DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and CG41099

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	148/738 - (20%)
Similarity:	253/738 - (34%)	Gaps:	256/738 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LYDYDAQGEDELTLRRGE-----IVVVLS----TD--SEVSGD----VGWWTGKIGDKVGVFPKD 100
            |..||.:...||:|..|:     ..::||    ||  :..:||    |.......|:|..:|..|
  Fly   394 LRTYDEKCALELSLSMGDHEFLIASILLSMGARTDRTNSKTGDSLLQVFALDRHRGEKSAIFLAD 458

  Fly   101 FVTDEDPLQLNVSSAIGDIQPHEIEYNELD--IKEVIGSGGFCKVHRGYYD-GEEVAIKIAHQTG 162
            | .|.|.:.....:|:     |....|.:.  :|::|.:|....:.  :.| |.:.|:.||
  Fly   459 F-ADLDHINFRGLTAL-----HIAALNNMPNLVKKLIVNGASSNLK--HIDCGLKSALHIA---- 511

  Fly   163 EDDMQRMRDNVLQEAKLFWALKHE------NIAALRG-----VCLNTK-LCLVMEYARGGS-LNR 214
                  :..|.:...:.|..||::      |...:.|     :||:.| ..||....|||| :|
  Fly   512 ------VEANAIDALEAFVELKNKSHDIDFNCQDINGDSPLSLCLSLKRTTLVPTLIRGGSDVN- 569

  Fly   215 ILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKS--SNVLIYEAIEGNHLQQKTLKITD 277
               ||                     |:..:|.:|:.:|:  |::.::       |.::...||.
  Fly   570 ---GK---------------------NKNNLSPLHQSIKNEDSDISLF-------LLEQGADITA 603

  Fly   278 FGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDV----WSYGVLLWELITGETPY-----K 333
            .        |:.:.:|          :.:|.....|:|    ...|:.|.....||:|.     |
  Fly   604 L--------TENLDSA----------LDLSIKHDLSEVVDALCRRGIALSINKNGESPLWSALEK 650

  Fly   334 GFDPLS---VAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFT 395
            |::.::   |.:|:..            :.|....:.|.||..|     :.|.:..||:|.
  Fly   651 GYEDVAKILVRHGIDT------------DCWDEGPEGCRQTLLH-----RAIDENKESVAI---- 694

  Fly   396 LTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIE--EELRNK-----------EEQLLRVQNE 447
                  |....:|          ||....:.....|  :|.::|           :.::|:...:
  Fly   695 ------FLIQSQC----------DLDSSRQPGPNGEGGDEAQDKASPLHLCCHWGQTKVLQTLID 743

  Fly   448 QREKANLLKIREQNLRERERVLIERE------LVMLQP-VPSKRKHKKGKKNKPLQISLPTGFRH 505
            .....||:   :...:....|.||.:      :::..| :..|.:.|.|  |.|...:|  .||:
  Fly   744 HGANVNLI---DAESKSPLHVAIESQYDEIISILLCHPDIDLKLRDKSG--NTPFATAL--DFRN 801

  Fly   506 TITAVR--DK----AEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWP 564
            ...|.|  |:    |||......:.|.:..|.|..:...:           ||..|:.
  Fly   802 HNAAQRILDRFPTAAEQMDIRGRNFLHLAILKDDLESVLF-----------LLAIQVD------- 848

  Fly   565 AQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGS--GGAGGTPATPLLYPGIPIIL 627
            ..:..|.: ::|:| |......||:....:|       ||.|:  .........||     .|.:
  Fly   849 VNSRVHDA-NQSSP-LHLAAASQNEMITRNL-------ILAGARMNERDAVQKLPL-----HIAI 899

  Fly   628 TRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLN------------NISTINSN 680
            .|      ||..|::..|         .||.:.::..|:.||.|:            .:.| .|.
  Fly   900 ER------GNLPAVSALI---------QNNADYDATDADGNNALHIAVRCAQFFIVRELLT-ESR 948

  Fly   681 NNNNQTNLTSQPNTIIVLQNGRN 703
            .|...|||           .|||
  Fly   949 VNAEATNL-----------KGRN 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	19/67 (28%)
		TyrKc	129..386	CDD:197581	54/286 (19%)
		STKc_MLK	134..389	CDD:270963	54/282 (19%)
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125
		ANK repeat	291..322	CDD:293786
		ANK repeat	325..362	CDD:293786
		Ank_2	330..431	CDD:289560	11/36 (31%)
		ANK	463..595	CDD:238125	35/180 (19%)
		ANK repeat	468..501	CDD:293786	6/39 (15%)
		Ank_2	473..572	CDD:289560	28/140 (20%)
		ANK repeat	503..539	CDD:293786	9/45 (20%)
		ANK	536..660	CDD:238125	34/173 (20%)
		ANK repeat	541..572	CDD:293786	13/55 (24%)
		ANK repeat	574..637	CDD:293786	14/87 (16%)
		Ank_2	579..670	CDD:289560	20/127 (16%)
		ANK repeat	639..670	CDD:293786	7/42 (17%)
		Ank_2	644..752	CDD:289560	23/147 (16%)
		ANK repeat	672..721	CDD:293786	14/73 (19%)
		ANK	721..843	CDD:238125	25/139 (18%)
		ANK repeat	723..752	CDD:293786	3/31 (10%)
		ANKYR	752..977	CDD:223738	57/272 (21%)
		ANK repeat	754..786	CDD:293786	5/31 (16%)
		ANK	820..944	CDD:238125	30/170 (18%)
		ANK repeat	822..855	CDD:293786	6/50 (12%)
		ANK repeat	857..888	CDD:293786	9/38 (24%)
		ANK	885..1017	CDD:238125	23/108 (21%)
		ANK repeat	890..921	CDD:293786	10/50 (20%)
		ANK repeat	923..955	CDD:293786	6/32 (19%)
		ANK repeat	996..1021	CDD:293786
		FYVE_ANFY1	1054..1116	CDD:277267
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900