Protein Alignment slpr and BMX

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001712.1
• Gene: BMX / 660
• HGNCID: 1079
• Length: 675
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 84/276 - (30%)
• Similarity: 133/276 - (48%)
• Gaps: 26/276 - (9%)

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGE-EVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHE 186
            |::..|:.:.:.:|||.|..|..|.:.|: :||:|:..:....:     |...|||:....|.|.
Human   411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSE-----DEFFQEAQTMMKLSHP 470

  Fly   187 NIAALRGVCLNT-KLCLVMEYARGGSLNRILA--GK-IPPDVLVNWAIQIARGMNYLHNEAPMSI 247
            .:....|||... .:.:|.||...|.|...|.  || :.|..|:.....:..||.:|.:.   ..
Human   471 KLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESH---QF 532

  Fly   248 IHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTY 309
            |||||.:.|.|:...:        .:|::|||:.|.:.:.|.:|:.||   ..|..|||.....|
Human   533 IHRDLAARNCLVDRDL--------CVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 589

  Fly   310 SKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDP 373
            |..||||::|:|:||:.: |:.||..:|...|...|:... .|..|....:|...:|.|||...|
Human   590 SSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGH-RLYRPHLASDTIYQIMYSCWHELP 653

  Fly   374 HKRPGFKEILKQLESI 389
            .|||.|:::|..:|.:
Human   654 EKRPTFQQLLSSIEPL 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		STKc_MLK	134..389	CDD:270963	82/263 (31%)
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944
		SH2_Tec_Bmx	289..394	CDD:198262
		PTKc_Btk_Bmx	412..667	CDD:173657	82/271 (30%)
		CAV1-binding	596..603		3/6 (50%)