Protein Alignment slpr and map3k10

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_689424.4
• Gene: map3k10 / 560932
• ZFINID: ZDB-GENE-050419-112
• Length: 1062
• Species: Danio rerio
• Alignment Length: 1092
• Identity: 390/1092 - (35%)
• Similarity: 501/1092 - (45%)
• Gaps: 278/1092 - (25%)

  Fly    33 PDLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVF 97
            ||...........:.|||::||:|..::|||||||:::.|||.||:||||.|||||||.||||:|
Zfish    67 PDSHLPHHHESSNTYWTAVFDYEATADEELTLRRGDLLEVLSKDSKVSGDEGWWTGKIQDKVGIF 131

  Fly    98 PKDFVTDEDPL--QLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQ 160
            |.::||..|..  .|...:.:|...|.||::.||.::||||:|||.||::|.:..||||:|.|.|
Zfish   132 PCNYVTQRDSSYPALPPEALVGGDSPLEIDFLELRLEEVIGAGGFGKVYKGVWRAEEVAVKAARQ 196

  Fly   161 TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG-KIPPD 223
            ..::|:....:||.|||:|||.|:|.||.||||||| ...|||||||||||:|||.||| |:||.
Zfish   197 DPDEDISATAENVRQEARLFWMLRHRNIIALRGVCLREPNLCLVMEYARGGALNRALAGKKVPPR 261

  Fly   224 VLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQ 288
            ||||||:|||.||:||||:..:.||||||||||:||.|.:|.:.|..|||||||||||||.:.|.
Zfish   262 VLVNWAVQIATGMDYLHNQTFVPIIHRDLKSSNILILEPVERDDLSGKTLKITDFGLAREWHRTT 326

  Fly   289 RMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPI 353
            :||||||||||.||||.:|.:||.|||||:|||||||:|||.||:..|.|:||||||:|.|||||
Zfish   327 KMSAAGTYAWMAPEVIKLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPI 391

  Fly   354 PKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLH 418
            |.||||.:..|:..||..:|..||.|..|||:||.|..|.....|.||||.:||.||.||..:..
Zfish   392 PSTCPEAFAQLLGECWCPNPRGRPAFGSILKRLEDIEQSAMFQMPLESFHSLQEDWRLEIQQMFD 456

  Fly   419 DLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL-----VMLQ 478
            :||.|||       |||:.||.|.|...||||:...|:.|||.|.|||..::||||     .|.|
Zfish   457 ELRAKEK-------ELRSWEEALARAAEEQREQEEHLRRREQELAEREIDIVERELNIIIHQMYQ 514

  Fly   479 PVPSKRKHKKG-KKNKPLQ-------ISLPTGFRHTITAVR----DKAE--------QPGSPS-F 522
            ..|..:|.|.. ||::.|:       ||||:||.|.||...    ||.:        .|.||. .
Zfish   515 EKPQVKKRKGNFKKSRLLKLGRDSNCISLPSGFEHKITVQASPSVDKRKCQSSESTTPPASPGVI 579

  Fly   523 SGLRIVALT--DGH------------------KGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQT 567
            ..||...||  ||.                  ||:|||||:.|||||       .||:....: .
Zfish   580 PRLRAFRLTPSDGRKTWGRTAVCKKEEPGTKKKGRTWGPSSTHQRER-------VGGEDRLKS-L 636

  Fly   568 STHSSFSKSAPNLDKK-------------QQQQNQQQVASLTP---PPGLGILG-----GSGGAG 611
            .....:|.|||||.|.             .:.:...:....:|   .|.||..|     |||.||
Zfish   637 GEGKVWSSSAPNLGKSPKHAPMTAGFSSLNEMEEHCEFDDSSPGRLAPDLGSNGALEDVGSGSAG 701

  Fly   612 GTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNIST 676
                   |..||                                  .:.:|:...:..:.:::..
Zfish   702 -------LGSGI----------------------------------GSQDSVCRCSQRKKSDLLL 725

  Fly   677 INSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYL 741
            :...:......|.|.     :||.||...|     |....:....|.::.||
Zfish   726 LGCASLLAVVGLGSD-----ILQLGRQQMN-----QDEQDVREEQRKKKEGL------------- 767

  Fly   742 VTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPAN 806
                               |.::|            ||..|  .||.......||..:.||
Zfish   768 -------------------FQRTG------------RFRRS--TSPPSRTLSLSLSHNRHH---- 795

  Fly   807 GSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTPLTARDCDD 871
                     ...|||.|                   .|..|...|...|:..||:..|...|.||
Zfish   796 ---------DSILPSMD-------------------PSPSVTLLSLSSLSDCNSTKSLLPSDPDD 832

  Fly   872 -------------------------AEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEG--EAEDED 909
                                     ||.      |:|..:.|..|.|...|.....|  ....:.
Zfish   833 FAPTPSNAPPVVSPAPALNPLLDLRAES------FKREPNQSLTPTHVSATMALNRGHRRTPSDG 891

  Fly   910 AVAAEVDTA----DADADDECQVPASQMRQNS--TTSRKS---------SVTFQSVSFEEPDFVA 959
            |:.....|.    ...:|.....|.:.....:  |.||::         |:.|.|....:|   |
Zfish   892 AIRPRAQTVVGHRRTPSDGSMPFPPAHAPTITPYTGSRETLDIPRLPDPSMMFPSALRRKP---A 953

  Fly   960 TPRTTARSDLYTSS----ASISFATYRSASPS--------LSSSSTTASASP 999
            .|..|...|.||.:    .::.||.....:|:        |||.|.|.|:||
Zfish   954 PPIPTPEPDSYTGTLERPKTLEFAPRPRPTPARARPDPWKLSSLSQTLSSSP 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	36/56 (64%)
		STKc_MLK	134..389	CDD:270963	165/256 (64%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992	36/56 (64%)
		STKc_MLK2	170..427	CDD:271050	165/256 (64%)