Protein Alignment slpr and MATK

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_002369.2
• Gene: MATK / 4145
• HGNCID: 6906
• Length: 508
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 107/440 - (24%)
• Similarity: 170/440 - (38%)
• Gaps: 141/440 - (32%)

  Fly    61 ELTLRRGEIVVVLS---------TDSEVSGDVG-----------------------WWTGKIGDK 93
            ||..|:|::|.:|.         .....||..|                       |:.|||..:
Human    67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQ 131

  Fly    94 V----------GVF--------PKDFVT----DEDPLQLNVSSAIGDIQPHEIEY--NELDIKE- 133
            .          |:|        |.|:|.    ..|.:...|....|.:...|..:  |.:|:.|
Human   132 EAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEH 196

  Fly   134 --------------------------------------------VIGSGGFCKVHRGYYDGEEVA 154
                                                        .||.|.|..|.:|.|.|::||
Human   197 YSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVA 261

  Fly   155 IK-----IAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNR 214
            :|     :..|.           .|.|..:...::|||:..|.||.|:..|.:|||:...|:|..
Human   262 VKNIKCDVTAQA-----------FLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVN 315

  Fly   215 ILAGK----IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKI 275
            .|..:    :....|:.:::.:|.||.||.::   .::||||.:.|:|:.|.:        ..|:
Human   316 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESK---KLVHRDLAARNILVSEDL--------VAKV 369

  Fly   276 TDFGLA---REMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFD 336
            :|||||   |:..::.|:..    .|..||.:....::..|||||:||||||:.: |..||....
Human   370 SDFGLAKAERKGLDSSRLPV----KWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS 430

  Fly   337 PLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL 386
            ...|:..|.......| |:.||.....||.|||:.:|.:||.|:::.::|
Human   431 LKEVSEAVEKGYRMEP-PEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	18/96 (19%)
		STKc_MLK	134..389	CDD:270963	82/266 (31%)
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745	9/41 (22%)
		SH3 domain	55..106		9/38 (24%)
		SH2_csk_like	119..216	CDD:198190	16/96 (17%)
		SH2 domain	123..213		16/89 (18%)
		PTKc_Chk	229..482	CDD:270666	82/278 (29%)
		catalytic domain	236..479		81/269 (30%)