DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and PBK

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001265874.1	Gene:	PBK / 55872	HGNCID:	18282	Length:	333	Species:	Homo sapiens

Alignment Length:	261	Identity:	71/261 - (27%)
Similarity:	114/261 - (43%)	Gaps:	56/261 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 VLQEAKLFWALKHENIAALRGV--CLNTKLCLVMEYARGGSLNRILAGK-------IPPDVLVNW 228
            ::.|||:..:|.|.||...|..  ..:..|||.|||....|||.::..:       .|..:::..
Human    82 LMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKV 146

  Fly   229 AIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSA- 292
            |:.:|||:.|||.|  ..::|.|:|||||:|....|       |:||.|.|::..:  .:.|:|
Human   147 ALNMARGLKYLHQE--KKLLHGDIKSSNVVIKGDFE-------TIKICDVGVSLPL--DENMTAP 200

  Fly   293 -----------------AGTYAWMPPEVISVS-TYSKFSDVWSYGVLLWELITGETPY------- 332
                             .||..|.|.|.:..: ..:..:|::::|:.|||::|...|:
Human   201 AFITILLVSVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDD 265

  Fly   333 ----KGFDPLSV---AYGVAVNTLTLPIPKTCPETWG---ALMKSCWQTDPHKRPGFKEILKQLE 387
                |.||....   ||..|:.|......:...|::.   .|...|...||..||....|::.||
Human   266 DDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 330

  Fly   388 S 388
            :
Human   331 T 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	69/257 (27%)
		STKc_MLK	134..389	CDD:270963	71/261 (27%)
PBK	NP_001265874.1	PKc_TOPK	32..332	CDD:270903	71/261 (27%)
PBK	NP_001265874.1	Pkinase	34..327	CDD:278497	69/255 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810