Protein Alignment slpr and Map3k13

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_766409.2
• Gene: Map3k13 / 71751
• MGIID: 2444243
• Length: 959
• Species: Mus musculus
• Alignment Length: 1032
• Identity: 274/1032 - (26%)
• Similarity: 411/1032 - (39%)
• Gaps: 235/1032 - (22%)

  Fly     2 LPISEEQQLQQQQQQQQLEQLHHPQIPEIP---------------IPDLEQVETQVGD---GSLW 48
            ||::|.:....:.:...:.....|::||.|               .|....|.|.|.:   |...
Mouse    16 LPLTENKTSGGRNELAAMGNHPSPKLPEDPQERGAIQSELMEITGSPISTTVLTSVSEDSRGQFE 80

  Fly    49 TALYDYDAQGEDELTLRRG--------------EIVVVLSTDSEVSGDVGWWTGKIG---DKVGV 96
            .::.....|.|.|:||..|              :|.:..|...  ||..|:..|..|   ....:
Mouse    81 NSVLQLREQDESEMTLSLGNSNTVDGENTNGPEDIKIQFSRSG--SGSGGFLEGLFGCLRPVWNI 143

  Fly    97 FPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQT 161
            ..|.:.||....|.:.         .|:.:.|:...:.:|||....|..|.:..||||||...:.
Mouse   144 IGKAYSTDYKLQQQDT---------WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQ 199

  Fly   162 GEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRIL-AG-KIPPD 223
            .|.|::.:|           .|||.||.|.:|||.... .|::|||...|.|..:| || ||.|.
Mouse   200 NETDIKHLR-----------KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPR 253

  Fly   224 VLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYN-T 287
            :||:|:..||.||||||..   .||||||||.|||:      .|..  .:||:|||.::|:.: :
Mouse   254 LLVDWSTGIASGMNYLHLH---KIIHRDLKSPNVLV------THTD--AVKISDFGTSKELSDKS 307

  Fly   288 QRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLP 352
            .:||.|||.|||.||||.....|:..|:||:||:||||:|||.|||..|..::.:||..|:|.||
Mouse   308 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 372

  Fly   353 IPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVL 417
            :|.|||:.:..|||..||:.|..||.|::.|..|: ||.:....||||::...|..||:|:
Mouse   373 VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD-IASADVLATPQETYFKSQAEWREEV---- 432

  Fly   418 HDLREKEKRFQTIEEE---LRNKEEQLLRVQNEQREKANLLKIREQ------------------- 460
                  :|.|:.|:.|   :...:|:|:|.:.|:...|  |.|||.
Mouse   433 ------KKHFEKIKSEGTCIHRLDEELIRRRREELRHA--LDIREHYERKLERANNLYMELSAIM 489

  Fly   461 -NLRERERVLIERELVMLQPVPS--------------------KRK---HKKGKKNKPLQISLPT 501
             .|..||:.|::||..:.:..|.                    |||   ||.|.:.|...:....
Mouse   490 LQLEMREKELLKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKAGVQTKRPDLLRSE 554

  Fly   502 GFRHTITAVRDKAEQPGSPSFSGL----RIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPE 562
            |...| .||...:...|||..|..    |..:.....:|.:.|   .|....::|.:|  ..|..
Mouse   555 GIPST-EAVPTASPLSGSPKMSTASSRSRYRSKPRHRRGNSRG---SHSDFAAILKTQ--PAQEN 613

  Fly   563 WPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIIL 627
            .|..|..|.:.::.|........||..||:....|......|...|....|.|..|.|.|....|
Mouse   614 SPHPTYMHHTQAQCASVHQHNPLQQQYQQIPPAQPQSRHPRLNAHGQDIATCANNLRYFGPAAAL 678

  Fly   628 TRPNNNNI-----GNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTN 687
            ..|.:|:.     |:...:   |:|.......|:..:.:.:......|.............:..:
Mouse   679 RSPLSNHAQRQMPGSSPDL---ISTAMAADWRNSELDQDQVGPWGCCQAEPYDPCFQCRPEHSGS 740

  Fly   688 L---TSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQE-----------YGLDHPLAYQPP- 737
            |   |::|       .||:...||:.:.:|  :...|:..|           .|:.|  .:.||
Mouse   741 LDVPTTEP-------VGRSPDLSSSPAHNP--LSGNAQGSERTGANGFSGCQSGISH--QFTPPM 794

  Fly   738 ------PLYLVTDDSSETDTVAS----------PTGC------FHFLKSGNSSAASG-----AVH 775
                  ||....|||||.:....          |..|      :....|.|.|.:.|     :.|
Mouse   795 LPQKTRPLQKSGDDSSEEEGEVDSEVEFPRRQRPHRCISSYQSYSTFSSENFSVSDGEEGNTSDH 859

  Fly   776 LHRFGGSLGNSP--AVGRKKHSL-----DSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYR 833
                    .|||  :..|::..|     |..|..|.|        |.:::..|:..:..:.| .|
Mouse   860 --------SNSPDESANRRQDRLAETLDDLLSQTPEA--------PIEISSHSDGLSDKECA-VR 907

  Fly   834 DVIKKMSMASSERVNSKSSGDLTMYNSSTPLTARDCDDAEEAFEGG--RFQRNFSGS 888
            .|..:||:.   ::.::..|    |.:.......|||.:|......  |..:|:|.:
Mouse   908 RVKTQMSLG---KLCAEERG----YENPVQFGDSDCDSSEGECSDATVRTSKNYSSA 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	14/73 (19%)
		STKc_MLK	134..389	CDD:270963	114/258 (44%)
Map3k13	NP_766409.2	Leucine-zipper 1	432..453		5/30 (17%)
		Leucine-zipper 2	485..506		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	533..599		18/69 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..828		21/99 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..902		16/75 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	927..959		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		7/30 (23%)
		STKc_MAP3K12_13	173..409	CDD:270961	114/258 (44%)