Protein Alignment slpr and fgfr2

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_068081038.1
• Gene: fgfr2 / 352940
• ZFINID: ZDB-GENE-030323-1
• Length: 840
• Species: Danio rerio
• Alignment Length: 541
• Identity: 130/541 - (24%)
• Similarity: 204/541 - (37%)
• Gaps: 171/541 - (31%)

  Fly    19 LEQLHHPQIPEIPIPDLEQVETQVGDGSLWTALYDYDAQ----------------GEDELT-LRR 66
            :|:..|..|.:..:|  ..|..|||..:.:......|||                |.|.|. :|.
Zfish   272 VERSPHRPILQAGLP--ANVTVQVGQDAKFVCKVYSDAQPHIQWLQHYTKNGSRYGPDGLPYVRV 334

  Fly    67 GEIVVVLSTDSEVS---------GDVGWWTGKIGDKVGV--------------------FPKDFV 102
            .:...|.:||.|:.         .|.|.:|...|:.:|:                    :|.|:|
Zfish   335 LKTAGVNTTDKEIEVLYLPNVTFEDAGEYTCLAGNSIGISYHTAWLTVHPAETNPIETDYPPDYV 399

  Fly   103 ------------------------------------------TDEDPLQLNV------------- 112
                                                      |.:.||:..|
Zfish   400 EIAIYCIGVFLIACMVVIVVVCRMRTSAKKPDFSSQPAVHKLTKQIPLRRQVTVSSDSSSSMSSS 464

  Fly   113 ----------SSAIGDIQPH---------EIEYNELDIKEVIGSGGFCKVHRGY-----YDGEEV 153
                      |||..|..|.         |...::|.:.:.:|.|.|.:|....     .|..:.
Zfish   465 TPLVRITTRRSSAHDDPIPEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKE 529

  Fly   154 AIKIAHQTGEDD-MQRMRDNVLQEAKLFWAL-KHENIAALRGVCL-NTKLCLVMEYARGGSLNRI 215
            |:.:|.:..:|| .::...:::.|.::...: :|:||..|.|.|. :..|.:::|||..|:|...
Zfish   530 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREY 594

  Fly   216 LAGKIPPDV------------------LVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEA 262
            |..:.||.:                  ||:...|:||||.||   |....|||||.:.|||:.|:
Zfish   595 LRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYL---ASQKCIHRDLAARNVLVTES 656

  Fly   263 IEGNHLQQKTLKITDFGLAREMYNTQ--RMSAAG--TYAWMPPEVISVSTYSKFSDVWSYGVLLW 323
                    ..:||.||||||:::|..  :.:..|  ...||.||.:....|:..|||||:|||:|
Zfish   657 --------NVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMW 713

  Fly   324 ELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 387
            |:.| |.:||.|. |:...:.:......:..|..|......:||.||......||.||::::.|:
Zfish   714 EIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLD 777

  Fly   388 SIACSKFTLTPQESFHYMQEC 408
            .|    .||...|  .|:..|
Zfish   778 RI----LTLATNE--EYLDLC 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	19/144 (13%)
		STKc_MLK	134..389	CDD:270963	86/285 (30%)
fgfr2	XP_068081038.1	Ig	56..148	CDD:472250
		Ig strand B	82..86	CDD:409353
		Ig strand E	114..118	CDD:409353
		Ig strand F	128..133	CDD:409353
		Ig strand G	141..144	CDD:409353
		IgI_2_FGFR	177..271	CDD:409443
		Ig strand A	177..180	CDD:409443
		Ig strand A'	188..193	CDD:409443
		Ig strand B	197..205	CDD:409443
		Ig strand C	211..216	CDD:409443
		Ig strand C'	219..221	CDD:409443
		Ig strand D	230..233	CDD:409443
		Ig strand E	237..242	CDD:409443
		Ig strand F	251..258	CDD:409443
		Ig strand G	261..271	CDD:409443
		IgI_3_FGFR2	279..383	CDD:409444	22/105 (21%)
		Ig strand A	279..282	CDD:409444	1/2 (50%)
		Ig strand A'	286..290	CDD:409444	1/5 (20%)
		Ig strand B	298..305	CDD:409444	0/6 (0%)
		Ig strand C	309..316	CDD:409444	0/6 (0%)
		Ig strand D	331..336	CDD:409444	1/4 (25%)
		Ig strand E	348..353	CDD:409444	0/4 (0%)
		Ig strand F	361..369	CDD:409444	2/7 (29%)
		Ig strand G	372..380	CDD:409444	1/7 (14%)
		PTKc_FGFR2	475..787	CDD:270679	97/329 (29%)