DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and Map3k9

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_017170611.1	Gene:	Map3k9 / 338372	MGIID:	2449952	Length:	1120	Species:	Mus musculus

Alignment Length:	1135	Identity:	380/1135 - (33%)
Similarity:	514/1135 - (45%)	Gaps:	293/1135 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DLEQVETQVGDGS---LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVG 95
            |.|:...::|..:   .|||:::|:|.||||||||.|::|.|||.||:||||.|||||::..:||
Mouse    33 DEEEAAAELGSHAALPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVG 97

  Fly    96 VFPKDFVTD------------EDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYY 148
            :||.::||.            |||      |....||..||::.||.::|:||.|||.||:|.::
Mouse    98 IFPSNYVTPRSAFSSRCQPGAEDP------SCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFW 156

  Fly   149 DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSL 212
            .|:|||:|.|....::|:.:..:||.||||||..|||.||.||||||| ...||||||:||||.|
Mouse   157 AGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 221

  Fly   213 NRILAGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKIT 276
            ||:|:|| ||||:|||||:||||||||||:||.:.||||||||||:||.:.:|...|..|.||||
Mouse   222 NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKIT 286

  Fly   277 DFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVA 341
            |||||||.:.|.:||||||||||.||||..|.:||.|||||||||||||:|||.|::|.|.|:||
Mouse   287 DFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVA 351

  Fly   342 YGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQ 406
            ||||:|.|.||||.||||.:..||:.||..|||.||.|..||.||.:|..|.|...|::|||.:|
Mouse   352 YGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFHCLQ 416

  Fly   407 ECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIE 471
            :.|:.||..:...||.|||       |||..||:|.|...:|:.:..||:.|||.|.|||..::|
Mouse   417 DDWKHEIQEMFDQLRAKEK-------ELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILE 474

  Fly   472 RELVML-------QPVPSKRKHKKGKKNKPL----QISLPTGFRHTITA------------VRDK 513
            |||.::       :|...|||.|..|....|    :||||:.|:|..|.            :.::
Mouse   475 RELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLISNR 539

  Fly   514 AEQPGSPS-FSGLRIVALTDGH--------------------------KGKTWGPSTMHQRE--- 548
            :..|.||: ...||.:.||.|.                          ||:||||.|:.|:|
Mouse   540 SSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELTS 604

  Fly   549 ----------RSLLPSQLSGGQP---EWPAQ----------TSTHSS----------FSKSAPNL 580
                      .|:....|.|...   ||..:          .:.|.|          :|.|||||
Mouse   605 GDEGVNGFGSLSMRNRSLEGEAEKHYEWSGRGHFCWFICPMLALHCSLKSLVDGYKQWSSSAPNL 669

  Fly   581 DKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTI 645
            .|                             |..::|.| ||...::...:.::.|
Mouse   670 GK-----------------------------GPRSSPAL-PGFTSLMEIEDEDSEG--------- 695

  Fly   646 TTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTT 710
                                            ..:..|:|.:..:|....|....|.:....|:.
Mouse   696 --------------------------------PGSGENHQQHSPNQSYLCIPFPRGEDGDGPSSD 728

  Fly   711 SQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVH 775
            .      .|.              :|.|:...|.....|.|.:...|..|..:...:....|||
Mouse   729 G------VHE--------------EPTPVNSATSTPQLTPTNSLKRGGTHHRRCEVALLGCGAV- 772

  Fly   776 LHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSNS--------FALPNQLTLPSEDNNTYDHAFY 832
            |...|  ||.......|...|......|||.....        .:.|.:.|.|..
Mouse   773 LAATG--LGFDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPS---------- 825

  Fly   833 RDVIKK----------------MSMASSERVNS------KSSGDLTMYN------SSTPLTARDC 869
            |.:.||                :|::|....||      ..|.::.:|.      .:.|||  .|
Mouse   826 RKLFKKEEPMTLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLT--QC 888

  Fly   870 DD---AEEAFEGGRFQRNFSGSQFPRHCFFT--------RQEEEGEAEDEDAVAAEVDTADADAD 923
            ..   .....|  ||:|:.:.|..|.|...|        |:.....|....|..|.:.:....::
Mouse   889 THNPLVNVRVE--RFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPTAAPAVLGSRSPSSN 951

  Fly   924 DECQVPASQMRQNSTTSR---------KSSVTF----------QSVSFEEP---DFVATPRTTAR 966
            .....|.:.|.:..:.||         ..:|.|          :..:.|.|   :|:..||.:|.
Mouse   952 GMSPSPGTGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSAN 1016

  Fly   967 SDLYTSSASISFATYRSASPSLSSSSTTAS 996
            .........:|.:..|||||:.|||:.|.|
Mouse  1017 RQRLDPWWFVSPSHARSASPANSSSTETPS 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	34/56 (61%)
		TyrKc	129..386	CDD:197581	166/258 (64%)
		STKc_MLK	134..389	CDD:270963	166/256 (65%)
Map3k9	XP_017170611.1	SH3_MLK1-3	49..106	CDD:212992	34/56 (61%)
Map3k9	XP_017170611.1	STKc_MLK1	130..399	CDD:271047	171/268 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1088
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm44249
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4635
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.800