Protein Alignment slpr and SRC

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_047296363.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 562
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 126/480 - (26%)
• Similarity: 189/480 - (39%)
• Gaps: 157/480 - (32%)

  Fly    43 GDGSLWTALYDYDAQGEDELTLRRGE-IVVVLSTDSEVSGDVGWW------TGKIGDKVGVFPKD 100
            |..:.:.|||||:::.|.:|:.::|| :.:|.:|:    ||  ||      ||    :.|..|.:
Human   110 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTE----GD--WWLAHSLSTG----QTGYIPSN 164

  Fly   101 FVTDEDPLQ------------------LNVSSAIGDIQPHEIEYNE---------------LDIK 132
            :|...|.:|                  ||..:..|.....|.|..:               |::|
Human   165 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 229

  Fly   133 EV----IGSGGFCKVHRGYYDG--EEVAIKIAHQTG--------------------EDDMQRMRD 171
            ..    :.||||....|..::.  :.||....|..|                    :|..:..|:
Human   230 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRE 294

  Fly   172 NV----------------------------------------LQEAKLFWALKHENIAALRGVCL 196
            ::                                        ||||::...|:||.:..|..|..
Human   295 SLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 359

  Fly   197 NTKLCLVMEYARGGSLNRILAG------KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSS 255
            ...:.:|.||...|||...|.|      ::|.  ||:.|.|||.||.|:..   |:.:||||:::
Human   360 EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYVER---MNYVHRDLRAA 419

  Fly   256 NVLIYEAIEGNHLQQKTLKITDFGLAREMYN---TQRMSAAGTYAWMPPEVISVSTYSKFSDVWS 317
            |:|:.|.:        ..|:.||||||.:.:   |.|..|.....|..||......::..|||||
Human   420 NILVGENL--------VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 476

  Fly   318 YGVLLWELIT-GETPYKG------FDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHK 375
            :|:||.||.| |..||.|      .|.:...|       .:|.|..|||:...||..||:.:|.:
Human   477 FGILLTELTTKGRVPYPGMVNREVLDQVERGY-------RMPCPPECPESLHDLMCQCWRKEPEE 534

  Fly   376 RPGFKEILKQLESIACSKFTLT-PQ 399
            ||.|:.:...||..    ||.| ||
Human   535 RPTFEYLQAFLEDY----FTSTEPQ 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	20/63 (32%)
		STKc_MLK	134..389	CDD:270963	91/336 (27%)
SRC	XP_047296363.1	SH3_Src	114..169	CDD:212941	20/64 (31%)
		SH2_Src_Src	173..273	CDD:198228	17/99 (17%)
		PTKc_Src	286..562	CDD:270656	87/294 (30%)