Protein Alignment slpr and Mlkl

DIOPT Version :9

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001297542.1
• Gene: Mlkl / 74568
• MGIID: 1921818
• Length: 472
• Species: Mus musculus
• Alignment Length: 452
• Identity: 95/452 - (21%)
• Similarity: 182/452 - (40%)
• Gaps: 97/452 - (21%)

  Fly     8 QQLQQQQQQQQLEQLHHPQIPEIPIPD------------LEQVETQVGDGSLWTALYDYDAQGED 60
            |.||:.|.|.:..           :||            |::...|:...|..:.::.:.:.|.|
Mouse    40 QPLQRLQAQGKKN-----------LPDDITAALGRFDEVLKEANQQIEKFSKKSHIWKFVSVGND 93

  Fly    61 ELTLRR---------GEIVVVL-----STDSEVSGDVGWW---------TGKIGDKVGVFPKDFV 102
            ::....         .|::::|     :|.|:||....|.         .|....||.:......
Mouse    94 KILFHEVNEKLRDVWEELLLLLQVYHWNTVSDVSQPASWQQEDRQDAEEDGNENMKVILMQLQIS 158

  Fly   103 TDEDPLQLNVSSAIGDIQPHEIEYNELDIKEV-----------IGSGGFCKVHRGYYDGEEVAIK 156
            .:|    :|.:.....::|.:....:|.|||:           :.:.....::||.|....|.||
Mouse   159 VEE----INKTLKQCSLKPTQEIPQDLQIKEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVTIK 219

  Fly   157 IAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLN-----TKLCLVMEYARGGSLNRIL 216
            :.:....:.:..:|.....|.|........||..:.|:|::     .:..:||||...|:|..:|
Mouse   220 VFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELL 284

  Fly   217 AGK--IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFG 279
            ..:  :...|.....::.|||:..||:.   ..:||::.||:.|:....:        :|:..|.
Mouse   285 DREKDLTMSVRSLLVLRAARGLYRLHHS---ETLHRNISSSSFLVAGGYQ--------VKLAGFE 338

  Fly   280 LAREMYNTQRMSAAGTYAWMPPEVISVS---------TYSKFSDVWSYGVLLWELITGETPYKGF 335
            |::...:..| :|..|.|......|.||         .|...::::|:|::|||:.||:.|::|.
Mouse   339 LSKTQNSISR-TAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGC 402

  Fly   336 DPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP--------GFKEILKQLESI 389
            |...:...||.:....|:.:.|||....::..|...:|.:||        |.:.||::|.::
Mouse   403 DSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGRSLSGRERILERLSAV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	12/79 (15%)
		TyrKc	129..386	CDD:197581	69/291 (24%)
		STKc_MLK	134..389	CDD:270963	66/289 (23%)
Mlkl	NP_001297542.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000250|UniProtKB:Q8NB16	1..143		19/113 (17%)
		PHA02988	198..446	CDD:165291	62/259 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900