Protein Alignment slpr and Map3k7

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001101390.2
• Gene: Map3k7 / 313121
• RGDID: 1309438
• Length: 606
• Species: Rattus norvegicus
• Alignment Length: 657
• Identity: 168/657 - (25%)
• Similarity: 265/657 - (40%)
• Gaps: 162/657 - (24%)

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187
            ||:|.|::::||:|.|.|..|.:..:..::||||......|      |...:.|.:....:.|.|
  Rat    30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESE------RKAFIVELRQLSRVNHPN 88

  Fly   188 IAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDV-----LVNWAIQIARGMNYLHNEAPMSI 247
            |..|.|.||| .:|||||||.||||..:|.|..|...     .::|.:|.::|:.|||:..|.::
  Rat    89 IVKLYGACLN-PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKAL 152

  Fly   248 IHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKF 312
            ||||||..|:|:   :.|.    ..|||.|||.|.:: .|...:..|:.|||.|||...|.||:.
  Rat   153 IHRDLKPPNLLL---VAGG----TVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEK 209

  Fly   313 SDVWSYGVLLWELITGETPYK--GFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHK 375
            .||:|:|::|||:||...|:.  |.....:.:.|. |....|:.|..|:...:||..||..||.:
  Rat   210 CDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH-NGTRPPLIKNLPKPIESLMTRCWSKDPSQ 273

  Fly   376 RPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELR----- 435
            ||..:||:|.:.               |.|                   :.|...:|.|:
  Rat   274 RPSMEEIVKIMT---------------HLM-------------------RYFPGADEPLQYPCQY 304

  Fly   436 NKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPS-----KRKHKKGKKNKPL 495
            :.|.|    .|......:.:.|...|...:....:|:       ||:     ||...|..||:..
  Rat   305 SDEGQ----SNSATSTGSFMDIASTNTSNKSDTNMEQ-------VPATNDTIKRLESKLLKNQAK 358

  Fly   496 QISLPTGFRHTITAVRDKAEQPGSPSFSG-----------LRIVALTDGHKGKTWGPSTMHQRER 549
            |.| .:| |.::.|.|..:.:...|:..|           .||||.|...|     |...|::..
  Rat   359 QQS-DSG-RLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATTAYTK-----PKRGHRKTA 416

  Fly   550 SL-----LPS-QLSG-GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGS 607
            |.     :|. .:|| |||.           .:|..:|.....:..  ||:|.:..|.:.::..|
  Rat   417 SFGNILDVPEIVISGNGQPR-----------RRSIQDLTVTGTEPG--QVSSRSSSPSVRMITTS 468

  Fly   608 GGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLN 672
            |.....||..|.:                         |...:|.||.::|:........::||.
  Rat   469 GPTSEKPARSLPW-------------------------TPDDSTDTNGSDNSIPMAYLTLDHQLQ 508

  Fly   673 NISTINSNNNN----------NQTNLTSQPNTIIVL-----------QNGRNNSNSSTTSQSPAK 716
            .::...::..:          .|..:..|....::|           |:.::..|:|...|...|
  Rat   509 PLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKK 573

  Fly   717 IYHRARS 723
            :....:|
  Rat   574 LLDENKS 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		STKc_MLK	134..389	CDD:270963	95/261 (36%)
Map3k7	NP_001101390.2	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		105/319 (33%)
		STKc_TAK1	42..292	CDD:270960	96/299 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..338		6/47 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..391		10/38 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..492		14/75 (19%)