DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and MAP3K12

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001180440.1	Gene:	MAP3K12 / 7786	HGNCID:	6851	Length:	892	Species:	Homo sapiens

Alignment Length:	753	Identity:	211/753 - (28%)
Similarity:	323/753 - (42%)	Gaps:	204/753 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187
            |:.:.|:...:.:|||....|..|.:.|||||:|......|.|::.:|           .|||.|
Human   152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR-----------KLKHPN 205

  Fly   188 IAALRGVCLNTK-LCLVMEYARGGSLNRIL-AGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249
            |...:|||.... .|::||:...|.|..:| ||: :.|.:||:|::.||.||||||..   .|||
Human   206 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH---KIIH 267

  Fly   250 RDLKSSNVLI-YEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISVSTYSKF 312
            |||||.|:|| |:.:         :||:|||.::|:.: :.:||.|||.|||.||||.....|:.
Human   268 RDLKSPNMLITYDDV---------VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323

  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP 377
            .|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.:||:.:..|::.||.:.|..||
Human   324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 388

  Fly   378 GFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEEL--RNKEEQ 440
            .|::||..|: ||.:....||||::...|..||:|:......::.:......:||||  |.:||.
Human   389 SFRQILLHLD-IASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREEL 452

  Fly   441 L----LRVQNEQR-EKAN-----------LLKIREQNLRERERVLIERELVMLQPVPSK------ 483
            .    :|...|:: |:||           .|:::|:.|..||:.|..|...:|:|.||:
Human   453 RHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGN 517

  Fly   484 --RKHKKGKKNKPLQIS-----------------------------LPTG-----------FRHT 506
              .|..| |:|.|.::|                             .|.|           .||.
Human   518 TMEKLIK-KRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHR 581

  Fly   507 ITAVRDKA------------EQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGG 559
            ..:.:...            .:||.|...|    .|..|.......|..:......||..::|..
Human   582 KASAKGSCGDLPGLRTAVPPHEPGGPGSPG----GLGGGPSAWEACPPALRGLHHDLLLRKMSSS 642

  Fly   560 QPEW------------------------------PAQTSTHSSFSKSAPNLDKKQQQQNQQQVAS 594
            .|:.                              |::.|...|.|..:|...|.:
Human   643 SPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGE---------- 697

  Fly   595 LTPPP-----GLGILG----GSGGAGG--------TPATPLLYPGIPIILTRPNNNNIGNCK--- 639
             .|||     |:|:||    |:.|.||        |||. |||..   .:||.....|.:.:
Human   698 -PPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAA-LLYRA---AVTRSQKRGISSEEEEG 757

  Fly   640 AITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNN-NNNQTNLTSQPNTIIVLQNGRN 703
            .:.:.:..|::.....:.|...|           :||.:|.| ::.:....|:|:     .:|..
Human   758 EVDSEVELTSSQRWPQSLNMRQS-----------LSTFSSENPSDGEEGTASEPS-----PSGTP 806

  Fly   704 NSNSSTTSQSPAKIYHRARSQE---YGLDHPLAYQPPP 738
            ...|:.|.:.|.:     ||.:   .|.:.||  .|||
Human   807 EVGSTNTDERPDE-----RSDDMCSQGSEIPL--DPPP 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	107/261 (41%)
		STKc_MLK	134..389	CDD:270963	108/259 (42%)
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	108/259 (42%)
MAP3K12	NP_001180440.1	TyrKc	165..397	CDD:197581	107/254 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010