Protein Alignment slpr and Map3k9

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_038968663.1
• Gene: Map3k9 / 500690
• RGDID: 1562149
• Length: 1120
• Species: Rattus norvegicus
• Alignment Length: 1193
• Identity: 385/1193 - (32%)
• Similarity: 536/1193 - (44%)
• Gaps: 312/1193 - (26%)

  Fly    34 DLEQVETQVGDGS---LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVG 95
            |.|:...::|..:   .|||:::|:|.||||||||.|::|.|||.||:||||.|||||::..:||
  Rat    33 DEEEAAAELGSHATLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVG 97

  Fly    96 VFPKDFVT------------DEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYY 148
            :||.::||            .|||      |....||..||::.||.::|:||.|||.||:|.::
  Rat    98 IFPSNYVTPRSAFSSRCQPGTEDP------SCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFW 156

  Fly   149 DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSL 212
            .|:|||:|.|....::|:.:..:||.||||||..|||.||.||||||| ...||||||:||||.|
  Rat   157 VGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 221

  Fly   213 NRILAGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSN-------------------- 256
            ||:|:|| :|||:|||||:||||||||||:||.:.:|||||||||
  Rat   222 NRVLSGKRVPPDILVNWAVQIARGMNYLHDEAIVPVIHRDLKSSNSECGELGWGEQHSLSLRLCE 286

  Fly   257 VLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVL 321
            |||.:.:|...|..|||||||||||||.:.|.:||||||||||.||||..|.:||.|||||||||
  Rat   287 VLILQKVENGDLSNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVL 351

  Fly   322 LWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL 386
            ||||:|||.|::|.|.|:||||||:|.|.||||.||||.:..||:.||..|||.||.|..||.||
  Rat   352 LWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFSSILDQL 416

  Fly   387 ESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREK 451
            .:|..|.|...|::|||.:|:.|:.||..:...||.|||       |||..||:|.|...:|:.:
  Rat   417 TTIEESGFFEMPKDSFHCLQDDWKHEIQEMFDQLRAKEK-------ELRTWEEELTRAALQQKNQ 474

  Fly   452 ANLLKIREQNLRERERVLIERELVML-------QPVPSKRKHKKGKKNKPL----QISLPTGFRH 505
            ..||:.|||.|.|||..::||||.::       :|...|||.|..|....|    :||||:.|:|
  Rat   475 EELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQH 539

  Fly   506 TITA------------VRDKAEQPGSPS-FSGLRIVALTDGH----------------------- 534
            ..|.            :.:::..|.||: ...||.:.||.|.
  Rat   540 KFTVQASPTMDKRKSLISNRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRA 604

  Fly   535 ---KGKTWGPSTMHQRERSLLPSQLSG--GQPE---------WPAQT-----------STHSSFS 574
               ||:||||.|:.|:|.:      ||  |.|:         .|:::           ..:..:|
  Rat   605 PKKKGRTWGPGTLGQKELT------SGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWS 663

  Fly   575 KSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCK 639
            .|||||.|                             |..::|.| ||...::...:.::.|
  Rat   664 SSAPNLGK-----------------------------GPRSSPAL-PGFTSLMEIEDEDSEG--- 695

  Fly   640 AITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNN 704
                          ..:..|:...|.|.:............:..:...:..:|..:        |
  Rat   696 --------------PGSGENHLQHSPNQSYLCIPFPRGEDGDGPSSDGIHEEPTPV--------N 738

  Fly   705 SNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSA 769
            |.:||...:|.....|:.:.....:..|                       .||      |...|
  Rat   739 SATSTPQLTPTNSLKRSGTHHRRCEVAL-----------------------LGC------GAVLA 774

  Fly   770 ASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSNS--------FALPNQLTLPSEDNNT 826
            |:|          ||.......|...|......|||.....        .:.|.:.|.|..
  Rat   775 ATG----------LGFDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPS---- 825

  Fly   827 YDHAFYRDVIKK----------------MSMASSERVNS------KSSGDLTMYN------SSTP 863
                  |.:.||                :|::|....||      ..|.::.:|.      .:.|
  Rat   826 ------RKLFKKEEPMTLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPP 884

  Fly   864 LTARDCDD---AEEAFEGGRFQRNFSGSQFPRHCFFT--------RQEEEGEAEDEDAVAAEVDT 917
            ||  .|..   .....|  ||:|:.:.|..|.|...|        |:.....|....:|...:.:
  Rat   885 LT--QCTQNPLVNVRVE--RFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPASVPPALGS 945

  Fly   918 ADADADDECQVPASQMRQNSTTSR---------KSSVTF----------QSVSFEEP---DFVAT 960
            ....::.....|.:.|.:..:.||         ..:|.|          :..:.|.|   :|:..
  Rat   946 RSPSSNGVSPGPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPR 1010

  Fly   961 PRTTARSDLYTSSASISFATYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQD 1025
            ||.:|..........:|.:..|||||:.|||:.|.|   ::.|..|.:...::|...|.......
  Rat  1011 PRPSANRQRLDPWWFVSPSHARSASPANSSSTETPS---NLDSCFASSSSTVEERPGLPALLPLQ 1072

  Fly  1026 VQPHP----DVIKLRAQEQRQQT 1044
            ..|.|    .::.|.|:.|.|.:
  Rat  1073 AGPLPPAERTLLDLDAEGQSQDS 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	35/68 (51%)
		STKc_MLK	134..389	CDD:270963	166/276 (60%)
Map3k9	XP_038968663.1	SH3_MLK1-3	49..106	CDD:212992	34/56 (61%)
		STKc_MLK1	130..419	CDD:271047	171/288 (59%)