DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and abl2

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005166946.1	Gene:	abl2 / 570636	ZFINID:	ZDB-GENE-020809-2	Length:	1182	Species:	Danio rerio

Alignment Length:	1015	Identity:	213/1015 - (20%)
Similarity:	354/1015 - (34%)	Gaps:	359/1015 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWT---GKIGDKVGVFPKDFVT-- 103
            |.:|:.||||:.|.|::.|::.:||.:.||..:..     |.|:   .|.|.  |..|.:::|
Zfish   113 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN-----GEWSEVRSKNGQ--GWVPSNYITPV 170

  Fly   104 -----------------------------------DEDPLQLNVS-------------------- 113
                                               :..|.||::|
Zfish   171 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTASDGKV 235

  Fly   114 --------SAIGDIQPH----------------------------------EIEYNELDIKEVIG 136
                    |.:.::..|                                  |:|..::.:|..:|
Zfish   236 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLG 300

  Fly   137 SGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVC-LNTKL 200
            .|.:.:|:.|.:  ::..:.:|.:|.::|...: :..|:||.:...:||.|:..|.||| |....
Zfish   301 GGQYGEVYVGVW--KKYNLTVAVKTLKEDTMEV-EEFLKEASVMKEVKHPNLVQLLGVCTLEPPF 362

  Fly   201 CLVMEYARGGSLNRIL----AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE 261
            .:|.||...|:|...|    ..::...||:..|.||:..|.||..:   :.|||||.:.|.|:.|
Zfish   363 YIVTEYMPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE 424

  Fly   262 AIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLW 323
                ||:    :|:.||||:|.|......:.||.   ..|..||.::.:|:|..||||::|||||
Zfish   425 ----NHV----VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLW 481

  Fly   324 ELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 387
            |:.| |.:||.|.| ||..|.:......:..|:.||.....||::|||..|..||.|.||.:..|
Zfish   482 EIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPLDRPSFAEIHQAFE 545

  Fly   388 SIACSKFTLTPQESFHYMQECWRKEIA------------GVLHD-------LREKEKRFQTIEEE 433
            ::            ||  .....:|:|            ||.|.       |..|.:..:...|.
Zfish   546 TM------------FH--DSSISEEVAEELCKTASGGQSGVAHTFGPDMPLLPSKSRGQKKHSEN 596

  Fly   434 LRNKEE---------------------QLLRVQNEQREK--ANLLKIREQNLRERER------VL 469
            ..|.||                     ....:..:||:|  ::||:..:.....|:|      ..
Zfish   597 KENMEEAGPHGPAGLATSLFVGDGRSSSSPALPRKQRDKSPSSLLEDCQDTTFTRDRKAGFFSSF 661

  Fly   470 IERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAE--------QPGSPSFSGL- 525
            ::::.:......|..:.   ::|.|:.....:.||...|....|.|        .|..|...||
Zfish   662 MKKKSMSSSSATSSPQQ---QQNLPMPPKRSSSFREMETQPHKKYEPTAGFSGPPPPLPQTDGLS 723

  Fly   526 -------------RIVALTDGHK---------------GKTWG-----------PSTMHQRE-RS 550
                         |....|.|.|               ..:||           ..|:..|. :|
Zfish   724 FSPSHGEGNHVQSRCCGATFGQKPSSSNSGATSGQVGSSSSWGSLAGFFTPRLIKKTLGLRTGKS 788

  Fly   551 LLPSQLSGGQPEWPAQTSTHSSFSKSAPNLD-------KKQQQQNQQQVASLTPPPGLGILGGS- 607
            ....::||.:| :|...|| ||.|...|:|:       :.:.:...::.:|.|..|..|....|
Zfish   789 SGIDEVSGAKP-FPRSNST-SSMSAGLPDLERMALTLPRNRSKPPLERTSSTTSQPENGATRPSD 851

  Fly   608 ------------------------GGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTT---- 644
                                    |.|||..|     ||:.           |..::.:.|
Zfish   852 AILRKLDEGTAQIRDRPKAKLLPRGVAGGVRA-----PGVG-----------GEAESDSNTRGKD 900

  Fly   645 --------ITTTTTTTTNNNNNNNNSI----------SANN------NNQLNNISTINSNNNNNQ 685
                    .:.:.|:|..:.|.:|:.:          |:.:      ::|.|....::.:.:.::
Zfish   901 GQDDRQGWSSPSKTSTLGSVNLHNHKVPVLISPTLKHSSGDAHLVGVDSQGNRFKLLSDSGDRDR 965

  Fly   686 TNLTS------QPNTIIVLQ------------NGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPL 732
            ..|..      .|..:..||            :|....|..|..:|..::    |.....:..|
Zfish   966 PRLVKPKCAPPPPPMLRSLQHAYSADAADEVVSGNMEVNGDTIKRSGREV----RGARPSIPPP- 1025

  Fly   733 AYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASG 772
              |.||..:|...::.|.|.         |.:|.||...|
Zfish  1026 --QVPPAPVVPSSNNTTQTK---------LANGASSGGPG 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	19/96 (20%)
		TyrKc	129..386	CDD:197581	90/265 (34%)
		STKc_MLK	134..389	CDD:270963	90/263 (34%)
abl2	XP_005166946.1	SH3_Abl	116..169	CDD:212784	18/59 (31%)
		SH2_ABL	174..267	CDD:198189	6/92 (7%)
		PTKc_Abl	286..548	CDD:270645	93/288 (32%)
		Pkinase_Tyr	293..544	CDD:285015	90/265 (34%)
		FABD	1057..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900