DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and Ripk2

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001178794.1	Gene:	Ripk2 / 362491	RGDID:	1309167	Length:	539	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	91/304 - (29%)
Similarity:	147/304 - (48%)	Gaps:	44/304 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 AIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAH---QTGEDDMQRMRDNVLQE 176
            ||....|| |.|::|.....:..|....|....:....|.:.:.|   .|...|.:  |:::|:|
  Rat     5 AICSALPH-IPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSE--RNDILRE 66

  Fly   177 AKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRILAGKIP-PDVLVNWAI------QIA 233
            |::....:...|..:.|:|...: |.:|.||...||||.:|..|.. |::.  |.:      :||
  Rat    67 AEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPEIA--WPLRFRILHEIA 129

  Fly   234 RGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA--REMYNTQRMS----- 291
            .|:|||||..| .::|.|||:.|:|:.....        :||.||||:  |.|..:|..|
  Rat   130 LGVNYLHNMNP-PLLHHDLKTQNILLDNEFH--------VKIADFGLSKWRMMSLSQSRSYKSAP 185

  Fly   292 AAGTYAWMPPEVISVSTYSKFS---DVWSYGVLLWELITGETPYKGF-DPLSVAYGVA----VNT 348
            ..||..:||||.......|:.|   |::||.|::||:::.:.|::.. :||.:.|.|:    .||
  Rat   186 EGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPNT 250

  Fly   349 LTLPIPKTCPETWG---ALMKSCWQTDPHKRPGFKEILKQLESI 389
            ....:|...|.. |   :|::|.|..:|.:||.|.:.|.:||.:
  Rat   251 SEENLPFDIPHR-GLMISLIQSGWAQNPDERPSFLKCLIELEPV 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	83/285 (29%)
		STKc_MLK	134..389	CDD:270963	84/283 (30%)
Ripk2	NP_001178794.1	STKc_RIP2	20..303	CDD:270928	84/288 (29%)
		STYKc	21..290	CDD:214568	82/282 (29%)
		CARD_RIP2_CARD3	437..523	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910