Protein Alignment slpr and MAP3K20

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Alignment Length: 863
• Identity: 223/863 - (25%)
• Similarity: 350/863 - (40%)
• Gaps: 211/863 - (24%)

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYY--DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKH 185
            :|::::|...|..|.|.|..|:|..:  ..:|||:|...:            :.:||::...|.|
Human    10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKEAEILSVLSH 62

  Fly   186 ENIAALRGVCLN-TKLCLVMEYARGGSL----NRILAGKIPPDVLVNWAIQIARGMNYLHNEAPM 245
            .||....||.|. ....:|.|||..|||    |...:.::..|.::.||..:|:||:|||.|||:
Human    63 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127

  Fly   246 SIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYS 310
            .:|||||||.||:|  |.:|      .|||.|||.:|...:|..||..||:.||.||||.....|
Human   128 KVIHRDLKSRNVVI--AADG------VLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVS 184

  Fly   311 KFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHK 375
            :..|.:||||:|||::|.|.|:||.:.|.||:.|......|.||.:||.::..|:..||:.|..|
Human   185 ETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKK 249

  Fly   376 RPGFKEILKQLESIACSKFTLTPQE--SFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKE 438
            ||.||:|:..|||:  |..|..|.:  ||.:.:..||.||...|..|::.|:.....|:||:.:|
Human   250 RPSFKQIISILESM--SNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERE 312

  Fly   439 EQLLRVQNEQREKAN-----------------------LLK--------------IREQNLRERE 466
            .:|...:.:..|::|                       |::              .:|.|:..:.
Human   313 RRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKR 377

  Fly   467 RVLIERELVMLQPVPSKRK--HKKGKKNKPLQ--ISLPTGFRHTITAVRDKAEQPGSPSFSGLRI 527
            .:|:|.|.:....:.||..  |.|....|...  |:|    .|....::|..   |.|..:..:|
Human   378 LLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINL----FHFPPLIKDSG---GEPEENEEKI 435

  Fly   528 V--ALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQ 590
            |  .|..|...|   |.|..|..:..:..::.|  .|.........:|:.:.|:          .
Human   436 VNLELVFGFHLK---PGTGPQDCKWKMYMEMDG--DEIAITYIKDVTFNTNLPD----------A 485

  Fly   591 QVASLTPPPGL---GILGGSGGAG-----------GTPATPLLYPGIPIILTRPNNNNIGNCKAI 641
            ::..:|.||.:   .|:|.:....           .||.:......|....|:|.:    ..||:
Human   486 EILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQD----EVKAV 546

  Fly   642 TTTITTTTTTTTNNNNNNNNS--------------ISANNNNQLNNISTI-------NSNNNNNQ 685
            ...|.|..|.:..|..:.::|              |::|.:.|.:..:.|       :.:..::.
Human   547 QLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSY 611

  Fly   686 TNLTSQPNTIIVLQ--NGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDD--- 745
            .....:|...|..|  ...|.|.||:.:|             |||....:    .|:|.:.|
Human   612 AAAVRRPQVPIKYQQITPVNQSRSSSPTQ-------------YGLTKNFS----SLHLNSRDSGF 659

  Fly   746 -SSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSN 809
             |..||| :|..|  .:.....:....|::       ||.:||   |.::| ..|.|..|:.|
Human   660 SSGNTDT-SSERG--RYSDRSRNKYGRGSI-------SLNSSP---RGRYS-GKSQHSTPSRG-- 708

  Fly   810 SFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVN-------SKSSGDLTMYNS--STPL- 864
                            .|...|||        .|...:|       .:|..||...|:  ..||
Human   709 ----------------RYPGKFYR--------VSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLH 749

  Fly   865 ---TARDCDDAEEAFEGG 879
               .:|..::..:..|||
Human   750 PETDSRASEEDSKVSEGG 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		STKc_MLK	134..389	CDD:270963	103/261 (39%)
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	103/260 (40%)
		Leucine-zipper	287..308		5/20 (25%)
		SAM_MLTK	338..408	CDD:188928	11/69 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800		35/156 (22%)
		Sensing domain (S). /evidence=ECO:0000269|PubMed:32289254	670..713		13/73 (18%)
		C-terminal domain (CTD). /evidence=ECO:0000269|PubMed:32289254	774..800