Protein Alignment slpr and MAP3K11

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_002410.1
• Gene: MAP3K11 / 4296
• HGNCID: 6850
• Length: 847
• Species: Homo sapiens
• Alignment Length: 907
• Identity: 335/907 - (36%)
• Similarity: 449/907 - (49%)
• Gaps: 173/907 - (19%)

  Fly    47 LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLN 111
            :||||:||:..|:|||.||:|:.|.|||.|:.:|||.|||.|::|.:||:||.::|
Human    45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYV--------- 100

  Fly   112 VSSAIGDIQPHEI-EYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQ 175
              |..|...|.|: .:.||.::||||.|||.||:||.:.||.||:|.|.|..::|:....::|.|
Human   101 --SRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ 163

  Fly   176 EAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQIARGMNY 238
            ||:||..|.|.||.||:.||| ...||||||||.||.|:|.||| ::||.||||||:||||||:|
Human   164 EARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHY 228

  Fly   239 LHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEV 303
            ||.||.:.:|||||||:|:|:.:.||.:.::.|||||||||||||.:.|.:||||||||||.|||
Human   229 LHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEV 293

  Fly   304 ISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSC 368
            |..||:||.|||||:|||||||:|||.||:|.|.|:||||||||.||||||.||||.:..||..|
Human   294 IKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADC 358

  Fly   369 WQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEE 433
            |..|||:||.|..||:|||::........|::|||.|||.|::||.|:..:||.|||       |
Human   359 WAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEK-------E 416

  Fly   434 LRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL-VMLQPVPSKRKH---KKG--KKN 492
            |.::||:|.|...|||.:|..|:.||..|.:.|..:.|||| ::||.|..:|.|   ::|  |::
Human   417 LLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRS 481

  Fly   493 K------PLQISLPTGFRHTITAVR----DKAEQ-----PG-SPSFSGLRIVALTDGHKGKTWGP 541
            |      ..:||:|..|:|.||...    |:...     || ||:|...|.:.|.....|:.||.
Human   482 KLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGR 546

  Fly   542 STMHQRERSLLPSQLSGGQPE--WPAQTSTHSSFSKSAPNLDKKQQQQNQQQ------------- 591
            .:..:.|.|      |.|:..  |        ::..|:|...:.|..:.:.:
Human   547 QSPRRLEDS------SNGERRACW--------AWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDS 597

  Fly   592 --VASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRP----NNNNIGNCKAITTTITTTTT 650
              :.|.:.||.|         .|.|..|.|.|..|   .||    ..::.|..|.|...:
Human   598 SPLGSPSTPPAL---------NGNPPRPSLEPEEP---KRPVPAERGSSSGTPKLIQRAL----- 645

  Fly   651 TTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPA 715
                                |...:.:.|............|        ||....|.||..:|.
Human   646 --------------------LRGTALLASLGLGRDLQPPGGP--------GRERGESPTTPPTPT 682

  Fly   716 KIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFL--KSGNSSAASGAVHLHR 778
            ..             |...:|||..|:.......|:..:|......|  ..|..||.|.......
Human   683 PA-------------PCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEP 734

  Fly   779 FGGSLGNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMAS 843
            .||::...|...|.......:...||. |..|...|:.|               |..|...|..|
Human   735 RGGTVSPPPGTSRSAPGTPGTPRSPPL-GLISRPRPSPL---------------RSRIDPWSFVS 783

  Fly   844 S-ERVNSKSS-------GDLTMYNSSTPLTARDCDDAEEA--FEGG----RFQRNFSGSQFP 891
            : .|.:...|       ...|::..|.|..     |:..|  |:||    |.|....|:|.|
Human   784 AGPRPSPLPSPQPAPRRAPWTLFPDSDPFW-----DSPPANPFQGGPQDCRAQTKDMGAQAP 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	31/56 (55%)
		STKc_MLK	134..389	CDD:270963	163/256 (64%)
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992	31/67 (46%)
		STKc_MLK3	113..379	CDD:271049	166/265 (63%)
		Leucine-zipper 1	403..424		11/27 (41%)
		Leucine-zipper 2	438..459		9/20 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..643		26/131 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..847		48/228 (21%)