DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and map3k21

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005156983.1	Gene:	map3k21 / 561518	ZFINID:	ZDB-GENE-090312-24	Length:	1017	Species:	Danio rerio

Alignment Length:	1052	Identity:	371/1052 - (35%)
Similarity:	504/1052 - (47%)	Gaps:	239/1052 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQL 110
            |||||::||:|.|||||:||||::|.|||.|:.:|||.|||||||..:||:||.::||.:..:..
Zfish    41 SLWTAVFDYEASGEDELSLRRGDVVEVLSKDAAISGDEGWWTGKINHRVGIFPSNYVTFQPVIYR 105

  Fly   111 NVSSAIGD-IQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVL 174
            .|.:...| ..|..|.::||.::|:||.|||.||:||.:..:|||:|.|.|..::|::...|:|.
Zfish   106 AVGARESDPSAPVRIPFSELVLQEIIGVGGFGKVYRGTWKVQEVAVKAARQDPDEDIKATADSVK 170

  Fly   175 QEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQIARGMN 237
            ||||||..|:|.||..|.|||| ...|||||||||||:|||.|.| :|||.:|||||:||||||.
Zfish   171 QEAKLFSMLQHPNIIKLEGVCLEEPNLCLVMEYARGGTLNRALTGRRIPPHILVNWAVQIARGMQ 235

  Fly   238 YLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPE 302
            |||.||.:.||||||||||:|:.|.||.:.:.:|||||||||||||.:.|.:|||||||:||.||
Zfish   236 YLHEEAVVPIIHRDLKSSNILLLEKIENDDIGRKTLKITDFGLAREWHKTTKMSAAGTYSWMAPE 300

  Fly   303 VISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKS 367
            ||..|.:||.|||||||||||||:|||.||:|.|.|:||||||||.||||||.||||.:..||:.
Zfish   301 VIKSSLFSKGSDVWSYGVLLWELLTGEIPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMEE 365

  Fly   368 CWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEE 432
            ||:.|||.||.|..||:||.:|..:.....||:|||.|||.||.||..:..:||.|||
Zfish   366 CWEQDPHIRPSFAAILEQLTAIEEAVMATMPQDSFHSMQEDWRVEIQEMFDELRTKEK------- 423

  Fly   433 ELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVML-------QPVPSKRKHKKGK 490
            |||::||:|.|...:|:....|||.|||.|.|||..::||||.:|       :|...|||.|..:
Zfish   424 ELRSREEELTRAALQQKSHEELLKRREQQLAEREINVLERELNILIFQQNKDKPNVKKRKGKFKR 488

  Fly   491 KNKPL----QISLPTGFRHTITA----VRDK--------AEQPGSPS-FSGLRIVAL-------- 530
            ....|    :||||:.|:|.||.    ..||        :..|.||: ...||.:.|
Zfish   489 SRLKLKDGNRISLPSDFQHKITVQASPTMDKRRSLNSTNSSPPSSPTLIPRLRAIQLSHRGDTSR 553

  Fly   531 ----------------------------------TDGH------------------KGKTWGPST 543
                                              |.|.                  ||:|||||:
Zfish   554 KGSMFVYHQDVDVTSECKPPSVFSKKVTLDESNRTWGRSTNYKPEEFEDVKKGFKKKGRTWGPSS 618

  Fly   544 MHQRERS-----LLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGI 603
            :..:||.     :.|  ||.|...|  .||...| .||.|.......|...:..|
Zfish   619 VQTKERGNGAERIRP--LSDGSSPW--STSLLKS-QKSVPLAALFADQGTNKDEA---------- 668

  Fly   604 LGGSGGAGGTPATPLLYPG-----IPIILTRPNNNNI---GNCKAITTTITTTTTTTTNNNNNNN 660
              ||..:.......|.:|.     :|:....|..|..   |..::.....|:|::|:|...:...
Zfish   669 --GSADSSDNKPKQLKFPNQVYIDLPLWKDEPGENQSSTGGGAESQEDPTTSTSSTSTTPQHTPT 731

  Fly   661 NSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRA---R 722
            ||:                                         ..|:|..::.:.:|..|   .
Zfish   732 NSL-----------------------------------------KRSTTRRRTDSVLYGCASILA 755

  Fly   723 SQEYGLD------HPLAYQPPPLYLVTDDSSETDTV----------ASPTGCFHFLKSGNSSAAS 771
            |..:|.|      :|...:|.|    .::..:.:.:          .||.|.    :|.....::
Zfish   756 SVAFGFDLQEICKNPANEEPEP----REEKKKKEGLFQRATRFRRSTSPPGG----RSRKDEIST 812

  Fly   772 GAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDV- 835
            ..|:|.    ::.:.......|..|.|....|      .|.|.|:..:..:.|.|.:......|
Zfish   813 APVNLL----AMSSISECNSTKCLLQSDFEGP------GFNLVNETGISPQSNGTGEGLHLTPVQ 867

  Fly   836 -----------IKKMSMASSERVNSKSSGDLTMYNSSTPLTARDCD-----DAEEAFEGGRFQRN 884
                       .||.|.|..:.||..|:..::..:|||..|.:..|     |.:.:.|.....|.
Zfish   868 ELSSGANSRLRRKKSSPAVCQNVNGSSNSPVSPADSSTTSTKKKADKEPPQDKQTSGESVSRPRP 932

  Fly   885 FS--GSQF------PRHCFFTRQEEEGEAEDED---AVAAEVDTA----DADADD---ECQVPAS 931
            .|  |...      .|:..::.....||...::   .:.|||.|.    |.|.:.   :|.||..
Zfish   933 LSLRGKSHSWSLLKSRNKSYSLGHYSGEKSVQNLDMLLPAEVKTGCSLLDMDTEGQKRDCTVPLC 997

  Fly   932 QMRQNSTTSRKS 943
            :::  ||.||.|
Zfish   998 RIQ--STPSRGS 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	36/56 (64%)
		TyrKc	129..386	CDD:197581	165/258 (64%)
		STKc_MLK	134..389	CDD:270963	165/256 (64%)
map3k21	XP_005156983.1	SH3_MLK1-3	42..99	CDD:212992	36/56 (64%)
		TyrKc	125..384	CDD:197581	165/258 (64%)
		STKc_MLK4	130..387	CDD:271048	165/256 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm26008
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910