Protein Alignment slpr and map3k9

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_689128.2
• Gene: map3k9 / 560639
• ZFINID: ZDB-GENE-081113-5
• Length: 1009
• Species: Danio rerio
• Alignment Length: 1093
• Identity: 364/1093 - (33%)
• Similarity: 483/1093 - (44%)
• Gaps: 322/1093 - (29%)

  Fly    40 TQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTD 104
            |..|.| .|||::||:|..||||:||:|:.|.|||.||.||||.|||||.|.|:||:||.::|:.
Zfish    41 TPSGAG-YWTAVFDYEATAEDELSLRKGDRVEVLSKDSLVSGDEGWWTGMIEDRVGIFPSNYVSS 104

  Fly   105 EDPLQLNVSSAIGD---------IQP-H--EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKI 157
            .     .:|..|.|         :.| |  :|:::||.::|:||.|||.||:|..::|:|||:|.
Zfish   105 N-----GISEKIRDTPEDYCDYSVPPLHLLQIDFSELALEEMIGVGGFGKVYRAIWNGQEVAVKA 164

  Fly   158 AHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAGK-I 220
            |.:..::|:.:..::|.||||||..|.|.||.||.|||| ...|||||||||||.|||.|||| |
Zfish   165 ARRDPDEDVSQTLESVRQEAKLFAMLTHPNIMALLGVCLQEPNLCLVMEYARGGPLNRALAGKRI 229

  Fly   221 PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMY 285
            ||..||:||:||||.|.|||.:|.:.:|||||||||:||.|.:|.:.|..||||:||||||||.:
Zfish   230 PPHTLVDWAVQIARAMLYLHCQAIVPVIHRDLKSSNILILERVENDDLSNKTLKVTDFGLAREWH 294

  Fly   286 NTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLT 350
            .|.:||||||||||.||||..||:||.|||||||||||||:|||.|::|.|.|:||||||:|.|:
Zfish   295 RTTKMSAAGTYAWMAPEVIRSSTFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLS 359

  Fly   351 LPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAG 415
            ||||.||||.:..||:.||..|||.||.|..||.||.:|..|.|...|.|||..:|:.|:.|:..
Zfish   360 LPIPSTCPEPFARLMEDCWNVDPHSRPPFTSILDQLTAIEESGFFEMPAESFQSLQDDWKLEVQE 424

  Fly   416 VLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVML--- 477
            :...||.|||       |||:.||:|.|...:|:.:...|:.|||.|.|||..::||||.::
Zfish   425 MFDQLRAKEK-------ELRSWEEELSRAALQQKYQEEALRRREQELAEREIHILERELNVIIHQ 482

  Fly   478 --QPVPSKRKHKKGKKNKPL-------QISLPTGFRHTITA------------VRDKAEQPGSPS 521
              |..| :.:|:.||..:..       :||||:.|:|.||.            :...:..|.||.
Zfish   483 LYQEKP-RVQHRHGKFRRSRLKLRDGNRISLPSDFQHKITVQASPSLDRRRSLLGSNSTPPNSPP 546

  Fly   522 -FSGLRIVALTDGHKGKTWGPSTMHQ--RERSLLPSQLSGGQPEWPAQTSTHS------SFSKSA 577
             ...||.:.||.|..|:.||.:...|  .|......:....|.|..|..|..:      ..|.||
Zfish   547 VLPRLRAIQLTPGVGGQAWGRNAAFQFDEEEDRKTRKKGRTQREHSADESLRTPKEGSRQRSCSA 611

  Fly   578 PNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAIT 642
            |||.:..:.                          :||.|                  |.|
Zfish   612 PNLRRSPRH--------------------------SPAVP------------------GVC---- 628

  Fly   643 TTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNS 707
                               |::...|...                                 ...
Zfish   629 -------------------SLAETENEDC---------------------------------CFP 641

  Fly   708 STTSQSPAKIY-----HR--ARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGC----FHF 761
            |.::.||.:.|     ||  :.|..||::.....       ...|.|.:.|..||:|.    ...
Zfish   642 SESADSPGQSYLCIPFHRDGSASDSYGVESGTTG-------TASDVSPSYTRRSPSGNRRSELVL 699

  Fly   762 LKSGNSSAASGAVH-------------------LHRFGG-SLGNSPAVGRKKHSLDSSSHHPPAN 806
            |..|...||.|..|                   .||.|| |.|.||.. ||....:|....||
Zfish   700 LGCGAVLAAVGLGHNLLDLMRVEECVRPRWEGLFHRTGGQSRGASPPT-RKLFKRESPRRPPP-- 761

  Fly   807 GSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNS------KSSGDLTMYNSSTPLT 865
                  ||..|||                   :|::|....||      ..|.:|.:....||
Zfish   762 ------LPTSLTL-------------------LSLSSVSDCNSTRSLLRSDSEELLVLRPPTP-- 799

  Fly   866 ARDCDDAEEAFEGGR---------------FQRNFSGSQFPRH--------CFFTRQEEEGEAED 907
                    .|...|:               |:|:...|..|.|        |...|...:|..:
Zfish   800 --------PALPPGQTPPPLNPLVNTHLESFKRHPRQSLTPTHVPSAPSAACRLHRTPSDGAIK- 855

  Fly   908 EDAVAAEVDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEP----------------- 955
                            .:|....:......||..|::||..::| |:|
Zfish   856 ----------------MKCSPAHNNHNPTPTTPSKNTVTQWTLS-EDPSEVPRLPDPNLIFPPTP 903

  Fly   956 ------------DFVATPRTTARSDLYTSSASISFATYRSASPSLSSSSTTAS 996
                        ||:|.||...|:         ...:....||:.:||:.|.|
Zfish   904 RRRFQPERPKTLDFLARPRPCPRA---------RCGSQWGESPAHTSSTETPS 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	35/56 (63%)
		STKc_MLK	134..389	CDD:270963	161/256 (63%)
map3k9	XP_689128.2	SH3_MLK1-3	47..104	CDD:212992	35/56 (63%)
		STKc_MLK1	129..398	CDD:271047	165/268 (62%)