DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and map3k10

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_689424.4	Gene:	map3k10 / 560932	ZFINID:	ZDB-GENE-050419-112	Length:	1062	Species:	Danio rerio

Alignment Length:	1092	Identity:	390/1092 - (35%)
Similarity:	501/1092 - (45%)	Gaps:	278/1092 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PDLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVF 97
            ||...........:.|||::||:|..::|||||||:::.|||.||:||||.|||||||.||||:|
Zfish    67 PDSHLPHHHESSNTYWTAVFDYEATADEELTLRRGDLLEVLSKDSKVSGDEGWWTGKIQDKVGIF 131

  Fly    98 PKDFVTDEDPL--QLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQ 160
            |.::||..|..  .|...:.:|...|.||::.||.::||||:|||.||::|.:..||||:|.|.|
Zfish   132 PCNYVTQRDSSYPALPPEALVGGDSPLEIDFLELRLEEVIGAGGFGKVYKGVWRAEEVAVKAARQ 196

  Fly   161 TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG-KIPPD 223
            ..::|:....:||.|||:|||.|:|.||.||||||| ...|||||||||||:|||.||| |:||.
Zfish   197 DPDEDISATAENVRQEARLFWMLRHRNIIALRGVCLREPNLCLVMEYARGGALNRALAGKKVPPR 261

  Fly   224 VLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQ 288
            ||||||:|||.||:||||:..:.||||||||||:||.|.:|.:.|..|||||||||||||.:.|.
Zfish   262 VLVNWAVQIATGMDYLHNQTFVPIIHRDLKSSNILILEPVERDDLSGKTLKITDFGLAREWHRTT 326

  Fly   289 RMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPI 353
            :||||||||||.||||.:|.:||.|||||:|||||||:|||.||:..|.|:||||||:|.|||||
Zfish   327 KMSAAGTYAWMAPEVIKLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPI 391

  Fly   354 PKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLH 418
            |.||||.:..|:..||..:|..||.|..|||:||.|..|.....|.||||.:||.||.||..:..
Zfish   392 PSTCPEAFAQLLGECWCPNPRGRPAFGSILKRLEDIEQSAMFQMPLESFHSLQEDWRLEIQQMFD 456

  Fly   419 DLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL-----VMLQ 478
            :||.|||       |||:.||.|.|...||||:...|:.|||.|.|||..::||||     .|.|
Zfish   457 ELRAKEK-------ELRSWEEALARAAEEQREQEEHLRRREQELAEREIDIVERELNIIIHQMYQ 514

  Fly   479 PVPSKRKHKKG-KKNKPLQ-------ISLPTGFRHTITAVR----DKAE--------QPGSPS-F 522
            ..|..:|.|.. ||::.|:       ||||:||.|.||...    ||.:        .|.||. .
Zfish   515 EKPQVKKRKGNFKKSRLLKLGRDSNCISLPSGFEHKITVQASPSVDKRKCQSSESTTPPASPGVI 579

  Fly   523 SGLRIVALT--DGH------------------KGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQT 567
            ..||...||  ||.                  ||:|||||:.|||||       .||:....: .
Zfish   580 PRLRAFRLTPSDGRKTWGRTAVCKKEEPGTKKKGRTWGPSSTHQRER-------VGGEDRLKS-L 636

  Fly   568 STHSSFSKSAPNLDKK-------------QQQQNQQQVASLTP---PPGLGILG-----GSGGAG 611
            .....:|.|||||.|.             .:.:...:....:|   .|.||..|     |||.||
Zfish   637 GEGKVWSSSAPNLGKSPKHAPMTAGFSSLNEMEEHCEFDDSSPGRLAPDLGSNGALEDVGSGSAG 701

  Fly   612 GTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNIST 676
                   |..||                                  .:.:|:...:..:.:::..
Zfish   702 -------LGSGI----------------------------------GSQDSVCRCSQRKKSDLLL 725

  Fly   677 INSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYL 741
            :...:......|.|.     :||.||...|     |....:....|.::.||
Zfish   726 LGCASLLAVVGLGSD-----ILQLGRQQMN-----QDEQDVREEQRKKKEGL------------- 767

  Fly   742 VTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPAN 806
                               |.::|            ||..|  .||.......||..:.||
Zfish   768 -------------------FQRTG------------RFRRS--TSPPSRTLSLSLSHNRHH---- 795

  Fly   807 GSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTPLTARDCDD 871
                     ...|||.|                   .|..|...|...|:..||:..|...|.||
Zfish   796 ---------DSILPSMD-------------------PSPSVTLLSLSSLSDCNSTKSLLPSDPDD 832

  Fly   872 -------------------------AEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEG--EAEDED 909
                                     ||.      |:|..:.|..|.|...|.....|  ....:.
Zfish   833 FAPTPSNAPPVVSPAPALNPLLDLRAES------FKREPNQSLTPTHVSATMALNRGHRRTPSDG 891

  Fly   910 AVAAEVDTA----DADADDECQVPASQMRQNS--TTSRKS---------SVTFQSVSFEEPDFVA 959
            |:.....|.    ...:|.....|.:.....:  |.||::         |:.|.|....:|   |
Zfish   892 AIRPRAQTVVGHRRTPSDGSMPFPPAHAPTITPYTGSRETLDIPRLPDPSMMFPSALRRKP---A 953

  Fly   960 TPRTTARSDLYTSS----ASISFATYRSASPS--------LSSSSTTASASP 999
            .|..|...|.||.:    .::.||.....:|:        |||.|.|.|:||
Zfish   954 PPIPTPEPDSYTGTLERPKTLEFAPRPRPTPARARPDPWKLSSLSQTLSSSP 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	36/56 (64%)
		TyrKc	129..386	CDD:197581	165/258 (64%)
		STKc_MLK	134..389	CDD:270963	165/256 (64%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992	36/56 (64%)
		STYKc	165..424	CDD:214568	165/258 (64%)
		STKc_MLK2	170..427	CDD:271050	165/256 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1087
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm26008
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.770