DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and Map3k20

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_075544.1	Gene:	Map3k20 / 65964	MGIID:	2443258	Length:	802	Species:	Mus musculus

Alignment Length:	870	Identity:	229/870 - (26%)
Similarity:	364/870 - (41%)	Gaps:	184/870 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYY--DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKH 185
            :|::::|...|..|.|.|..|:|..:  ..:|||:|...:            :.:||::...|.|
Mouse    10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKEAEILSVLSH 62

  Fly   186 ENIAALRGVCLN-TKLCLVMEYARGGSL----NRILAGKIPPDVLVNWAIQIARGMNYLHNEAPM 245
            .||....||.|. ....:|.|||..|||    |...:.::..:.::.||..:|:||:|||.|||:
Mouse    63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPV 127

  Fly   246 SIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYS 310
            .:|||||||.||:|  |.:|      .|||.|||.:|...:|..||..||:.||.||||.....|
Mouse   128 KVIHRDLKSRNVVI--AADG------VLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVS 184

  Fly   311 KFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHK 375
            :..|.:||||:|||::|.|.|:||.:.|.||:.|......|.||.:||.::..|:..||:.|..|
Mouse   185 ETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKK 249

  Fly   376 RPGFKEILKQLESIACSKFTLTPQE--SFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKE 438
            ||.||:|:..|||:  |..|..|.:  ||.:.:..||.||...|..|::.|:.....|:||:.:|
Mouse   250 RPSFKQIISILESM--SNDTNLPDQCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERE 312

  Fly   439 EQLLRVQNEQREKAN-----------------------LLK--------------IREQNLRERE 466
            .:|...:.:..|::|                       |::              .:|.|:..:.
Mouse   313 RRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYFWVQQLVRKGESSVEMSGYASLFKENNITGKR 377

  Fly   467 RVLIERELVMLQPVPSKRK--HKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIV- 528
            .:|:|.|.:....:.||..  |.|....|.....|  ...|....::|..   |.|..:..:||
Mouse   378 LLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYL--NLFHFPPLIKDSG---GEPEENEEKIVN 437

  Fly   529 -ALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHS-SFSKSAPNLDKKQQQQNQQQ 591
             .|..|...|   |.|..|..:..:..::.|.:   .|.|.... :|:.|.|:          .:
Mouse   438 LELVFGFHLK---PGTGPQDCKWKMYMEMDGDE---VAITYIKDVTFNTSLPD----------AE 486

  Fly   592 VASLTPPPGL---GILGGSGGA--------GGTPATPLLYPGIPII---LTRPNNNNIGNCKAIT 642
            :..:|.||.:   .|:|.:...        .....||.|...:..|   .|:|.:    ..||:.
Mouse   487 ILKMTKPPFVMEKWIVGIAEDQTVECTVTYENDVRTPKLTKHVHSIQWDRTKPQD----EVKAVQ 547

  Fly   643 TTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNL-TSQPNTII------VLQN 700
            ..|.|..:::..|..:.::| ||:    ...:.|:......:.|:| .||.|.|:      ...|
Mouse   548 LAIQTLFSSSEGNPGSRSDS-SAD----CQWLDTLRMRQIASHTSLQRSQSNPILGSPFFPYFAN 607

  Fly   701 GRNNSNSSTTSQSPAKIYHR-------ARSQ---EYGLDHPLAYQPPPLYLVTDDSSETDTVASP 755
            ..:.:.:...:|:|.| |.:       :||.   :|||....:    .|.|.:.||.
Mouse   608 QDSYAAAVRRTQTPVK-YQQITPSINPSRSSSPTQYGLSRNFS----SLNLSSRDSG-------- 659

  Fly   756 TGCFHFLKSGNSSAASGAV------HLHRFGGSLGNSPA---VGRKKHSLDSSSHHP------PA 805
                 |....:||:..|..      ..:|...||.:||.   .|:.:||..|...:.      |.
Mouse   660 -----FSSLNDSSSERGRYSDRSRNKYYRGSVSLNSSPKGRYGGKSQHSTPSRERYSGKFYRLPQ 719

  Fly   806 NGSNSFALPNQLTLPSEDNNTYDHAFYRDV-----IKKMSMASSERVNSKSSGDLTM--YNSST- 862
            :..|:...|:....|    |.:|....|.:     ..:.:..:.|..:..|.|..|.  |...|
Mouse   720 SALNTHQSPDFKRSP----NDHDRRVPRTIPGMPLHPETASKAGEEESRVSEGGWTKVEYRKKTH 780

  Fly   863 -PLTARDCDDAEEAFEGG-RFQRNF 885
             .|:|:   .::|...|. |.:|||
Mouse   781 RQLSAK---TSKERTRGNYRGRRNF 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	102/263 (39%)
		STKc_MLK	134..389	CDD:270963	102/261 (39%)
Map3k20	NP_075544.1	STKc_MLTK	22..263	CDD:270962	102/260 (39%)
		Leucine-zipper	287..308		5/20 (25%)
		SAM_MLTK	338..408	CDD:188928	11/69 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..802		42/201 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710