc_MLK 134..389 CDD:270963 86/297 (29%)
LRRK1NP_078928.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..56
ANK 1 86..116
ANK 95..214 CDD:238125
ANK 2 119..148
Ank_2 126..221 CDD:289560
ANK 3 152..182
ANK repeat 156..186 CDD:293786
ANK repeat 188..218 CDD:293786
ANK 4 193..222
LRR_RI <214..488 CDD:238064
LRR 1 279..300
leucine-rich repeat 281..303 CDD:275380
LRR 302..614 CDD:227223
LRR 2 303..324
leucine-rich repeat 304..330 CDD:275380
LRR 3 330..351
leucine-rich repeat 331..353 CDD:275380
LRR 4 353..374
leucine-rich repeat 354..381 CDD:275380
LRR_RI 379..641 CDD:238064
LRR 5 381..402
leucine-rich repeat 382..405 CDD:275380
LRR 6 405..426
leucine-rich repeat 406..451 CDD:275380
LRR 7 427..447
LRR 8 451..472
leucine-rich repeat 452..474 CDD:275380
LRR 9 474..495
leucine-rich repeat 475..498 CDD:275380
LRR 10 498..519
leucine-rich repeat 499..549 CDD:275380
LRR 11 549..570
leucine-rich repeat 550..572 CDD:275380
LRR 12 572..594
LRR 13 596..617
Gem1 635..>781 CDD:224025
P-loop_NTPase 639..821 CDD:304359
COR 844..1036 CDD:292713
S_TKc 1245..1511 CDD:214567 83/278 (30%)
STKc_LRRK1 1248..1523 CDD:270969 85/287 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1788..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1899
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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